Serum transfer of collagen‐induced arthritis.II. Identification and Localization of Autoantibody to Type II Collagen in Donor and Recipient Rats

John Stuart, Koichi Tomoda, Tai June O. Yo Md, Alexander S. Townes, Andrew Kang

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Collagen‐induced arthritis can be transferred from immunized arthritic rats to unimmunized recipients by intravenous injection of an immunoglobulin concentrate of sera. This study identifies antibodies in the transfer concentrate which localize to the articular surface of cartilage in joints of recipients. Immunoglobulin can also be demonstrated in the same location in arthritic joints from rats after immunization. Antibody capable of transferring arthritis is present in donor rats over a period of at least 3 weeks and can be absorbed using homologous type II collagen. In addition, antitype II collagen antibodies can be eluted from arthritic joints of rats with early disease.

Original languageEnglish (US)
Pages (from-to)1237-1244
Number of pages8
JournalArthritis & Rheumatism
Volume26
Issue number10
DOIs
StatePublished - Jan 1 1983

Fingerprint

Collagen Type II
Autoantibodies
Arthritis
Serum
Joints
Antibodies
Intravenous Immunoglobulins
Articular Cartilage
Intravenous Injections
Immunoglobulins
Immunization
Collagen

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

Cite this

Serum transfer of collagen‐induced arthritis.II. Identification and Localization of Autoantibody to Type II Collagen in Donor and Recipient Rats. / Stuart, John; Tomoda, Koichi; Yo Md, Tai June O.; Townes, Alexander S.; Kang, Andrew.

In: Arthritis & Rheumatism, Vol. 26, No. 10, 01.01.1983, p. 1237-1244.

Research output: Contribution to journalArticle

Stuart, John ; Tomoda, Koichi ; Yo Md, Tai June O. ; Townes, Alexander S. ; Kang, Andrew. / Serum transfer of collagen‐induced arthritis.II. Identification and Localization of Autoantibody to Type II Collagen in Donor and Recipient Rats. In: Arthritis & Rheumatism. 1983 ; Vol. 26, No. 10. pp. 1237-1244.
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