Roma ethnicity and clinical outcomes in kidney transplant recipients

Miklos Z. Molnar, Robert M. Langer, Adam Remport, Maria E. Czira, Katalin Rajczy, Kamyar Kalantar-Zadeh, Csaba Kovesdy, Marta Novak, Istvan Mucsi, Laszlo Rosivall

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3 Citations (Scopus)

Abstract

Background Racial and ethnic disparities among North American patients with chronic kidney disease have received significant attention. In contrast, little is known about health-related outcomes of patients with end-stage renal disease among the Roma minority, also known as gypsies, compared to Caucasian individuals. We prospectively assessed the association between Roma ethnicity and long-term clinical outcomes in kidney transplant recipients. Methods In a prevalent cohort of renal transplant recipients, followed up over a median of 94 months, we prospectively collected socio-demographic, medical (and transplant related) characteristics and laboratory data at baseline from 60 Roma and 1,003 Caucasian patients (mean age 45 (SD = 11) and 49 (SD = 13) years, 33 and 41% women, 18 and 17% with diabetes mellitus, respectively). Survival analyses examined the associations between Roma ethnicity and all-cause mortality and death-censored graft loss or death with functioning renal allograft. Results: During the follow-up period, 341 patients (32%) died. Two-hundred eighty (26%) patients died with a functioning graft and 201 patients (19%) returned to dialysis. After multivariable adjustments, Roma ethnicity was associated with 77% higher risk of all-cause mortality (Hazard Ratio (HR): 1.77; 95% confidence interval (CI): 1.02, 3.07), two times higher risk of mortality with functioning graft (2.04 [1.17-3.55]) and 77% higher risk of graft loss (1.77 [1.01-3.13]), respectively. Conclusions Roma ethnicity is independently associated with increased mortality risk and worse graft outcome in kidney transplant recipients. Further studies should identify the factors contributing to worse outcomes among Roma patients.

Original languageEnglish (US)
Pages (from-to)945-954
Number of pages10
JournalInternational Urology and Nephrology
Volume44
Issue number3
DOIs
StatePublished - Jun 1 2012
Externally publishedYes

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Roma
Kidney
Transplants
Mortality
Transplant Recipients
Survival Analysis
Chronic Renal Insufficiency
Chronic Kidney Failure
Allografts
Dialysis
Cause of Death
Diabetes Mellitus
Demography
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Urology

Cite this

Molnar, M. Z., Langer, R. M., Remport, A., Czira, M. E., Rajczy, K., Kalantar-Zadeh, K., ... Rosivall, L. (2012). Roma ethnicity and clinical outcomes in kidney transplant recipients. International Urology and Nephrology, 44(3), 945-954. https://doi.org/10.1007/s11255-011-0088-6

Roma ethnicity and clinical outcomes in kidney transplant recipients. / Molnar, Miklos Z.; Langer, Robert M.; Remport, Adam; Czira, Maria E.; Rajczy, Katalin; Kalantar-Zadeh, Kamyar; Kovesdy, Csaba; Novak, Marta; Mucsi, Istvan; Rosivall, Laszlo.

In: International Urology and Nephrology, Vol. 44, No. 3, 01.06.2012, p. 945-954.

Research output: Contribution to journalArticle

Molnar, MZ, Langer, RM, Remport, A, Czira, ME, Rajczy, K, Kalantar-Zadeh, K, Kovesdy, C, Novak, M, Mucsi, I & Rosivall, L 2012, 'Roma ethnicity and clinical outcomes in kidney transplant recipients', International Urology and Nephrology, vol. 44, no. 3, pp. 945-954. https://doi.org/10.1007/s11255-011-0088-6
Molnar MZ, Langer RM, Remport A, Czira ME, Rajczy K, Kalantar-Zadeh K et al. Roma ethnicity and clinical outcomes in kidney transplant recipients. International Urology and Nephrology. 2012 Jun 1;44(3):945-954. https://doi.org/10.1007/s11255-011-0088-6
Molnar, Miklos Z. ; Langer, Robert M. ; Remport, Adam ; Czira, Maria E. ; Rajczy, Katalin ; Kalantar-Zadeh, Kamyar ; Kovesdy, Csaba ; Novak, Marta ; Mucsi, Istvan ; Rosivall, Laszlo. / Roma ethnicity and clinical outcomes in kidney transplant recipients. In: International Urology and Nephrology. 2012 ; Vol. 44, No. 3. pp. 945-954.
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abstract = "Background Racial and ethnic disparities among North American patients with chronic kidney disease have received significant attention. In contrast, little is known about health-related outcomes of patients with end-stage renal disease among the Roma minority, also known as gypsies, compared to Caucasian individuals. We prospectively assessed the association between Roma ethnicity and long-term clinical outcomes in kidney transplant recipients. Methods In a prevalent cohort of renal transplant recipients, followed up over a median of 94 months, we prospectively collected socio-demographic, medical (and transplant related) characteristics and laboratory data at baseline from 60 Roma and 1,003 Caucasian patients (mean age 45 (SD = 11) and 49 (SD = 13) years, 33 and 41{\%} women, 18 and 17{\%} with diabetes mellitus, respectively). Survival analyses examined the associations between Roma ethnicity and all-cause mortality and death-censored graft loss or death with functioning renal allograft. Results: During the follow-up period, 341 patients (32{\%}) died. Two-hundred eighty (26{\%}) patients died with a functioning graft and 201 patients (19{\%}) returned to dialysis. After multivariable adjustments, Roma ethnicity was associated with 77{\%} higher risk of all-cause mortality (Hazard Ratio (HR): 1.77; 95{\%} confidence interval (CI): 1.02, 3.07), two times higher risk of mortality with functioning graft (2.04 [1.17-3.55]) and 77{\%} higher risk of graft loss (1.77 [1.01-3.13]), respectively. Conclusions Roma ethnicity is independently associated with increased mortality risk and worse graft outcome in kidney transplant recipients. Further studies should identify the factors contributing to worse outcomes among Roma patients.",
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T1 - Roma ethnicity and clinical outcomes in kidney transplant recipients

