Selective esterifications of primary alcohols in a water-containing solvent

Yong Wang, Bilal A. Aleiwi, Qinghui Wang, Michio Kurosu

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Oxyma and an oxyma derivative, (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 2-cyano-2-(hydroxyimino)acetate (5b), displayed a remarkable effect on selective esterifications of primary alcohols. A wide range of carboxylic acids could be esterified with primary alcohols by using EDCI, NaHCO3, and Oxyma or Oxyma derivative 5b in 5% H2O-CH3CN. Oxyma derivative 5b is particularly useful, since it could be removed after the reaction via a simple basic or an acidic aqueous workup procedure.

Original languageEnglish (US)
Pages (from-to)4910-4913
Number of pages4
JournalOrganic letters
Volume14
Issue number18
DOIs
StatePublished - Sep 21 2012

Fingerprint

Esterification
alcohols
Alcohols
Water
carboxylic acids
water
acetates
Derivatives
Carboxylic Acids
Acetates
oxyma

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Selective esterifications of primary alcohols in a water-containing solvent. / Wang, Yong; Aleiwi, Bilal A.; Wang, Qinghui; Kurosu, Michio.

In: Organic letters, Vol. 14, No. 18, 21.09.2012, p. 4910-4913.

Research output: Contribution to journalArticle

Wang, Yong ; Aleiwi, Bilal A. ; Wang, Qinghui ; Kurosu, Michio. / Selective esterifications of primary alcohols in a water-containing solvent. In: Organic letters. 2012 ; Vol. 14, No. 18. pp. 4910-4913.
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