Serum Vitamin D concentrations in baboons (Papio spp.) during pregnancy and obesity

Natalia E. Schlabritz-Loutsevitch, Anthony G. Comuzzie, Michael M. Mahaney, Gene B. Hubbard, Edward J. Dick, Mehmet Kocak, Sonali Gupta, Maira Carrillo, Mauro Schenone, Arnold Postlethwaite, Andrzej Slominski

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Obesity is associated with Vitamin D deficiency, which can lead to serious problems during pregnancy. However, the mechanisms of the deficiency and guidelines for Vitamin D supplementation during pregnancy are not established yet, and variations in environmental exposures combined with the difficulties of performing research in pregnant women are obstacles in the evaluation of Vitamin D metabolism. Baboons (Papio spp.) are an excellent, well-established model for reproductive research and represent a unique opportunity to study Vitamin D metabolism in a controlled environment. This study used secondary data and specimen analysis as well as a novel experimental design to evaluate pregnant and nonpregnant baboons that were or were not exposed to sunlight while they were obese and after weight reduction. Daily D3 intake was 71% higher in nonpregnant obese baboons than in their nonobese counterparts, but serum Vitamin D concentrations did not differ between these populations. In addition, serum 25-hydroxyVitamin D concentrations correlated negatively with the obesity index. This report is the first to show the effect of obesity and pregnancy on Vitamin D concentrations in a NHP population. These data underline the importance of adequate Vitamin D supplementation in obese animals.

Original languageEnglish (US)
Pages (from-to)137-142
Number of pages6
JournalComparative Medicine
Volume66
Issue number2
StatePublished - Apr 1 2016

Fingerprint

Papio
vitamin D
Vitamin D
obesity
Obesity
pregnancy
Pregnancy
Serum
Vitamin D Deficiency
Metabolism
Controlled Environment
Sunlight
Environmental Exposure
vitamin D deficiency
metabolism
Research
Population
pregnant women
Weight Loss
Pregnant Women

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

Cite this

Schlabritz-Loutsevitch, N. E., Comuzzie, A. G., Mahaney, M. M., Hubbard, G. B., Dick, E. J., Kocak, M., ... Slominski, A. (2016). Serum Vitamin D concentrations in baboons (Papio spp.) during pregnancy and obesity. Comparative Medicine, 66(2), 137-142.

Serum Vitamin D concentrations in baboons (Papio spp.) during pregnancy and obesity. / Schlabritz-Loutsevitch, Natalia E.; Comuzzie, Anthony G.; Mahaney, Michael M.; Hubbard, Gene B.; Dick, Edward J.; Kocak, Mehmet; Gupta, Sonali; Carrillo, Maira; Schenone, Mauro; Postlethwaite, Arnold; Slominski, Andrzej.

In: Comparative Medicine, Vol. 66, No. 2, 01.04.2016, p. 137-142.

Research output: Contribution to journalArticle

Schlabritz-Loutsevitch, NE, Comuzzie, AG, Mahaney, MM, Hubbard, GB, Dick, EJ, Kocak, M, Gupta, S, Carrillo, M, Schenone, M, Postlethwaite, A & Slominski, A 2016, 'Serum Vitamin D concentrations in baboons (Papio spp.) during pregnancy and obesity', Comparative Medicine, vol. 66, no. 2, pp. 137-142.
Schlabritz-Loutsevitch NE, Comuzzie AG, Mahaney MM, Hubbard GB, Dick EJ, Kocak M et al. Serum Vitamin D concentrations in baboons (Papio spp.) during pregnancy and obesity. Comparative Medicine. 2016 Apr 1;66(2):137-142.
Schlabritz-Loutsevitch, Natalia E. ; Comuzzie, Anthony G. ; Mahaney, Michael M. ; Hubbard, Gene B. ; Dick, Edward J. ; Kocak, Mehmet ; Gupta, Sonali ; Carrillo, Maira ; Schenone, Mauro ; Postlethwaite, Arnold ; Slominski, Andrzej. / Serum Vitamin D concentrations in baboons (Papio spp.) during pregnancy and obesity. In: Comparative Medicine. 2016 ; Vol. 66, No. 2. pp. 137-142.
@article{b8e6782180be497fb7790c93204ea762,
title = "Serum Vitamin D concentrations in baboons (Papio spp.) during pregnancy and obesity",
abstract = "Obesity is associated with Vitamin D deficiency, which can lead to serious problems during pregnancy. However, the mechanisms of the deficiency and guidelines for Vitamin D supplementation during pregnancy are not established yet, and variations in environmental exposures combined with the difficulties of performing research in pregnant women are obstacles in the evaluation of Vitamin D metabolism. Baboons (Papio spp.) are an excellent, well-established model for reproductive research and represent a unique opportunity to study Vitamin D metabolism in a controlled environment. This study used secondary data and specimen analysis as well as a novel experimental design to evaluate pregnant and nonpregnant baboons that were or were not exposed to sunlight while they were obese and after weight reduction. Daily D3 intake was 71{\%} higher in nonpregnant obese baboons than in their nonobese counterparts, but serum Vitamin D concentrations did not differ between these populations. In addition, serum 25-hydroxyVitamin D concentrations correlated negatively with the obesity index. This report is the first to show the effect of obesity and pregnancy on Vitamin D concentrations in a NHP population. These data underline the importance of adequate Vitamin D supplementation in obese animals.",
author = "Schlabritz-Loutsevitch, {Natalia E.} and Comuzzie, {Anthony G.} and Mahaney, {Michael M.} and Hubbard, {Gene B.} and Dick, {Edward J.} and Mehmet Kocak and Sonali Gupta and Maira Carrillo and Mauro Schenone and Arnold Postlethwaite and Andrzej Slominski",
year = "2016",
month = "4",
day = "1",
language = "English (US)",
volume = "66",
pages = "137--142",
journal = "Comparative Medicine",
issn = "1532-0820",
publisher = "American Association for Laboratory Animal Science",
number = "2",