AU - Molnar, Miklos Z.

AU - Langer, Robert M.

AU - Remport, Adam

AU - Czira, Maria E.

AU - Rajczy, Katalin

AU - Kalantar-Zadeh, Kamyar

AU - Kovesdy, Csaba

AU - Novak, Marta

AU - Mucsi, Istvan

AU - Rosivall, Laszlo

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N2 - Background Racial and ethnic disparities among North American patients with chronic kidney disease have received significant attention. In contrast, little is known about health-related outcomes of patients with end-stage renal disease among the Roma minority, also known as gypsies, compared to Caucasian individuals. We prospectively assessed the association between Roma ethnicity and long-term clinical outcomes in kidney transplant recipients. Methods In a prevalent cohort of renal transplant recipients, followed up over a median of 94 months, we prospectively collected socio-demographic, medical (and transplant related) characteristics and laboratory data at baseline from 60 Roma and 1,003 Caucasian patients (mean age 45 (SD = 11) and 49 (SD = 13) years, 33 and 41% women, 18 and 17% with diabetes mellitus, respectively). Survival analyses examined the associations between Roma ethnicity and all-cause mortality and death-censored graft loss or death with functioning renal allograft. Results: During the follow-up period, 341 patients (32%) died. Two-hundred eighty (26%) patients died with a functioning graft and 201 patients (19%) returned to dialysis. After multivariable adjustments, Roma ethnicity was associated with 77% higher risk of all-cause mortality (Hazard Ratio (HR): 1.77; 95% confidence interval (CI): 1.02, 3.07), two times higher risk of mortality with functioning graft (2.04 [1.17-3.55]) and 77% higher risk of graft loss (1.77 [1.01-3.13]), respectively. Conclusions Roma ethnicity is independently associated with increased mortality risk and worse graft outcome in kidney transplant recipients. Further studies should identify the factors contributing to worse outcomes among Roma patients.

AB - Background Racial and ethnic disparities among North American patients with chronic kidney disease have received significant attention. In contrast, little is known about health-related outcomes of patients with end-stage renal disease among the Roma minority, also known as gypsies, compared to Caucasian individuals. We prospectively assessed the association between Roma ethnicity and long-term clinical outcomes in kidney transplant recipients. Methods In a prevalent cohort of renal transplant recipients, followed up over a median of 94 months, we prospectively collected socio-demographic, medical (and transplant related) characteristics and laboratory data at baseline from 60 Roma and 1,003 Caucasian patients (mean age 45 (SD = 11) and 49 (SD = 13) years, 33 and 41% women, 18 and 17% with diabetes mellitus, respectively). Survival analyses examined the associations between Roma ethnicity and all-cause mortality and death-censored graft loss or death with functioning renal allograft. Results: During the follow-up period, 341 patients (32%) died. Two-hundred eighty (26%) patients died with a functioning graft and 201 patients (19%) returned to dialysis. After multivariable adjustments, Roma ethnicity was associated with 77% higher risk of all-cause mortality (Hazard Ratio (HR): 1.77; 95% confidence interval (CI): 1.02, 3.07), two times higher risk of mortality with functioning graft (2.04 [1.17-3.55]) and 77% higher risk of graft loss (1.77 [1.01-3.13]), respectively. Conclusions Roma ethnicity is independently associated with increased mortality risk and worse graft outcome in kidney transplant recipients. Further studies should identify the factors contributing to worse outcomes among Roma patients.

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