Risk of hospitalization because of aseptic meningitis after measles- mumps-rubella vaccination in one- to two-year-old children

An analysis of the Vaccine Safety Datalink (VSD) project

Steven Black, Henry Shinefield, Paula Ray, Edwin Lewis, Robert Chen, John Glasser, Steven Hadler, Janet Hardy, Phil Rhodes, Emmet Swint, Robert Davis, Robert Thompson, John Mullooly, Michael Marcy, Connie Vadheim, Joel Ward, Suresh Rastogi, Robert Wise

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Objective: To assess the level of increased risk, if any, of hospitalizations for aseptic meningitis after Jeryl-Lynn mumps strain measles-mumps-rubella (MMR) vaccine in the Vaccine Safety Datalink population. Study design: A possible increased risk of aseptic meningitis 8 to 14 days after receipt of MMR was observed in a preliminary screening analysis of automated data from the Vaccine Safety Datalink (VSD) project Year 2 analysis. To further evaluate this association a retrospective 10- year matched case-control study was undertaken in the four health maintenance organizations (HMOs) in the VSD project. Cases ascertained from a broad scan of the automated data were validated against a standard case definition. Two controls matched on age, sex, HMO and HMO membership were assigned per case. Results: The VSD project involves the cooperative collection of automated vaccination and medical outcome data from four large HMOs that currently have 500 000 children younger than 7 years of age under surveillance. Review of automated screening results from the first 2 years of data revealed a possible increased risk of aseptic meningitis 0 to 14 days after MMR with a relative risk of 3.61 (95% confidence interval, 1.0 to 13.1) although the total number of cases was small. Although the automated data had suggested a possible association of aseptic meningitis with MMR containing the Jeryl- Lynn strain of mumps, review of validated hospitalized cases during the observation period did not reveal evidence of an increased risk of aseptic meningitis after MMR containing the Jeryl-Lynn strain of mumps (odds ratio <l.0 for all analyses). Conclusion: Although it is recognized that hospitalized cases represent a minority of the total cases of aseptic meningitis, it is reassuring that in this evaluation no increased risk of aseptic meningitis after MMR vaccine was found.

Original languageEnglish (US)
Pages (from-to)500-503
Number of pages4
JournalPediatric Infectious Disease Journal
Volume16
Issue number5
DOIs
StatePublished - May 1 1997

Fingerprint

Aseptic Meningitis
Mumps
Rubella
Measles
Vaccination
Hospitalization
Vaccines
Health Maintenance Organizations
Safety
Measles-Mumps-Rubella Vaccine
Case-Control Studies
Odds Ratio
Observation
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Risk of hospitalization because of aseptic meningitis after measles- mumps-rubella vaccination in one- to two-year-old children : An analysis of the Vaccine Safety Datalink (VSD) project. / Black, Steven; Shinefield, Henry; Ray, Paula; Lewis, Edwin; Chen, Robert; Glasser, John; Hadler, Steven; Hardy, Janet; Rhodes, Phil; Swint, Emmet; Davis, Robert; Thompson, Robert; Mullooly, John; Marcy, Michael; Vadheim, Connie; Ward, Joel; Rastogi, Suresh; Wise, Robert.

In: Pediatric Infectious Disease Journal, Vol. 16, No. 5, 01.05.1997, p. 500-503.

Research output: Contribution to journalArticle

Black, S, Shinefield, H, Ray, P, Lewis, E, Chen, R, Glasser, J, Hadler, S, Hardy, J, Rhodes, P, Swint, E, Davis, R, Thompson, R, Mullooly, J, Marcy, M, Vadheim, C, Ward, J, Rastogi, S & Wise, R 1997, 'Risk of hospitalization because of aseptic meningitis after measles- mumps-rubella vaccination in one- to two-year-old children: An analysis of the Vaccine Safety Datalink (VSD) project', Pediatric Infectious Disease Journal, vol. 16, no. 5, pp. 500-503. https://doi.org/10.1097/00006454-199705000-00009
Black, Steven ; Shinefield, Henry ; Ray, Paula ; Lewis, Edwin ; Chen, Robert ; Glasser, John ; Hadler, Steven ; Hardy, Janet ; Rhodes, Phil ; Swint, Emmet ; Davis, Robert ; Thompson, Robert ; Mullooly, John ; Marcy, Michael ; Vadheim, Connie ; Ward, Joel ; Rastogi, Suresh ; Wise, Robert. / Risk of hospitalization because of aseptic meningitis after measles- mumps-rubella vaccination in one- to two-year-old children : An analysis of the Vaccine Safety Datalink (VSD) project. In: Pediatric Infectious Disease Journal. 1997 ; Vol. 16, No. 5. pp. 500-503.
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AU - Lewis, Edwin

AU - Chen, Robert

AU - Glasser, John

AU - Hadler, Steven

AU - Hardy, Janet

AU - Rhodes, Phil

AU - Swint, Emmet

AU - Davis, Robert

AU - Thompson, Robert

AU - Mullooly, John

AU - Marcy, Michael

AU - Vadheim, Connie

AU - Ward, Joel

AU - Rastogi, Suresh

AU - Wise, Robert

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