Serum ferritin

Deceptively simple or simply deceptive? Lessons learned from iron therapy in patients with chronic kidney disease

Csaba Kovesdy, Grace H. Lee, Kamyar Kalantar-Zadeh

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Iron is an essential micronutrient that is indispensable for erythropoesis. Correct assessment of iron stores is needed both for the diagnosis of iron deficiency and to direct iron replacement therapies. Serum ferritin is a commonly employed measure to assess iron stores, yet there are caveats that influence its accuracy as a diagnostic tool. While low ferritin levels are specific for iron deficiency, high levels can be the result of inflammation, liver disease, or malignancies and could be independent of iron stores. Optimal anemia management involves administration of adequate amounts of iron. The right dose of iron that allows optimal erythropoesis yet avoids oxidative stress is a matter of ongoing debate, especially when using imperfect diagnostic tools such as serum ferritin to direct therapy. Data from hemodialysis patients are presented to illustrate the challenges one faces when trying to achieve the best possible therapeutic benefit from iron-replacement therapy.

Original languageEnglish (US)
Pages (from-to)411-419
Number of pages9
JournalJournal of Pharmacy Practice
Volume21
Issue number6
DOIs
StatePublished - Dec 1 2008
Externally publishedYes

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Ferritins
Chronic Renal Insufficiency
Iron
Serum
Therapeutics
Micronutrients
Renal Dialysis
Liver Diseases
Anemia
Oxidative Stress
Inflammation

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)

Cite this

Serum ferritin : Deceptively simple or simply deceptive? Lessons learned from iron therapy in patients with chronic kidney disease. / Kovesdy, Csaba; Lee, Grace H.; Kalantar-Zadeh, Kamyar.

In: Journal of Pharmacy Practice, Vol. 21, No. 6, 01.12.2008, p. 411-419.

Research output: Contribution to journalReview article

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