Role of angiotensin-(1-7) in amino-acid-neurotransmitter-mediated blood pressure regulation in rat rostral ventrolateral medulla

Jin Wang, Lin Lin Shen, Yin Xiang Cao, Zhongjie Sun, Qiang Wang, Da Nian Zhu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The present study was undertaken to investigate the linkage between angiotensin-(1-7) [Ang-(1-7)] and the release of amino acid neurotransmitters in the the rostral ventrolateral medulla (RVLM) by techniques of microinjection, microdialysis combined with high performance liquid chromatography (HPLC)-fluorescent detection. Unilateral microinjection of Ang-(1-7) into the RVLM of anesthetized rats produced an increase in mean arterial pressure (MAP) accompanied by an increased release of glutamate (Glu). In contrast, microinjection of Ang779, a selective antagonist of Ang-(1-7) receptor, caused a decrease in MAP with a decreased release of Glu and an increased release of glycine, taurine and γ-aminobutyric acid. The presser effect of Ang-(1-7) and the depressor effect of Ang779 were in part blocked by corresponding antagonists of amino acid receptors. These results suggest that the pressor effect of Ang-(1-7) in the RVLM may be partially due to an increased release of Glu, whereas the depressor effect of Ang779 may be partially attributed to a decreased release of Glu and an increased release of inhibitory amino acid neurotransmitters.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalActa Physiologica Sinica
Volume53
Issue number1
StatePublished - Dec 1 2001

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Neurotransmitter Agents
Glutamic Acid
Blood Pressure
Microinjections
Amino Acids
Arterial Pressure
Amino Acid Receptors
Aminobutyrates
Taurine
Microdialysis
Glycine
High Pressure Liquid Chromatography
angiotensin I (1-7)

All Science Journal Classification (ASJC) codes

  • Physiology

Cite this

Role of angiotensin-(1-7) in amino-acid-neurotransmitter-mediated blood pressure regulation in rat rostral ventrolateral medulla. / Wang, Jin; Shen, Lin Lin; Cao, Yin Xiang; Sun, Zhongjie; Wang, Qiang; Zhu, Da Nian.

In: Acta Physiologica Sinica, Vol. 53, No. 1, 01.12.2001, p. 1-6.

Research output: Contribution to journalArticle

Wang, Jin ; Shen, Lin Lin ; Cao, Yin Xiang ; Sun, Zhongjie ; Wang, Qiang ; Zhu, Da Nian. / Role of angiotensin-(1-7) in amino-acid-neurotransmitter-mediated blood pressure regulation in rat rostral ventrolateral medulla. In: Acta Physiologica Sinica. 2001 ; Vol. 53, No. 1. pp. 1-6.
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