Salivary epidermal growth factor concentration in thyrotoxicosis

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Epidermal growth factor (EGF) was first isolated from the mouse submaxillary gland, and later from human urine. The synthesis of mouse EGF is stimulated by thyroid hormone and inhibited by antithyroid therapy. EGF in turn stimulates the growth of thyroid cells. The objective of the present study was to determine whether salivary EGF levels are affected by thyroid hormone level in man. Unstimulated saliva was obtained from 13 (1 male, 12 females) untreated thyrotoxic patients (age 19-64 yr) and from 21 (2 males, 19 females) healthy controls (age 19-68 yr). After centrifugation at 1000 x g, the supernatants were assayed for human (h) EGF in a homologous radioimmunoassay. The mean ± SEM concentration of hEGF was 0.42 ± 0.05 nmol/L in controls compared with 0.71 ± 0.25 nmol/L in thyrotoxic patients (p > 0.05). Thyrotoxic patients with goiter secreted significantly higher concentrations of hEGF (0.92 ± 0.24 nmol/L) in saliva than did euthyroid controls or nongoitrous thyrotoxic patients (0.31 ± 0.11 nmol/L, p < 0.01).

Original languageEnglish (US)
Pages (from-to)643-645
Number of pages3
JournalNutrition
Volume11
Issue number5 SUPPL.
StatePublished - 1995
Externally publishedYes

Fingerprint

Thyrotoxicosis
Epidermal Growth Factor
Thyroid Hormones
Saliva
Submandibular Gland
Goiter
Centrifugation
Radioimmunoassay
Thyroid Gland
Urine
Growth

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Surgery

Cite this

Salivary epidermal growth factor concentration in thyrotoxicosis. / Dagogo-Jack, Samuel.

In: Nutrition, Vol. 11, No. 5 SUPPL., 1995, p. 643-645.

Research output: Contribution to journalArticle

@article{f1d2655d9ad445719eaa0c0d42452896,
title = "Salivary epidermal growth factor concentration in thyrotoxicosis",
abstract = "Epidermal growth factor (EGF) was first isolated from the mouse submaxillary gland, and later from human urine. The synthesis of mouse EGF is stimulated by thyroid hormone and inhibited by antithyroid therapy. EGF in turn stimulates the growth of thyroid cells. The objective of the present study was to determine whether salivary EGF levels are affected by thyroid hormone level in man. Unstimulated saliva was obtained from 13 (1 male, 12 females) untreated thyrotoxic patients (age 19-64 yr) and from 21 (2 males, 19 females) healthy controls (age 19-68 yr). After centrifugation at 1000 x g, the supernatants were assayed for human (h) EGF in a homologous radioimmunoassay. The mean ± SEM concentration of hEGF was 0.42 ± 0.05 nmol/L in controls compared with 0.71 ± 0.25 nmol/L in thyrotoxic patients (p > 0.05). Thyrotoxic patients with goiter secreted significantly higher concentrations of hEGF (0.92 ± 0.24 nmol/L) in saliva than did euthyroid controls or nongoitrous thyrotoxic patients (0.31 ± 0.11 nmol/L, p < 0.01).",
author = "Samuel Dagogo-Jack",
year = "1995",
language = "English (US)",
volume = "11",
pages = "643--645",
journal = "Nutrition",
issn = "0899-9007",
publisher = "Elsevier Inc.",
number = "5 SUPPL.",

}

TY - JOUR

T1 - Salivary epidermal growth factor concentration in thyrotoxicosis

AU - Dagogo-Jack, Samuel

PY - 1995

Y1 - 1995

N2 - Epidermal growth factor (EGF) was first isolated from the mouse submaxillary gland, and later from human urine. The synthesis of mouse EGF is stimulated by thyroid hormone and inhibited by antithyroid therapy. EGF in turn stimulates the growth of thyroid cells. The objective of the present study was to determine whether salivary EGF levels are affected by thyroid hormone level in man. Unstimulated saliva was obtained from 13 (1 male, 12 females) untreated thyrotoxic patients (age 19-64 yr) and from 21 (2 males, 19 females) healthy controls (age 19-68 yr). After centrifugation at 1000 x g, the supernatants were assayed for human (h) EGF in a homologous radioimmunoassay. The mean ± SEM concentration of hEGF was 0.42 ± 0.05 nmol/L in controls compared with 0.71 ± 0.25 nmol/L in thyrotoxic patients (p > 0.05). Thyrotoxic patients with goiter secreted significantly higher concentrations of hEGF (0.92 ± 0.24 nmol/L) in saliva than did euthyroid controls or nongoitrous thyrotoxic patients (0.31 ± 0.11 nmol/L, p < 0.01).

AB - Epidermal growth factor (EGF) was first isolated from the mouse submaxillary gland, and later from human urine. The synthesis of mouse EGF is stimulated by thyroid hormone and inhibited by antithyroid therapy. EGF in turn stimulates the growth of thyroid cells. The objective of the present study was to determine whether salivary EGF levels are affected by thyroid hormone level in man. Unstimulated saliva was obtained from 13 (1 male, 12 females) untreated thyrotoxic patients (age 19-64 yr) and from 21 (2 males, 19 females) healthy controls (age 19-68 yr). After centrifugation at 1000 x g, the supernatants were assayed for human (h) EGF in a homologous radioimmunoassay. The mean ± SEM concentration of hEGF was 0.42 ± 0.05 nmol/L in controls compared with 0.71 ± 0.25 nmol/L in thyrotoxic patients (p > 0.05). Thyrotoxic patients with goiter secreted significantly higher concentrations of hEGF (0.92 ± 0.24 nmol/L) in saliva than did euthyroid controls or nongoitrous thyrotoxic patients (0.31 ± 0.11 nmol/L, p < 0.01).

UR - http://www.scopus.com/inward/record.url?scp=0029559151&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029559151&partnerID=8YFLogxK

M3 - Article

VL - 11

SP - 643

EP - 645

JO - Nutrition

JF - Nutrition

SN - 0899-9007

IS - 5 SUPPL.

ER -