RNA interference and its application in bone-related diseases

Ya Lin Li, Leigh Quarles, Hong Hao Zhou, Zhousheng Xiao

Research output: Contribution to journalShort survey

9 Citations (Scopus)

Abstract

RNA interference (RNAi) is the most exciting insight in biology in past decades, which provided new perspectives into the genome-wide surveys of gene function by targeted degradation of mRNA with the introduction of small interfering RNAs (siRNAs) or small hairpin RNAs (shRNAs) in a large variety of organisms, and turned out to be a more efficient and convenient method compared with the traditional knockout pathway. What's more, as the enhancement of its stability and improvement of its delivery vehicles, RNAi is bound to be a practical tool in determine gene function first in vitro and then in vivo. In this paper, we will focus on the recent achievements of RNAi and also depict the development of RNAi as a potentially powerful tool in studying bone-related diseases.

Original languageEnglish (US)
Pages (from-to)817-821
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume361
Issue number4
DOIs
StatePublished - Oct 5 2007

Fingerprint

Bone Diseases
RNA Interference
Bone
RNA
Genes
Small Interfering RNA
RNA Stability
Genome
Degradation
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

RNA interference and its application in bone-related diseases. / Li, Ya Lin; Quarles, Leigh; Zhou, Hong Hao; Xiao, Zhousheng.

In: Biochemical and Biophysical Research Communications, Vol. 361, No. 4, 05.10.2007, p. 817-821.

Research output: Contribution to journalShort survey

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