Seroprevalence of measles antibodies and predictors for seropositivity among Chinese children

Xiaoqin Wang, Mei Ma, Zhaozhao Hui, Paul Terry, Yue Zhang, Rui Su, Mingxu Wang, Wei Gu, Ling Li

Research output: Contribution to journalArticle

Abstract

Background: Supplementary measles immunization has been implemented since 2010 throughout China, yet few studies have reported its effect in the northwest regions. Methods: A cross-sectional study was conducted among children aged 2 to 4 years old (n = 755) from February to September 2014 in 25 towns of Qian County, Shaanxi Province. Blood samples were analyzed for measles antibodies using enzyme-linked immunosorbent immunoglobulin G (IgG) assays. Socio-demographic factors were assessed by questionnaire. Data on vaccine dose were collected from town medical records. Univariate and logistic regression analyses were used to determine factors associated with measles antibody seropositivity. Results: Measles antibody seroprevalence was 91.13% (95% CI: 89.52-92.83) in our sample. Compared with children whose mother’s highest education was primary school, seroprevalence was higher in children whose maternal education was middle school (adjusted OR: 1.4, 95% CI: 0.7-2.8), high school (adjusted OR: 2.4, 95% CI: 1.3-7.7), and college/university (adjusted OR: 2.9, 95% CI: 1.2-9.3). Vaccine dose was positively associated with seropositivity. Conclusions: Measles seroprevalence is high in China and is associated with the mother’s education and vaccine dose.

Original languageEnglish (US)
Article number605
JournalInternational journal of environmental research and public health
Volume14
Issue number6
DOIs
StatePublished - Jun 6 2017

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Seroepidemiologic Studies
Measles
Antibodies
Vaccines
Mothers
Education
China
Immunosorbents
Medical Records
Immunization
Cross-Sectional Studies
Immunoglobulin G
Logistic Models
Regression Analysis
Demography
Enzymes

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Seroprevalence of measles antibodies and predictors for seropositivity among Chinese children. / Wang, Xiaoqin; Ma, Mei; Hui, Zhaozhao; Terry, Paul; Zhang, Yue; Su, Rui; Wang, Mingxu; Gu, Wei; Li, Ling.

In: International journal of environmental research and public health, Vol. 14, No. 6, 605, 06.06.2017.

Research output: Contribution to journalArticle

Wang, Xiaoqin ; Ma, Mei ; Hui, Zhaozhao ; Terry, Paul ; Zhang, Yue ; Su, Rui ; Wang, Mingxu ; Gu, Wei ; Li, Ling. / Seroprevalence of measles antibodies and predictors for seropositivity among Chinese children. In: International journal of environmental research and public health. 2017 ; Vol. 14, No. 6.
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abstract = "Background: Supplementary measles immunization has been implemented since 2010 throughout China, yet few studies have reported its effect in the northwest regions. Methods: A cross-sectional study was conducted among children aged 2 to 4 years old (n = 755) from February to September 2014 in 25 towns of Qian County, Shaanxi Province. Blood samples were analyzed for measles antibodies using enzyme-linked immunosorbent immunoglobulin G (IgG) assays. Socio-demographic factors were assessed by questionnaire. Data on vaccine dose were collected from town medical records. Univariate and logistic regression analyses were used to determine factors associated with measles antibody seropositivity. Results: Measles antibody seroprevalence was 91.13{\%} (95{\%} CI: 89.52-92.83) in our sample. Compared with children whose mother’s highest education was primary school, seroprevalence was higher in children whose maternal education was middle school (adjusted OR: 1.4, 95{\%} CI: 0.7-2.8), high school (adjusted OR: 2.4, 95{\%} CI: 1.3-7.7), and college/university (adjusted OR: 2.9, 95{\%} CI: 1.2-9.3). Vaccine dose was positively associated with seropositivity. Conclusions: Measles seroprevalence is high in China and is associated with the mother’s education and vaccine dose.",
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AU - Wang, Mingxu

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