Role of single-stranded DNA regions and Y-box proteins in transcriptional regulation of viral and cellular genes

S. K. Swamynathan, Ashok Nambiar, Ramareddy Guntaka

Research output: Contribution to journalReview article

81 Citations (Scopus)

Abstract

Single-stranded regions, known to be important for optimal rates of transcription, have been observed in the promoters of several cellular genes as well as in the promoters of many pathogenic viruses. Several host-encoded, single-stranded DNA binding proteins capable of binding these regions have been purified and their genes isolated. In this review, information available about single-stranded regions present within various promoters and the interaction of a novel class of single-stranded DNA binding transcription factors belonging to the Y-box family of proteins is reviewed. Mechanisms by which these proteins influence transcription of both cellular and viral genes are proposed.

Original languageEnglish (US)
Pages (from-to)515-522
Number of pages8
JournalFASEB Journal
Volume12
Issue number7
StatePublished - 1998
Externally publishedYes

Fingerprint

single-stranded DNA
Viral Genes
Single-Stranded DNA
Genes
promoter regions
Transcription
DNA-Binding Proteins
transcription (genetics)
Protein Binding
Proteins
Transcription Factors
DNA-binding proteins
genes
proteins
protein binding
Viruses
transcription factors
viruses

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Role of single-stranded DNA regions and Y-box proteins in transcriptional regulation of viral and cellular genes. / Swamynathan, S. K.; Nambiar, Ashok; Guntaka, Ramareddy.

In: FASEB Journal, Vol. 12, No. 7, 1998, p. 515-522.

Research output: Contribution to journalReview article

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