Screening for coronary artery disease in patients with diabetes

Jeroen J. Bax, Lawrence H. Young, Robert L. Frye, Robert O. Bonow, Helmut O. Steinberg, Eugene J. Barrett

Research output: Contribution to journalArticle

174 Citations (Scopus)

Abstract

Coronary artery disease (CAD) accounts for a large fraction of the morbidity, mortality, and cost of diabetes. Recognizing this, nearly 10 years ago the American Diabetes Association published a consensus recommendation that clinicians consider a risk factor- guided screening approach to early diagnosis of CAD in both symptomatic and asymptomatic patients. Subsequent clinical trial results have not supported those recommendations. Since the prior consensus statement, newer imaging methods, such as coronary artery calcium scoring and noninvasive angiography with computed tomography (CT) techniques, have come into use. These technologies, which allow quantitation of atherosclerotic burden and can predict risk of cardiac events, might provide an approach to more widespread coronary atherosclerosis screening. However, over this same time interval, there has been recognition of diabetes as a cardiovascular disease (CVD) equivalent, clear demonstration that medical interventions should provide primary and secondary CVD risk reduction in diabetic populations, and suggestive evidence that percutaneous coronary revascularization may not provide additive survival benefit to intensive medical management in patients with stable CAD. This additional evidence raises the question of whether documenting asymptomatic atherosclerosis or ischemia in people with diabetes is warranted. More data addressing this issue will be forthcoming from the BARI 2-D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) trial. Until then, for patients with type 2 diabetes who are asymptomatic for CAD, we recommend that testing for atherosclerosis or ischemia, perhaps with cardiac CT as the initial test, be reserved for those in whom medical treatment goals cannot be met and for selected individuals in whom there is strong clinical suspicion of very-high-risk CAD. Better approaches to identify such individuals based on readily obtained clinical variables are sorely needed.

Original languageEnglish (US)
Pages (from-to)2729-2736
Number of pages8
JournalDiabetes care
Volume30
Issue number10
DOIs
StatePublished - Oct 1 2007

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Coronary Artery Disease
Atherosclerosis
Consensus
Cardiovascular Diseases
Ischemia
Percutaneous Coronary Intervention
Risk Reduction Behavior
Angioplasty
Type 2 Diabetes Mellitus
Early Diagnosis
Coronary Vessels
Tomography
Clinical Trials
Calcium
Technology
Morbidity
Costs and Cost Analysis
Survival
Mortality
Population

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Bax, J. J., Young, L. H., Frye, R. L., Bonow, R. O., Steinberg, H. O., & Barrett, E. J. (2007). Screening for coronary artery disease in patients with diabetes. Diabetes care, 30(10), 2729-2736. https://doi.org/10.2337/dc07-9927

Screening for coronary artery disease in patients with diabetes. / Bax, Jeroen J.; Young, Lawrence H.; Frye, Robert L.; Bonow, Robert O.; Steinberg, Helmut O.; Barrett, Eugene J.

In: Diabetes care, Vol. 30, No. 10, 01.10.2007, p. 2729-2736.

Research output: Contribution to journalArticle

Bax, JJ, Young, LH, Frye, RL, Bonow, RO, Steinberg, HO & Barrett, EJ 2007, 'Screening for coronary artery disease in patients with diabetes', Diabetes care, vol. 30, no. 10, pp. 2729-2736. https://doi.org/10.2337/dc07-9927
Bax JJ, Young LH, Frye RL, Bonow RO, Steinberg HO, Barrett EJ. Screening for coronary artery disease in patients with diabetes. Diabetes care. 2007 Oct 1;30(10):2729-2736. https://doi.org/10.2337/dc07-9927
Bax, Jeroen J. ; Young, Lawrence H. ; Frye, Robert L. ; Bonow, Robert O. ; Steinberg, Helmut O. ; Barrett, Eugene J. / Screening for coronary artery disease in patients with diabetes. In: Diabetes care. 2007 ; Vol. 30, No. 10. pp. 2729-2736.
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