Seizure prophylaxis in neurocritical care

A review of evidence-based support

Anthony Rowe, Haley Goodwin, Gretchen M. Brophy, Jennifer Bushwitz, Amber Castle, David Deen, Dachelle Johnson, Christine Lesch, Norah Liang, Emily Potter, Christina Roels, Karen Samaan, Denise H. Rhoney

Research output: Contribution to journalReview article

30 Citations (Scopus)

Abstract

Seizures are a well-described complication of acute brain injury and neurosurgery. Antiepileptic drugs (AEDs) are frequently utilized for seizure prophylaxis in neurocritical care patients. In this review, the Neurocritical Care Society Pharmacy Section describes the evidence associated with the use of AEDs for seizure prophylaxis in patients with intracerebral tumors, traumatic brain injury, aneurysmal subarachnoid hemorrhage, craniotomy, ischemic stroke, and intracerebral hemorrhage. Clear evidence indicates that the short-term use of AEDs for seizure prophylaxis in patients with traumatic brain injury and aneurysmal subarachnoid hemorrhage may be beneficial; however, evidence to support the use of AEDs in other disease states is less clear.

Original languageEnglish (US)
Pages (from-to)396-409
Number of pages14
JournalPharmacotherapy
Volume34
Issue number4
DOIs
StatePublished - Jan 1 2014

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Anticonvulsants
Seizures
Subarachnoid Hemorrhage
Craniotomy
Cerebral Hemorrhage
Neurosurgery
Brain Injuries
Patient Care
Stroke
Neoplasms
Traumatic Brain Injury

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)

Cite this

Rowe, A., Goodwin, H., Brophy, G. M., Bushwitz, J., Castle, A., Deen, D., ... Rhoney, D. H. (2014). Seizure prophylaxis in neurocritical care: A review of evidence-based support. Pharmacotherapy, 34(4), 396-409. https://doi.org/10.1002/phar.1374

Seizure prophylaxis in neurocritical care : A review of evidence-based support. / Rowe, Anthony; Goodwin, Haley; Brophy, Gretchen M.; Bushwitz, Jennifer; Castle, Amber; Deen, David; Johnson, Dachelle; Lesch, Christine; Liang, Norah; Potter, Emily; Roels, Christina; Samaan, Karen; Rhoney, Denise H.

In: Pharmacotherapy, Vol. 34, No. 4, 01.01.2014, p. 396-409.

Research output: Contribution to journalReview article

Rowe, A, Goodwin, H, Brophy, GM, Bushwitz, J, Castle, A, Deen, D, Johnson, D, Lesch, C, Liang, N, Potter, E, Roels, C, Samaan, K & Rhoney, DH 2014, 'Seizure prophylaxis in neurocritical care: A review of evidence-based support', Pharmacotherapy, vol. 34, no. 4, pp. 396-409. https://doi.org/10.1002/phar.1374
Rowe A, Goodwin H, Brophy GM, Bushwitz J, Castle A, Deen D et al. Seizure prophylaxis in neurocritical care: A review of evidence-based support. Pharmacotherapy. 2014 Jan 1;34(4):396-409. https://doi.org/10.1002/phar.1374
Rowe, Anthony ; Goodwin, Haley ; Brophy, Gretchen M. ; Bushwitz, Jennifer ; Castle, Amber ; Deen, David ; Johnson, Dachelle ; Lesch, Christine ; Liang, Norah ; Potter, Emily ; Roels, Christina ; Samaan, Karen ; Rhoney, Denise H. / Seizure prophylaxis in neurocritical care : A review of evidence-based support. In: Pharmacotherapy. 2014 ; Vol. 34, No. 4. pp. 396-409.
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