Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease

Susan Pyne, Sue Lee, Jaclyn Long, Nigel J. Pyne

Research output: Contribution to journalReview article

93 Citations (Scopus)

Abstract

Sphingosine 1-phosphate (S1P) is a bioactive lipid that is produced by the sphingosine kinase-catalysed phosphorylation of sphingosine. S1P is an important regulator of cell function, mediating many of its effects through a family of five closely related G protein-coupled receptors (GPCR) termed S1P1-5 which exhibit high affinity for S1P. These receptors function to relay the effects of extracellular S1P via well-defined signal transduction networks linked to the regulation of cell proliferation, survival, migration etc. Diverse agonists (e.g. cytokines) also activate sphingosine kinase and the resulting S1P formed may bind to specific undefined intracellular targets to elicit cellular responses. The purpose of this review is to discuss some of the spatial/temporal aspects of intracellular S1P signalling and to define the function of sphingosine kinases and lipid phosphate phosphatases (which catalyse dephosphorylation of S1P) in terms of their regulation of cell function. Finally, we survey the function of S1P in relation to disease, where the major challenge is to dissect the role of intracellular versus extracellular actions of S1P in terms of association with defined diseased phenotypes.

Original languageEnglish (US)
Pages (from-to)14-21
Number of pages8
JournalCellular Signalling
Volume21
Issue number1
DOIs
StatePublished - Jan 1 2009
Externally publishedYes

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Health
sphingosine 1-phosphate
sphingosine kinase
lipid phosphate phosphatase
Sphingosine
G-Protein-Coupled Receptors
Signal Transduction
Cell Survival
Phosphorylation
Cell Proliferation
Cytokines
Phenotype
Lipids

All Science Journal Classification (ASJC) codes

  • Cell Biology

Cite this

Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease. / Pyne, Susan; Lee, Sue; Long, Jaclyn; Pyne, Nigel J.

In: Cellular Signalling, Vol. 21, No. 1, 01.01.2009, p. 14-21.

Research output: Contribution to journalReview article

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