Saline, mannitol, and furosemide hydration in acute cisplatin nephrotoxicity: A randomized trial

Joseph T. Santoso, Joseph A. Lucci, Robert L. Coleman, Ilona Schafer, Edward V. Hannigan

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Abstract

Objective: To determine which hydration (saline, saline + mannitol, or saline + furosemide) is associated with least cisplatin nephrotoxicity. Methods: We randomized 49 women who received cisplatin (75 mg/m2 every 3 weeks) into one of the three hydration arms. The 24-h creatinine clearance was measured before and on day 6 after cisplatin infusion. The patients of each arm received 2 1 of saline hydration. In the saline + furosemide arm, 40 mg of furosemide was given after hydration. In the saline + mannitol arm, 50 g of mannitol was mixed with the cisplatin. Results: For the first cycle of chemotherapy, 15 women were randomized to saline, 17 to saline + furosemide, and 17 to saline + mannitol. For each group, the creatinine clearances before cisplatin infusion were (means ± SD, milliliters per minute) 84.5 ± 26.8, 82.5 ± 24.0 and 87.4 ± 25.6, and after cisplatin infusion were 79.1 ± 31.9, 68.7 ± 21.5, and 56.4 ± 22.9, respectively. The decreases in creatinine clearance were similar between the saline group and the saline + furosemide group (P = 0.66), but different between the saline + mannitol group and the saline group (P = 0.02) or the saline + furosemide group (P = 0.02). As each woman received multiple courses of cisplatin, 15 who received saline contributed 41 paired datasets, 17 who received saline + furosemide contributed 49 paired datasets, and 17 who received saline + mannitol contributed 36 paired datasets showed similar patterns. Conclusions: Hydration with saline or saline + furosemide appears to be associated with less cisplatin nephrotoxicity than saline + mannitol.

Original languageEnglish (US)
Pages (from-to)13-18
Number of pages6
JournalCancer Chemotherapy and Pharmacology
Volume52
Issue number1
DOIs
StatePublished - Jul 1 2003

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Furosemide
Mannitol
Hydration
Cisplatin
Creatinine
Chemotherapy
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Oncology
  • Toxicology
  • Pharmacology
  • Cancer Research
  • Pharmacology (medical)

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Saline, mannitol, and furosemide hydration in acute cisplatin nephrotoxicity : A randomized trial. / Santoso, Joseph T.; Lucci, Joseph A.; Coleman, Robert L.; Schafer, Ilona; Hannigan, Edward V.

In: Cancer Chemotherapy and Pharmacology, Vol. 52, No. 1, 01.07.2003, p. 13-18.

Research output: Contribution to journalArticle

Santoso, Joseph T. ; Lucci, Joseph A. ; Coleman, Robert L. ; Schafer, Ilona ; Hannigan, Edward V. / Saline, mannitol, and furosemide hydration in acute cisplatin nephrotoxicity : A randomized trial. In: Cancer Chemotherapy and Pharmacology. 2003 ; Vol. 52, No. 1. pp. 13-18.
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abstract = "Objective: To determine which hydration (saline, saline + mannitol, or saline + furosemide) is associated with least cisplatin nephrotoxicity. Methods: We randomized 49 women who received cisplatin (75 mg/m2 every 3 weeks) into one of the three hydration arms. The 24-h creatinine clearance was measured before and on day 6 after cisplatin infusion. The patients of each arm received 2 1 of saline hydration. In the saline + furosemide arm, 40 mg of furosemide was given after hydration. In the saline + mannitol arm, 50 g of mannitol was mixed with the cisplatin. Results: For the first cycle of chemotherapy, 15 women were randomized to saline, 17 to saline + furosemide, and 17 to saline + mannitol. For each group, the creatinine clearances before cisplatin infusion were (means ± SD, milliliters per minute) 84.5 ± 26.8, 82.5 ± 24.0 and 87.4 ± 25.6, and after cisplatin infusion were 79.1 ± 31.9, 68.7 ± 21.5, and 56.4 ± 22.9, respectively. The decreases in creatinine clearance were similar between the saline group and the saline + furosemide group (P = 0.66), but different between the saline + mannitol group and the saline group (P = 0.02) or the saline + furosemide group (P = 0.02). As each woman received multiple courses of cisplatin, 15 who received saline contributed 41 paired datasets, 17 who received saline + furosemide contributed 49 paired datasets, and 17 who received saline + mannitol contributed 36 paired datasets showed similar patterns. Conclusions: Hydration with saline or saline + furosemide appears to be associated with less cisplatin nephrotoxicity than saline + mannitol.",
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AU - Hannigan, Edward V.

