Safety Evaluation of Sevoflurane as Anesthetic Agent in Mouse Model of Myocardial Ischemic Infarction

Xiang Cheng, Jianglong Hou, Jiaming Liu, Xiaorong Sun, Qin Sheng, Pengfei Han, Yujian Kang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The selection of anesthetics for patients with myocardial infarction is critically challenging. Sevoflurane is a volatile anesthetic gradually used in recent years. The intraoperative hemodynamic stability of sevoflurane was supported by several studies with some suggestions for its use for patients with cardiac events. The present study was undertaken to investigate the effect of sevoflurane on mice with myocardial infarction to evaluate the safety issue of this agent for possible application in patients with myocardial infarction. Mice of 7–12 weeks old were subjected to left anterior descending artery ligation to introduce acute myocardial infarction. The effect of sevoflurane on the hemodynamics was examined in comparison with that of currently available agent etomidate at low and moderate doses. The results showed that sevoflurane caused unstable hemodynamic changes in mice with myocardial infarction at both low and moderate inhaled concentrations relative to low and moderate doses of etomidate. In addition, the relative safety margin estimated from therapeutic index was decreased by 50 % when sevoflurane was used for mice with myocardial infarction relative to control mice, but only decreased by 20 % for etomidate. These analyses indicate that in comparison with currently available agent etomidate, sevoflurane should not be applied to patients with myocardial infarction or other cardiac events.

Original languageEnglish (US)
Pages (from-to)150-156
Number of pages7
JournalCardiovascular Toxicology
Volume17
Issue number2
DOIs
StatePublished - Apr 1 2017
Externally publishedYes

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Anesthetics
Etomidate
Myocardial Infarction
Safety
Hemodynamics
sevoflurane
Patient Selection
Ligation
Arteries

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Toxicology
  • Cardiology and Cardiovascular Medicine

Cite this

Safety Evaluation of Sevoflurane as Anesthetic Agent in Mouse Model of Myocardial Ischemic Infarction. / Cheng, Xiang; Hou, Jianglong; Liu, Jiaming; Sun, Xiaorong; Sheng, Qin; Han, Pengfei; Kang, Yujian.

In: Cardiovascular Toxicology, Vol. 17, No. 2, 01.04.2017, p. 150-156.

Research output: Contribution to journalArticle

Cheng, Xiang ; Hou, Jianglong ; Liu, Jiaming ; Sun, Xiaorong ; Sheng, Qin ; Han, Pengfei ; Kang, Yujian. / Safety Evaluation of Sevoflurane as Anesthetic Agent in Mouse Model of Myocardial Ischemic Infarction. In: Cardiovascular Toxicology. 2017 ; Vol. 17, No. 2. pp. 150-156.
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