Severe hypercholesterolemia mediated by lipoprotein X in a pediatric patient with chronic graft-versus-host disease of the liver

Hanaa Zidan, Stanley Lo, Donald Wiebe, Julie Talano, Ramin Alemzadeh

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We describe a case of extreme hypercholesterolemia, mediated by lipoprotein X, in a 1 2-year-old Caucasian female who underwent an unrelated allogenic bone marrow transplant for relapsed acute myelocytic leukemia (AML). Her post-transplant course was complicated by severe chronic graft-versus-host disease (GVHD) of the liver. Previously normal serum cholesterol and triglycerides rose to 1,122 mg/dl (29.0 mmol/L) and 1,100 mg/dl (12.4 mmol/L), respectively. Serum cholesterol appeared to be dominantly carried by lipoprotein X. Intra-hepatic cholestasis leading to reflux of bile lipoproteins into the blood stream and subsequent formation of lipoprotein X appears to be the mechanism underlying this phenomenon.

Original languageEnglish (US)
Pages (from-to)1280-1281
Number of pages2
JournalPediatric Blood and Cancer
Volume50
Issue number6
DOIs
StatePublished - Jun 1 2008
Externally publishedYes

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Lipoprotein-X
Graft vs Host Disease
Hypercholesterolemia
Pediatrics
Liver
Cholesterol
Bile Reflux
Transplants
Cholestasis
Serum
Acute Myeloid Leukemia
Lipoproteins
Triglycerides
Bone Marrow

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Cite this

Severe hypercholesterolemia mediated by lipoprotein X in a pediatric patient with chronic graft-versus-host disease of the liver. / Zidan, Hanaa; Lo, Stanley; Wiebe, Donald; Talano, Julie; Alemzadeh, Ramin.

In: Pediatric Blood and Cancer, Vol. 50, No. 6, 01.06.2008, p. 1280-1281.

Research output: Contribution to journalArticle

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