Serum Ferritin Levels and Transferrin Saturation in Men with Prostate Cancer

Solo R. Kuvibidila, Tony Gauthier, Walter Rayford

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Abstract

Elevated body iron stores (serum ferritin >300 μg/L, transferrin saturation TS >50%) are associated with increased risk of liver and lung cancers. To determine whether such association also exists for prostate cancer (PC), we measured serum ferritin, serum iron, total iron-binding capacity (TIBC), and TS in serum samples from 34 men with newly diagnosed, untreated PC and 84 healthy men, ranging in age from 49-78 years. In contrast with other malignancies, men with PC had significantly lower mean concentrations of serum ferritin (156 μg/L) and TS (24.35%) than those without PC (ferritin, 245 μg/L; TS, 31.98%) (p<0.05). The 95% confidence intervals for ferritin were 109-203 μg/L and 205-286 μg/L, and those for TS were 20.29-28.4% and 28.35-35.61% for men with and without PC, respectively. Significant differences were observed between both groups in the distribution of serum ferritin (<100, 101-300, >300 μg/L) and TS (<16, 16-50, >50%) (p<0.05). A lower percentage of cases than of controls had serum ferritin (17.6% versus 29.8%) and TS (5.9% versus 14.7%) above normal. These differences persisted when the analysis was limited to African-American men (31 cases and 52 controls). Data suggest that elevated body iron stores are less common in men with PC compared to those without PC.

Original languageEnglish (US)
Pages (from-to)641-649
Number of pages9
JournalJournal of the National Medical Association
Volume96
Issue number5
StatePublished - May 1 2004

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Transferrin
Ferritins
Prostatic Neoplasms
Iron
Serum
Liver Neoplasms
African Americans
Lung Neoplasms
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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Serum Ferritin Levels and Transferrin Saturation in Men with Prostate Cancer. / Kuvibidila, Solo R.; Gauthier, Tony; Rayford, Walter.

In: Journal of the National Medical Association, Vol. 96, No. 5, 01.05.2004, p. 641-649.

Research output: Contribution to journalArticle

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abstract = "Elevated body iron stores (serum ferritin >300 μg/L, transferrin saturation TS >50{\%}) are associated with increased risk of liver and lung cancers. To determine whether such association also exists for prostate cancer (PC), we measured serum ferritin, serum iron, total iron-binding capacity (TIBC), and TS in serum samples from 34 men with newly diagnosed, untreated PC and 84 healthy men, ranging in age from 49-78 years. In contrast with other malignancies, men with PC had significantly lower mean concentrations of serum ferritin (156 μg/L) and TS (24.35{\%}) than those without PC (ferritin, 245 μg/L; TS, 31.98{\%}) (p<0.05). The 95{\%} confidence intervals for ferritin were 109-203 μg/L and 205-286 μg/L, and those for TS were 20.29-28.4{\%} and 28.35-35.61{\%} for men with and without PC, respectively. Significant differences were observed between both groups in the distribution of serum ferritin (<100, 101-300, >300 μg/L) and TS (<16, 16-50, >50{\%}) (p<0.05). A lower percentage of cases than of controls had serum ferritin (17.6{\%} versus 29.8{\%}) and TS (5.9{\%} versus 14.7{\%}) above normal. These differences persisted when the analysis was limited to African-American men (31 cases and 52 controls). Data suggest that elevated body iron stores are less common in men with PC compared to those without PC.",
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