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N2 - Objective: To determine which hydration (saline, saline + mannitol, or saline + furosemide) is associated with least cisplatin nephrotoxicity. Methods: We randomized 49 women who received cisplatin (75 mg/m2 every 3 weeks) into one of the three hydration arms. The 24-h creatinine clearance was measured before and on day 6 after cisplatin infusion. The patients of each arm received 2 1 of saline hydration. In the saline + furosemide arm, 40 mg of furosemide was given after hydration. In the saline + mannitol arm, 50 g of mannitol was mixed with the cisplatin. Results: For the first cycle of chemotherapy, 15 women were randomized to saline, 17 to saline + furosemide, and 17 to saline + mannitol. For each group, the creatinine clearances before cisplatin infusion were (means ± SD, milliliters per minute) 84.5 ± 26.8, 82.5 ± 24.0 and 87.4 ± 25.6, and after cisplatin infusion were 79.1 ± 31.9, 68.7 ± 21.5, and 56.4 ± 22.9, respectively. The decreases in creatinine clearance were similar between the saline group and the saline + furosemide group (P = 0.66), but different between the saline + mannitol group and the saline group (P = 0.02) or the saline + furosemide group (P = 0.02). As each woman received multiple courses of cisplatin, 15 who received saline contributed 41 paired datasets, 17 who received saline + furosemide contributed 49 paired datasets, and 17 who received saline + mannitol contributed 36 paired datasets showed similar patterns. Conclusions: Hydration with saline or saline + furosemide appears to be associated with less cisplatin nephrotoxicity than saline + mannitol.

AB - Objective: To determine which hydration (saline, saline + mannitol, or saline + furosemide) is associated with least cisplatin nephrotoxicity. Methods: We randomized 49 women who received cisplatin (75 mg/m2 every 3 weeks) into one of the three hydration arms. The 24-h creatinine clearance was measured before and on day 6 after cisplatin infusion. The patients of each arm received 2 1 of saline hydration. In the saline + furosemide arm, 40 mg of furosemide was given after hydration. In the saline + mannitol arm, 50 g of mannitol was mixed with the cisplatin. Results: For the first cycle of chemotherapy, 15 women were randomized to saline, 17 to saline + furosemide, and 17 to saline + mannitol. For each group, the creatinine clearances before cisplatin infusion were (means ± SD, milliliters per minute) 84.5 ± 26.8, 82.5 ± 24.0 and 87.4 ± 25.6, and after cisplatin infusion were 79.1 ± 31.9, 68.7 ± 21.5, and 56.4 ± 22.9, respectively. The decreases in creatinine clearance were similar between the saline group and the saline + furosemide group (P = 0.66), but different between the saline + mannitol group and the saline group (P = 0.02) or the saline + furosemide group (P = 0.02). As each woman received multiple courses of cisplatin, 15 who received saline contributed 41 paired datasets, 17 who received saline + furosemide contributed 49 paired datasets, and 17 who received saline + mannitol contributed 36 paired datasets showed similar patterns. Conclusions: Hydration with saline or saline + furosemide appears to be associated with less cisplatin nephrotoxicity than saline + mannitol.

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