Serial Galactose-Deficient IgA1 Levels in Children with IgA Nephropathy and Healthy Controls

John T. Sanders, M. Colleen Hastings, Zina Moldoveanu, Jan Novak, Bruce A. Julian, Zoran Bursac, Robert J. Wyatt

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Galactose-deficient IgA1 (Gd-IgA1) is a key pathogenic factor for IgA nephropathy (IgAN) and a potential biomarker for the disease. This study examined serial serum Gd-IgA1 levels over 1 year in 13 children with IgAN and 40 healthy children, to determine whether or not serum Gd-IgA1 levels changed over time. Subjects were younger than 18 years of age. Follow-up measurements were scheduled 6 and/or 12 months later. Analysis of variance and regression models for repeated measures were used to estimate group and time effects. Serum Gd-IgA1 level was higher in initial samples for IgAN patients compared to those of healthy children (P<0.0001). Serum Gd-IgA1 levels did not change over time for healthy controls but increased for IgAN patients (P=0.001). Serum Gd-IgA1 level was elevated for 9 children with IgAN at study entry and remained elevated. Two of the 4 IgAN patients with initially normal Gd-IgA1 levels had a subsequent elevated level. The persistent elevation of the serum Gd-IgA1 level in children with IgAN enhances its utility as a potential diagnostic test for IgAN.

Original languageEnglish (US)
Article number8210641
JournalInternational Journal of Nephrology
Volume2017
DOIs
StatePublished - Jan 1 2017

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Galactose
Immunoglobulin A
Serum
Routine Diagnostic Tests
Analysis of Variance

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Sanders, J. T., Hastings, M. C., Moldoveanu, Z., Novak, J., Julian, B. A., Bursac, Z., & Wyatt, R. J. (2017). Serial Galactose-Deficient IgA1 Levels in Children with IgA Nephropathy and Healthy Controls. International Journal of Nephrology, 2017, [8210641]. https://doi.org/10.1155/2017/8210641

Serial Galactose-Deficient IgA1 Levels in Children with IgA Nephropathy and Healthy Controls. / Sanders, John T.; Hastings, M. Colleen; Moldoveanu, Zina; Novak, Jan; Julian, Bruce A.; Bursac, Zoran; Wyatt, Robert J.

In: International Journal of Nephrology, Vol. 2017, 8210641, 01.01.2017.

Research output: Contribution to journalArticle

Sanders, John T. ; Hastings, M. Colleen ; Moldoveanu, Zina ; Novak, Jan ; Julian, Bruce A. ; Bursac, Zoran ; Wyatt, Robert J. / Serial Galactose-Deficient IgA1 Levels in Children with IgA Nephropathy and Healthy Controls. In: International Journal of Nephrology. 2017 ; Vol. 2017.
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