Role of potassium ion channels in detrusor smooth muscle function and dysfunction

Research output: Contribution to journalReview article

101 Citations (Scopus)

Abstract

Contraction and relaxation of the detrusor smooth muscle (DSM), which makes up the wall of the urinary bladder, facilitates the storage and voiding of urine. Several families of K + channels, including voltage-gated K + (K V) channels, Ca 2+-activated K + (K Ca) channels, inward-rectifying ATP-sensitive K + (K ir, K ATP) channels, and two-pore-domain K + (K 2P) channels, are expressed and functional in DSM. They control DSM excitability and contractility by maintaining the resting membrane potential and shaping the action potentials that determine the phasic nature of contractility in this tissue. Defects in DSM K + channel proteins or in the molecules involved in their regulatory pathways may underlie certain forms of bladder dysfunction, such as overactive bladder. K + channels represent an opportunity for novel pharmacological manipulation and therapeutic intervention in human DSM. Modulation of DSM K + channels directly or indirectly by targeting their regulatory mechanisms has the potential to control urinary bladder function. This Review summarizes our current state of knowledge of the functional role of K + channels in DSM in health and disease, with special emphasis on current advancements in the field.

Original languageEnglish (US)
Pages (from-to)30-40
Number of pages11
JournalNature Reviews Urology
Volume9
Issue number1
DOIs
StatePublished - Jan 1 2012

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Potassium Channels
Smooth Muscle
Urinary Bladder
Adenosine Triphosphate
Voltage-Gated Potassium Channels
Overactive Urinary Bladder
Membrane Potentials
Action Potentials
Urine
Pharmacology
Health

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Role of potassium ion channels in detrusor smooth muscle function and dysfunction. / Petkov, Georgi.

In: Nature Reviews Urology, Vol. 9, No. 1, 01.01.2012, p. 30-40.

Research output: Contribution to journalReview article

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