Selective elimination of cerebellar output in the genetically dystonic rat

Mark Ledoux, Joan F. Lorden, Jareen Meinzen-Derr

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The genetically dystonic (dt) rat, an autosomal recessive mutant, exhibits a progressive motor syndrome that resembles the generalized idiopathic dystonia seen in humans. Even with supportive measures,dt rats die before reaching maturity. A total cerebellectomy that includes the dorsal portions of the lateral vestibular nuclei (dLV) eliminates the dystonic motor syndrome of thedt rats, greatly improves motor function, and prevents early death. The selective elimination of cerebellar nuclei was used to determine the cerebellar components critical to the mutant's motor syndrome. Bilateral electrolytic and/or excitatory amino acid lesions of the medial cerebellar nucleus, nucleus interpositus, lateral cerebellar nucleus and dLV were created in separate groups of 15-day-olddt rats. Rats were observed for the presence of abnormal motor signs (falls, twists, clasps, pivots) and tested on several measures of motor performance (activity, climbing, righting, homing, hanging) before surgery and again on Postnatal Day 20. All nuclear lesions produced significant improvements in motor function and decreases in the frequency of abnormal motor signs. Electrolytic lesions of the dLV were associated with the greatest improvements.

Original languageEnglish (US)
Pages (from-to)91-103
Number of pages13
JournalBrain Research
Volume697
Issue number1-2
DOIs
StatePublished - Oct 30 1995

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Cerebellar Nuclei
Lateral Vestibular Nucleus
Excitatory Amino Acids
Dystonia
Motor Activity

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Selective elimination of cerebellar output in the genetically dystonic rat. / Ledoux, Mark; Lorden, Joan F.; Meinzen-Derr, Jareen.

In: Brain Research, Vol. 697, No. 1-2, 30.10.1995, p. 91-103.

Research output: Contribution to journalArticle

Ledoux, Mark ; Lorden, Joan F. ; Meinzen-Derr, Jareen. / Selective elimination of cerebellar output in the genetically dystonic rat. In: Brain Research. 1995 ; Vol. 697, No. 1-2. pp. 91-103.
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