Safety and outcomes of intravenous thrombolysis in dissection-related ischemic stroke

an international multicenter study and comprehensive meta-analysis of reported case series

Georgios Tsivgoulis, Ramin Zand, Aristeidis H. Katsanos, Vijay K. Sharma, Nitin Goyal, Christos Krogias, Apostolos Safouris, Konstantinos Vadikolias, Konstantinos Voumvourakis, Anne Alexandrov, Marc Malkoff, Andrei Alexandrov

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The safety and efficacy of intravenous thrombolysis (IVT) in dissection-related ischemic stroke (DRIS) has not been established. We sought to determine safety and recovery rates of IVT in DRIS using prospective, international, multicenter data and by conducting a comprehensive meta-analysis of reported case series. We analyzed consecutive DRIS patients treated with IVT according to national guidelines during a 5-year period at six tertiary-care stroke centers, and also conducted a comprehensive review and meta-analysis of all available case series reporting safety outcomes in DRIS treated with IVT according to PRISMA guidelines. A total of 39 DRIS patients (mean age 60 ± 18 years; 59 % men; median NIHSS 13 points, IQR 9–17) received IVT in our multicenter study. Symptomatic intracranial hemorrhage (sICH), in-hospital mortality, complete recanalization, favorable functional outcome (FFO; mRS-score of 0–1) and functional independence (FI; mRS-score of 0–2) were 0 % (adjusted Wald 95 % CI 0–8 %), 10 % (3–24 %), 55 % (40–70 %), 61 % (45–74 %) and 68 % (52–81 %). The pooled sICH and mortality rates in meta-analysis including 10 case series (234 IVT-DRIS patients) were 2 % (0–5 %) and 4 % (0–8 %). The pooled recanalization, FFO and FI rates were 45 % (26–67 %), 41 % (29–54 %) and 61 % (48–72 %), respectively. Substantial heterogeneity was only found for FFO (I 2  = 61 %; p = 0.006). Subsequent meta-regression analysis identified baseline NIHSS and dissection in the posterior circulation as independent predictors of FFO (p < 0.05), accounting for FFO variance across different studies. Our prospective, international data coupled with comprehensive meta-analysis results underscore IVT safety in DRIS, while further independent validation is required in larger observational registries or RCTs.

Original languageEnglish (US)
Pages (from-to)2135-2143
Number of pages9
JournalJournal of Neurology
Volume262
Issue number9
DOIs
StatePublished - Sep 22 2015

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Multicenter Studies
Meta-Analysis
Dissection
Stroke
Safety
Intracranial Hemorrhages
Guidelines
Hospital Mortality
Tertiary Care Centers
Registries
Regression Analysis
Mortality

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Safety and outcomes of intravenous thrombolysis in dissection-related ischemic stroke : an international multicenter study and comprehensive meta-analysis of reported case series. / Tsivgoulis, Georgios; Zand, Ramin; Katsanos, Aristeidis H.; Sharma, Vijay K.; Goyal, Nitin; Krogias, Christos; Safouris, Apostolos; Vadikolias, Konstantinos; Voumvourakis, Konstantinos; Alexandrov, Anne; Malkoff, Marc; Alexandrov, Andrei.

In: Journal of Neurology, Vol. 262, No. 9, 22.09.2015, p. 2135-2143.

Research output: Contribution to journalArticle

Tsivgoulis, Georgios ; Zand, Ramin ; Katsanos, Aristeidis H. ; Sharma, Vijay K. ; Goyal, Nitin ; Krogias, Christos ; Safouris, Apostolos ; Vadikolias, Konstantinos ; Voumvourakis, Konstantinos ; Alexandrov, Anne ; Malkoff, Marc ; Alexandrov, Andrei. / Safety and outcomes of intravenous thrombolysis in dissection-related ischemic stroke : an international multicenter study and comprehensive meta-analysis of reported case series. In: Journal of Neurology. 2015 ; Vol. 262, No. 9. pp. 2135-2143.
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