}

TY - JOUR

T1 - Serum Vitamin D concentrations in baboons (Papio spp.) during pregnancy and obesity

AU - Schlabritz-Loutsevitch, Natalia E.

AU - Comuzzie, Anthony G.

AU - Mahaney, Michael M.

AU - Hubbard, Gene B.

AU - Dick, Edward J.

AU - Kocak, Mehmet

AU - Gupta, Sonali

AU - Carrillo, Maira

AU - Schenone, Mauro

AU - Postlethwaite, Arnold

AU - Slominski, Andrzej

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Obesity is associated with Vitamin D deficiency, which can lead to serious problems during pregnancy. However, the mechanisms of the deficiency and guidelines for Vitamin D supplementation during pregnancy are not established yet, and variations in environmental exposures combined with the difficulties of performing research in pregnant women are obstacles in the evaluation of Vitamin D metabolism. Baboons (Papio spp.) are an excellent, well-established model for reproductive research and represent a unique opportunity to study Vitamin D metabolism in a controlled environment. This study used secondary data and specimen analysis as well as a novel experimental design to evaluate pregnant and nonpregnant baboons that were or were not exposed to sunlight while they were obese and after weight reduction. Daily D3 intake was 71% higher in nonpregnant obese baboons than in their nonobese counterparts, but serum Vitamin D concentrations did not differ between these populations. In addition, serum 25-hydroxyVitamin D concentrations correlated negatively with the obesity index. This report is the first to show the effect of obesity and pregnancy on Vitamin D concentrations in a NHP population. These data underline the importance of adequate Vitamin D supplementation in obese animals.

AB - Obesity is associated with Vitamin D deficiency, which can lead to serious problems during pregnancy. However, the mechanisms of the deficiency and guidelines for Vitamin D supplementation during pregnancy are not established yet, and variations in environmental exposures combined with the difficulties of performing research in pregnant women are obstacles in the evaluation of Vitamin D metabolism. Baboons (Papio spp.) are an excellent, well-established model for reproductive research and represent a unique opportunity to study Vitamin D metabolism in a controlled environment. This study used secondary data and specimen analysis as well as a novel experimental design to evaluate pregnant and nonpregnant baboons that were or were not exposed to sunlight while they were obese and after weight reduction. Daily D3 intake was 71% higher in nonpregnant obese baboons than in their nonobese counterparts, but serum Vitamin D concentrations did not differ between these populations. In addition, serum 25-hydroxyVitamin D concentrations correlated negatively with the obesity index. This report is the first to show the effect of obesity and pregnancy on Vitamin D concentrations in a NHP population. These data underline the importance of adequate Vitamin D supplementation in obese animals.

UR - http://www.scopus.com/inward/record.url?scp=84963935999&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84963935999&partnerID=8YFLogxK

M3 - Article

VL - 66

SP - 137

EP - 142

JO - Comparative Medicine

JF - Comparative Medicine

SN - 1532-0820

IS - 2

ER -