Serum and alveolar procalcitonin concentrations during ventilator-associated pneumonia

Scott D. Hanes, G Christopher Wood, Britt Ritter, Bradley Boucher

Research output: Contribution to journalArticle

Abstract

Alveolar procalcitonin (PCT) concentrations may be a useful aid in the diagnosis of ventilator-associated pneumonia (VAP). To better characterize the potential utility of PCT in VAP, this study evaluated the relationship between serum and alveolar PCT concentrations in twelve critically ill trauma patients. Furthermore, the relationship between alveolar PCT concentrations, pneumonia development, and alveolar proinflammatory cytokine concentrations were analyzed. Serum and alveolar fluid were collected simultaneously within 48 hours of admission and at 4-7 days post-admission for analyte analysis. Overall, there was no significant correlation between serum and alveolar PCT concentrations. In six patients who developed VAP, alveolar PCT did not increase. Changes in alveolar PCT concentrations from baseline to follow-up were inversely related to changes in alveolar TNF-α and IL-1β. The results of this study suggest that PCT production is compartmentalized within the lung, similar to proinflammatory cytokines. More studies are needed to define the potential role of alveolar PCT in the diagnosis and pathogenesis of pneumonia.

Original languageEnglish (US)
Pages (from-to)59-72
Number of pages14
JournalJournal of Infectious Disease Pharmacotherapy
Volume6
Issue number2
DOIs
StatePublished - 2003

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Ventilator-Associated Pneumonia
Calcitonin
Serum
Pneumonia
Cytokines
Interleukin-1
Critical Illness
Lung

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Microbiology (medical)

Cite this

Serum and alveolar procalcitonin concentrations during ventilator-associated pneumonia. / Hanes, Scott D.; Wood, G Christopher; Ritter, Britt; Boucher, Bradley.

In: Journal of Infectious Disease Pharmacotherapy, Vol. 6, No. 2, 2003, p. 59-72.

Research output: Contribution to journalArticle

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