Rodent models of rheumatoid arthritis

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

The study of rheumatoid arthritis is greatly facilitated by animal models that enable investigation of a complex system involving inflammation, immunological tolerance, and autoimmunity. Although the models cover several species and pathogenetic mechanisms and can be classified as induced or spontaneous, all converge on arthritis. However, because each model features a different mechanism driving disease expression, the merits of each should be evaluated carefully in making the appropriate choice for the scientific question to be addressed. In addition, because the incidence and kinetics of disease vary by model, careful thought should be given to protocol design to minimize animal use.

Original languageEnglish (US)
Pages (from-to)114-122
Number of pages9
JournalComparative Medicine
Volume55
Issue number2
StatePublished - Apr 1 2005

Fingerprint

rheumatoid arthritis
Rodentia
Rheumatoid Arthritis
rodents
Autoimmunity
Arthritis
Animals
autoimmunity
Animal Models
arthritis
Inflammation
Incidence
inflammation
animal models
kinetics
Large scale systems
incidence
Kinetics
animals

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

Cite this

Rodent models of rheumatoid arthritis. / Brand, David.

In: Comparative Medicine, Vol. 55, No. 2, 01.04.2005, p. 114-122.

Research output: Contribution to journalReview article

Brand, David. / Rodent models of rheumatoid arthritis. In: Comparative Medicine. 2005 ; Vol. 55, No. 2. pp. 114-122.
@article{081333e29de9485e800ce4e85f25ab10,
title = "Rodent models of rheumatoid arthritis",
abstract = "The study of rheumatoid arthritis is greatly facilitated by animal models that enable investigation of a complex system involving inflammation, immunological tolerance, and autoimmunity. Although the models cover several species and pathogenetic mechanisms and can be classified as induced or spontaneous, all converge on arthritis. However, because each model features a different mechanism driving disease expression, the merits of each should be evaluated carefully in making the appropriate choice for the scientific question to be addressed. In addition, because the incidence and kinetics of disease vary by model, careful thought should be given to protocol design to minimize animal use.",
author = "David Brand",
year = "2005",
month = "4",
day = "1",
language = "English (US)",
volume = "55",
pages = "114--122",
journal = "Comparative Medicine",
issn = "1532-0820",
publisher = "American Association for Laboratory Animal Science",
number = "2",

}

TY - JOUR

T1 - Rodent models of rheumatoid arthritis

AU - Brand, David

PY - 2005/4/1

Y1 - 2005/4/1

N2 - The study of rheumatoid arthritis is greatly facilitated by animal models that enable investigation of a complex system involving inflammation, immunological tolerance, and autoimmunity. Although the models cover several species and pathogenetic mechanisms and can be classified as induced or spontaneous, all converge on arthritis. However, because each model features a different mechanism driving disease expression, the merits of each should be evaluated carefully in making the appropriate choice for the scientific question to be addressed. In addition, because the incidence and kinetics of disease vary by model, careful thought should be given to protocol design to minimize animal use.

AB - The study of rheumatoid arthritis is greatly facilitated by animal models that enable investigation of a complex system involving inflammation, immunological tolerance, and autoimmunity. Although the models cover several species and pathogenetic mechanisms and can be classified as induced or spontaneous, all converge on arthritis. However, because each model features a different mechanism driving disease expression, the merits of each should be evaluated carefully in making the appropriate choice for the scientific question to be addressed. In addition, because the incidence and kinetics of disease vary by model, careful thought should be given to protocol design to minimize animal use.

UR - http://www.scopus.com/inward/record.url?scp=23444454526&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23444454526&partnerID=8YFLogxK

M3 - Review article

C2 - 15884771

AN - SCOPUS:23444454526

VL - 55

SP - 114

EP - 122

JO - Comparative Medicine

JF - Comparative Medicine

SN - 1532-0820

IS - 2

ER -