Selective attenuation by perivascular blood of prostanoid-dependent cerebrovascular dilation in piglets

David W. Busija, Charles Leffler

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Cerebral hemorrhagic insults are common in neonates. However, the consequences of intracranial blood on cerebral hemodynamics are poorly understood. We examined the effects of perivascular blood on cerebrovascular dilator responses in 29 piglets. Fresh, autologous blood (n=15) or cerebrospinal fluid (n= 14) was placed under the dura mater over the parietal cortex, and the piglets were allowed to recover from anesthesia. One to four days later, a closed cranial window was placed over the parietal cortex and pial arteriolar responses to arterial hypercapnia (Paco2>55 mm Hg), hemorrhagic hypotension (mean arterial blood pressure <35 mm Hg), or topical application of 10-6 and 10-4 M isoproterenol were determined. Pial arterioles in the cerebrospinal fluid group dilated 27±4% (mean±SEM) (n=ll) in response to hypercapnia, 26±5% (n=9) in response to hypotension, and 26±3% in response to 10-6M and 40±4% in response to 10-4M isoproterenol (n=ll). In the group in which blood was placed on the parietal cortex, pial arterioles did not dilate significantly in response to hypercapnia (8±3%, n = ll) or hypotension (2±5%, n = 13) but dilated normally In response to isoproterenol (25±5% in response to 10-4 M and 36±7% in response to 10-4 M, n = 13). We conclude that prolonged contact of pial arterioles with extravascular blood selectively attenuates cerebrovascular dilation in piglets.

Original languageEnglish (US)
Pages (from-to)484-488
Number of pages5
JournalStroke
Volume22
Issue number4
DOIs
StatePublished - Jan 1 1991

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Prostaglandins
Dilatation
Parietal Lobe
Hypercapnia
Arterioles
Isoproterenol
Hypotension
Cerebrospinal Fluid
Arterial Pressure
Dura Mater
Anesthesia
Hemodynamics

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Selective attenuation by perivascular blood of prostanoid-dependent cerebrovascular dilation in piglets. / Busija, David W.; Leffler, Charles.

In: Stroke, Vol. 22, No. 4, 01.01.1991, p. 484-488.

Research output: Contribution to journalArticle

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