Serious hepatitis A: An analysis of patients hospitalized during an urban epidemic in the United States

Ira R. Willner, Mark D. Uhl, Scott Howard, Ernest Q. Williams, Caroline A. Riely, Bradford Waters

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Abstract

Background: Memphis and Shelby County, Tennessee, experienced an epidemic of hepatitis A in 1994 and 1995. More than 1700 cases were reported. Objective: To characterize the clinical features of patients hospitalized during a large urban epidemic of hepatitis A. Design: Retrospective chart review. Setting: 15 acute care hospitals in Shelby County, Tennessee. Patients: 256 patients hospitalized with acute hepatitis A. Measurements: Laboratory findings (such as prothrombin time and bilirubin level), complications, and mortality. Results: The median patient age was 26 years. Thirty-nine complications occurred in 35 patients. Twenty patients (8%) had extrahepatic complications, and 5 (2%) died. Patients 40 years of age and older were more likely to have serious complications, including death (P = 0.014). Sixty-seven patients (26%) presented with coagulopathy (prothrombin time ≤ 3 seconds prolonged). Fifty-four patients (21%) had a bilirubin level greater than 170 μmol/L (10 mg/dL). Conclusions: During this epidemic, hepatitis A caused serious illness and death. Complications were more frequent in patients 40 years of age and older, but young, healthy persons were also at risk for severe complications.

Original languageEnglish (US)
Pages (from-to)111-114
Number of pages4
JournalAnnals of internal medicine
Volume128
Issue number2
DOIs
StatePublished - Jan 15 1998

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Hepatitis A
Prothrombin Time
Bilirubin

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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Serious hepatitis A : An analysis of patients hospitalized during an urban epidemic in the United States. / Willner, Ira R.; Uhl, Mark D.; Howard, Scott; Williams, Ernest Q.; Riely, Caroline A.; Waters, Bradford.

In: Annals of internal medicine, Vol. 128, No. 2, 15.01.1998, p. 111-114.

Research output: Contribution to journalArticle

Willner, Ira R. ; Uhl, Mark D. ; Howard, Scott ; Williams, Ernest Q. ; Riely, Caroline A. ; Waters, Bradford. / Serious hepatitis A : An analysis of patients hospitalized during an urban epidemic in the United States. In: Annals of internal medicine. 1998 ; Vol. 128, No. 2. pp. 111-114.
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