Second prize

Recurrence rates after percutaneous and laparoscopic renal cryoablation of small renal masses: Does the approach make a difference?

Kurt H. Strom, Ithaar Derweesh, Sean P. Stroup, John B. Malcolm, James L'Esperance, Robert Wake, Robert Gold, Michael Fabrizio, Kerrin Palazzi-Churas, Xiao Gu, Carson Wong

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background and Purpose: As radiologic detection of small renal masses increases, patients are increasingly offered percutaneous renal cryoablation (PRC) or transperitoneal laparoscopic renal cryoablation (TLRC). This multicenter experience compares these approaches. Patients and Methods: Between September 1998 and May 2010, review of our PRC and TLRC experience was performed. Patients with ≥12-month follow-up were included for analysis. Post-treatment surveillance consisted of laboratory studies and imaging at regular intervals. Treatment failure was considered if persistent mass enhancement or interval tumor growth was radiographically evident. Repeated biopsy and re-treatment were recommended in the event of recurrence. Results: Sixty-one patients underwent PRC and 84 patients underwent TLRC. No significant differences were noted with respect to demographic factors. Mean tumor size was 2.7 ± 1.1 cm (PRC) and 2.5 ± 0.8 (TLRC) cm (P = 0.090). Mean follow-up was 31.0 ± 15.9 months (PRC) and 42.3 ± 21.2 (TLRC) months (P = 0.008), with local tumor recurrence noted in 10/61 (16.4%) PRC and 5/84 (5.9%) TLRC (P = 0.042). For PRC, disease-free survival (DFS) and overall survival (OS) were 93.7% and 88.9%, respectively, with four patients having evidence of disease at last follow-up. DFS and OS were 91.7% and 89.3% for TLRC, with seven patients having evidence of disease at last follow-up. DFS (P = 0.654) and OS (P = 0.939) were similar. Conclusions: In this multicenter study of well-matched cohorts, PRC had higher primary treatment failure rates than TLRC. While no differences were noted between DFS and OS, analysis is limited by intermediate follow-up. Further study is necessary to discern reasons for the higher recurrence rates in PRC and to determine what long-term consequences exist.

Original languageEnglish (US)
Pages (from-to)371-375
Number of pages5
JournalJournal of Endourology
Volume25
Issue number3
DOIs
StatePublished - Mar 1 2011

Fingerprint

Cryosurgery
Kidney
Recurrence
Disease-Free Survival
Treatment Failure
Survival
Neoplasms

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Second prize : Recurrence rates after percutaneous and laparoscopic renal cryoablation of small renal masses: Does the approach make a difference? / Strom, Kurt H.; Derweesh, Ithaar; Stroup, Sean P.; Malcolm, John B.; L'Esperance, James; Wake, Robert; Gold, Robert; Fabrizio, Michael; Palazzi-Churas, Kerrin; Gu, Xiao; Wong, Carson.

In: Journal of Endourology, Vol. 25, No. 3, 01.03.2011, p. 371-375.

Research output: Contribution to journalArticle

Strom, KH, Derweesh, I, Stroup, SP, Malcolm, JB, L'Esperance, J, Wake, R, Gold, R, Fabrizio, M, Palazzi-Churas, K, Gu, X & Wong, C 2011, 'Second prize: Recurrence rates after percutaneous and laparoscopic renal cryoablation of small renal masses: Does the approach make a difference?', Journal of Endourology, vol. 25, no. 3, pp. 371-375. https://doi.org/10.1089/end.2010.0239
Strom, Kurt H. ; Derweesh, Ithaar ; Stroup, Sean P. ; Malcolm, John B. ; L'Esperance, James ; Wake, Robert ; Gold, Robert ; Fabrizio, Michael ; Palazzi-Churas, Kerrin ; Gu, Xiao ; Wong, Carson. / Second prize : Recurrence rates after percutaneous and laparoscopic renal cryoablation of small renal masses: Does the approach make a difference?. In: Journal of Endourology. 2011 ; Vol. 25, No. 3. pp. 371-375.
@article{c54b307051ff4307ab0294dc70a46997,
title = "Second prize: Recurrence rates after percutaneous and laparoscopic renal cryoablation of small renal masses: Does the approach make a difference?",
abstract = "Background and Purpose: As radiologic detection of small renal masses increases, patients are increasingly offered percutaneous renal cryoablation (PRC) or transperitoneal laparoscopic renal cryoablation (TLRC). This multicenter experience compares these approaches. Patients and Methods: Between September 1998 and May 2010, review of our PRC and TLRC experience was performed. Patients with ≥12-month follow-up were included for analysis. Post-treatment surveillance consisted of laboratory studies and imaging at regular intervals. Treatment failure was considered if persistent mass enhancement or interval tumor growth was radiographically evident. Repeated biopsy and re-treatment were recommended in the event of recurrence. Results: Sixty-one patients underwent PRC and 84 patients underwent TLRC. No significant differences were noted with respect to demographic factors. Mean tumor size was 2.7 ± 1.1 cm (PRC) and 2.5 ± 0.8 (TLRC) cm (P = 0.090). Mean follow-up was 31.0 ± 15.9 months (PRC) and 42.3 ± 21.2 (TLRC) months (P = 0.008), with local tumor recurrence noted in 10/61 (16.4{\%}) PRC and 5/84 (5.9{\%}) TLRC (P = 0.042). For PRC, disease-free survival (DFS) and overall survival (OS) were 93.7{\%} and 88.9{\%}, respectively, with four patients having evidence of disease at last follow-up. DFS and OS were 91.7{\%} and 89.3{\%} for TLRC, with seven patients having evidence of disease at last follow-up. DFS (P = 0.654) and OS (P = 0.939) were similar. Conclusions: In this multicenter study of well-matched cohorts, PRC had higher primary treatment failure rates than TLRC. While no differences were noted between DFS and OS, analysis is limited by intermediate follow-up. Further study is necessary to discern reasons for the higher recurrence rates in PRC and to determine what long-term consequences exist.",
author = "Strom, {Kurt H.} and Ithaar Derweesh and Stroup, {Sean P.} and Malcolm, {John B.} and James L'Esperance and Robert Wake and Robert Gold and Michael Fabrizio and Kerrin Palazzi-Churas and Xiao Gu and Carson Wong",
year = "2011",
month = "3",
day = "1",
doi = "10.1089/end.2010.0239",
language = "English (US)",
volume = "25",
pages = "371--375",
journal = "Journal of Endourology",
issn = "0892-7790",
publisher = "Mary Ann Liebert Inc.",
number = "3",

