Self-administration in rats allowed unlimited access to nicotine

James D. Valentine, Jonathan S. Hokanson, Shannon G. Matta, Burt Sharp

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

The purpose of the present study was to develop an animal model of nicotine self-administration that more closely approximates the conditions of human nicotine use than do existing models. In most nicotine self-administration models, rats acquire self-administration during brief daily sessions in which rapid injections of a relatively high dose of the drug, 0.03 mg/kg, serve as the reinforcer. The present study examined nicotine self-administration in rats that acquired the behavior while having virtually unlimited access to injections of a relatively low dose of the drug; the rats did not have any prior operant training or shaping. Under these conditions, rats readily acquire nicotine self-administration at doses at least as low as 0.00375 mg/kg per injection, and they self-administer throughout the active portion of their light cycle. The daily nicotine intake of rats, which ranged from 0.18 to 1.38 mg/kg per day, appears to be comparable to that of human smokers.

Original languageEnglish (US)
Pages (from-to)300-304
Number of pages5
JournalPsychopharmacology
Volume133
Issue number3
DOIs
StatePublished - Oct 28 1997

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Self Administration
Nicotine
Injections
Photoperiod
Pharmaceutical Preparations
Animal Models

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Self-administration in rats allowed unlimited access to nicotine. / Valentine, James D.; Hokanson, Jonathan S.; Matta, Shannon G.; Sharp, Burt.

In: Psychopharmacology, Vol. 133, No. 3, 28.10.1997, p. 300-304.

Research output: Contribution to journalArticle

Valentine, James D. ; Hokanson, Jonathan S. ; Matta, Shannon G. ; Sharp, Burt. / Self-administration in rats allowed unlimited access to nicotine. In: Psychopharmacology. 1997 ; Vol. 133, No. 3. pp. 300-304.
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