Salicylate-mediated increase in urate removal during hemodialysis

Evidence for urate binding to protein in vivo

Arnold Postlethwaite, Robert A. Gutman, William N. Kelley

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The binding of urate to plasma proteins was estimated by an in vitro technique before and after the administration of aspirin to ten patients undergoing intermittent hemodialysis for chronic renal insufficiency. Six of these patients did not have any detectable binding of urate to plasma proteins in vitro either before or after aspirin administration. Aspirin did not have any effect on the removal of urate during hemodialysis in these six subjects. Four patients exhibited binding of urate to plasma proteins in vitro, which was markedly reduced by the administration of aspirin. In these four subjects, the rate of removal of urate during hemodialysis on five different occasions was significantly increased by the administration of aspirin. This increase in the removal of urate is best explained by an aspirin-mediated release of urate from protein-binding sites in vivo. While previous studies have demonstrated that urate binding to plasma proteins occurs in vitro, this study provides the first evidence to suggest that such binding may also occur in vivo.

Original languageEnglish (US)
Pages (from-to)771-777
Number of pages7
JournalMetabolism
Volume23
Issue number8
DOIs
StatePublished - Jan 1 1974
Externally publishedYes

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Salicylates
Uric Acid
Renal Dialysis
Carrier Proteins
Aspirin
Blood Proteins
Chronic Renal Insufficiency
Protein Binding
Binding Sites
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Salicylate-mediated increase in urate removal during hemodialysis : Evidence for urate binding to protein in vivo. / Postlethwaite, Arnold; Gutman, Robert A.; Kelley, William N.

In: Metabolism, Vol. 23, No. 8, 01.01.1974, p. 771-777.

Research output: Contribution to journalArticle

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