Role of t cells and cytokines in effecting fibrosis

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

A number of humoral and cellular immune abnormalities are present in patients with early scleroderma (systemic sclerosis). Most of these abnormalities reflect ongoing autoimmune reactions of the cellular and humoral types, resulting in a variety of autoantibodies to cellular and tissue constituents. Evidence exists for a defect(s) in immunoregulation favoring excessive helper T cell activity. The presence of circulating cytokines and shed interleukin-2 receptors suggest ongoing cellular immune reactions are occurring, generating cytokines and lymphokines that are capable of effecting the vascular and fibrotic lesions that are hallmarks of the disease. Future directions for research are suggested that would focus on determining if, and at what point, flbroblasts might function autonomously to generate excessive matrix components and on determining the nature of the original antigenic stimulus that starts the scleroderma process.

Original languageEnglish (US)
Pages (from-to)247-258
Number of pages12
JournalInternational Reviews of Immunology
Volume12
Issue number2-4
DOIs
StatePublished - Jan 1 1995

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Fibrosis
Cytokines
Lymphokines
Systemic Scleroderma
Interleukin-2 Receptors
Helper-Inducer T-Lymphocytes
Autoantibodies
Blood Vessels
Research
Direction compound

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Role of t cells and cytokines in effecting fibrosis. / Postlethwaite, Arnold.

In: International Reviews of Immunology, Vol. 12, No. 2-4, 01.01.1995, p. 247-258.

Research output: Contribution to journalArticle

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