Role of the suprachiasmatic nuclei in the circadian timing system of the squirrel monkey. I. The generation of rhythmicity

H. Elliott Albers, Ralph Lydic, Philippa H. Gander, Martin C. Moore-Ede

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The circadian organization of squirrel monkey (Saimiri sciureus) drinking behavior was evaluated before and after the placement of radiofrequency lesions which completely destroyed the suprachiasmatic nuclei (SCN) in 4 monkeys and partially ablated the SCN in another 4 animals. In continuous illumination (LL: 600 lux) prior to surgery, each monkey had a precise free-running circadian rhythm of drinking behavior with a period of 25.13 ± 0.21 h (X ± S.E.M.). By 4-6 weeks following the lesions, the temporal organization of drinking behavior had become disrupted, but a statistically significant free-running circadian rhythm was still detectable by time series analyses. Subsequently, the circadian organization of drinking behavior in 7 out of 8 monkeys gradually decayed with either no statistically significant rhythmicity or only weak circadian and/or ultradian rhythmicity detected by time series analyses by 10-92 weeks post-lesion. The remaining animal which maintained a statistically reliable free-running rhythm in drinking behavior received the least damage (<50%) to the SCN. Despite the major alterations in the temporal patterning of behavior, the overall amount of drinking behavior per 24 h was unchanged. The SCN are thus essential for maintaining the circadian organization of squirrel monkey drinking behavior However, the existence of residual circadian rhythmicity following SCN lesions and the gradual decay of circadian organization thereafter suggest that the SCN may coordinate the activity of circadian oscillators which lie outside its borders.

Original languageEnglish (US)
Pages (from-to)275-284
Number of pages10
JournalBrain Research
Volume300
Issue number2
DOIs
StatePublished - May 23 1984
Externally publishedYes

Fingerprint

Saimiri
Drinking Behavior
Circadian Clocks
Suprachiasmatic Nucleus
Periodicity
Haplorhini
Circadian Rhythm
Lighting
Running

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Developmental Biology
  • Clinical Neurology

Cite this

Role of the suprachiasmatic nuclei in the circadian timing system of the squirrel monkey. I. The generation of rhythmicity. / Albers, H. Elliott; Lydic, Ralph; Gander, Philippa H.; Moore-Ede, Martin C.

In: Brain Research, Vol. 300, No. 2, 23.05.1984, p. 275-284.

Research output: Contribution to journalArticle

Albers, H. Elliott ; Lydic, Ralph ; Gander, Philippa H. ; Moore-Ede, Martin C. / Role of the suprachiasmatic nuclei in the circadian timing system of the squirrel monkey. I. The generation of rhythmicity. In: Brain Research. 1984 ; Vol. 300, No. 2. pp. 275-284.
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