Saralasin Acetate Test in Renal Transplant Hypertension

Report of 17 Cases and a Review of the Literature

Edward T. Zawada, Sandra J. Green, Michael D. Johnson, Emanuel R. Reinitz, Wael Mauakkassa, Domenic Sica, Mitchell Goldman

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The saralasin acetate test was performed in 17 hypertensive patients with renal transplants. These results were compared with 39 previously published reports of transplant patients who had been tested in the same manner. Eighty-two percent of our patients had a positive saralasin acetate test, suggesting renin-dependent hypertension. Baseline plasma renin activity (PRA) was significantly higher in patients with positive tests (6.96±1.75 v 2.88±0.53 ng/mL/hr). However, positive tests were obtained in several patients who had normoreninemia, and PRA levels did not correlate with the magnitude of vasodepressor BP response to saralasin. Transplant artery stenosis, acute rejection, and chronic rejection were the most common posttransplant complications associated with a positive test, but several patients had hypertension alone. While highly sensitive for renin-dependent hypertension posttransplantation, the test had poor specificity for identification of any one cause of posttransplant hypertension.

Original languageEnglish (US)
Pages (from-to)65-68
Number of pages4
JournalArchives of Internal Medicine
Volume144
Issue number1
DOIs
StatePublished - Jan 1 1984
Externally publishedYes

Fingerprint

Saralasin
Renal Hypertension
Transplants
Renin
Hypertension
Pathologic Constriction
Arteries
Kidney

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Saralasin Acetate Test in Renal Transplant Hypertension : Report of 17 Cases and a Review of the Literature. / Zawada, Edward T.; Green, Sandra J.; Johnson, Michael D.; Reinitz, Emanuel R.; Mauakkassa, Wael; Sica, Domenic; Goldman, Mitchell.

In: Archives of Internal Medicine, Vol. 144, No. 1, 01.01.1984, p. 65-68.

Research output: Contribution to journalArticle

Zawada, Edward T. ; Green, Sandra J. ; Johnson, Michael D. ; Reinitz, Emanuel R. ; Mauakkassa, Wael ; Sica, Domenic ; Goldman, Mitchell. / Saralasin Acetate Test in Renal Transplant Hypertension : Report of 17 Cases and a Review of the Literature. In: Archives of Internal Medicine. 1984 ; Vol. 144, No. 1. pp. 65-68.
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