}

TY - JOUR

T1 - Second prize

T2 - Recurrence rates after percutaneous and laparoscopic renal cryoablation of small renal masses: Does the approach make a difference?

AU - Strom, Kurt H.

AU - Derweesh, Ithaar

AU - Stroup, Sean P.

AU - Malcolm, John B.

AU - L'Esperance, James

AU - Wake, Robert

AU - Gold, Robert

AU - Fabrizio, Michael

AU - Palazzi-Churas, Kerrin

AU - Gu, Xiao

AU - Wong, Carson

PY - 2011/3/1

Y1 - 2011/3/1

N2 - Background and Purpose: As radiologic detection of small renal masses increases, patients are increasingly offered percutaneous renal cryoablation (PRC) or transperitoneal laparoscopic renal cryoablation (TLRC). This multicenter experience compares these approaches. Patients and Methods: Between September 1998 and May 2010, review of our PRC and TLRC experience was performed. Patients with ≥12-month follow-up were included for analysis. Post-treatment surveillance consisted of laboratory studies and imaging at regular intervals. Treatment failure was considered if persistent mass enhancement or interval tumor growth was radiographically evident. Repeated biopsy and re-treatment were recommended in the event of recurrence. Results: Sixty-one patients underwent PRC and 84 patients underwent TLRC. No significant differences were noted with respect to demographic factors. Mean tumor size was 2.7 ± 1.1 cm (PRC) and 2.5 ± 0.8 (TLRC) cm (P = 0.090). Mean follow-up was 31.0 ± 15.9 months (PRC) and 42.3 ± 21.2 (TLRC) months (P = 0.008), with local tumor recurrence noted in 10/61 (16.4%) PRC and 5/84 (5.9%) TLRC (P = 0.042). For PRC, disease-free survival (DFS) and overall survival (OS) were 93.7% and 88.9%, respectively, with four patients having evidence of disease at last follow-up. DFS and OS were 91.7% and 89.3% for TLRC, with seven patients having evidence of disease at last follow-up. DFS (P = 0.654) and OS (P = 0.939) were similar. Conclusions: In this multicenter study of well-matched cohorts, PRC had higher primary treatment failure rates than TLRC. While no differences were noted between DFS and OS, analysis is limited by intermediate follow-up. Further study is necessary to discern reasons for the higher recurrence rates in PRC and to determine what long-term consequences exist.

AB - Background and Purpose: As radiologic detection of small renal masses increases, patients are increasingly offered percutaneous renal cryoablation (PRC) or transperitoneal laparoscopic renal cryoablation (TLRC). This multicenter experience compares these approaches. Patients and Methods: Between September 1998 and May 2010, review of our PRC and TLRC experience was performed. Patients with ≥12-month follow-up were included for analysis. Post-treatment surveillance consisted of laboratory studies and imaging at regular intervals. Treatment failure was considered if persistent mass enhancement or interval tumor growth was radiographically evident. Repeated biopsy and re-treatment were recommended in the event of recurrence. Results: Sixty-one patients underwent PRC and 84 patients underwent TLRC. No significant differences were noted with respect to demographic factors. Mean tumor size was 2.7 ± 1.1 cm (PRC) and 2.5 ± 0.8 (TLRC) cm (P = 0.090). Mean follow-up was 31.0 ± 15.9 months (PRC) and 42.3 ± 21.2 (TLRC) months (P = 0.008), with local tumor recurrence noted in 10/61 (16.4%) PRC and 5/84 (5.9%) TLRC (P = 0.042). For PRC, disease-free survival (DFS) and overall survival (OS) were 93.7% and 88.9%, respectively, with four patients having evidence of disease at last follow-up. DFS and OS were 91.7% and 89.3% for TLRC, with seven patients having evidence of disease at last follow-up. DFS (P = 0.654) and OS (P = 0.939) were similar. Conclusions: In this multicenter study of well-matched cohorts, PRC had higher primary treatment failure rates than TLRC. While no differences were noted between DFS and OS, analysis is limited by intermediate follow-up. Further study is necessary to discern reasons for the higher recurrence rates in PRC and to determine what long-term consequences exist.

UR - http://www.scopus.com/inward/record.url?scp=79952654289&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952654289&partnerID=8YFLogxK

U2 - 10.1089/end.2010.0239

DO - 10.1089/end.2010.0239

M3 - Article

VL - 25

SP - 371

EP - 375

JO - Journal of Endourology

JF - Journal of Endourology

SN - 0892-7790

IS - 3

ER -