Seizure prediction and detection via phase and amplitude lock values

Mark Myers, Akshay Padmanabha, Gahangir Hossain, Amy Curry, Charles D. Blaha

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A robust seizure prediction methodology would enable a “closed-loop” system that would only activate as impending seizure activity is detected. Such a system would eliminate ongoing stimulation to the brain, thereby eliminating such side effects as coughing, hoarseness, voice alteration, and paresthesias (Murphy et al. 1998; Ben-Menachem, 2001), while preserving overall battery life of the system. The seizure prediction and detection algorithm uses Phase/Amplitude Lock Values (PLV/ALV) which calculate the difference of phase and amplitude between electroencephalogram (EEG) electrodes local and remote to the epileptic event. PLV is used as the seizure prediction marker and signifies the emergence of abnormal neuronal activations through local neuron populations. PLV/ALVs are used as seizure detection markers to demarcate the seizure event, or when the local seizure event has propagated throughout the brain turning into a grand-mal event. We verify the performance of this methodology against the “CHB-MIT Scalp EEG Database” which features seizure attributes for testing. Through this testing, we can demonstrate a high degree of sensivity and precision of our methodology between pre-ictal and ictal events.

Original languageEnglish (US)
Article number80
JournalFrontiers in Human Neuroscience
Volume10
Issue numberMAR2016
DOIs
StatePublished - Mar 8 2016

Fingerprint

Seizures
Electroencephalography
Stroke
Hoarseness
Paresthesia
Brain
Scalp
Electrodes
Databases
Neurons
Population

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Seizure prediction and detection via phase and amplitude lock values. / Myers, Mark; Padmanabha, Akshay; Hossain, Gahangir; Curry, Amy; Blaha, Charles D.

In: Frontiers in Human Neuroscience, Vol. 10, No. MAR2016, 80, 08.03.2016.

Research output: Contribution to journalArticle

Myers, Mark ; Padmanabha, Akshay ; Hossain, Gahangir ; Curry, Amy ; Blaha, Charles D. / Seizure prediction and detection via phase and amplitude lock values. In: Frontiers in Human Neuroscience. 2016 ; Vol. 10, No. MAR2016.
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