Severe neutropenia in patients with chronic hepatitis C

A benign condition

Vivien Sheehan, Alva Weir, Bradford Waters

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background/Aims: Patients with chronic hepatitis C virus (HCV) infection may develop neutropenia, which can delay or prevent treatment. Severe neutropenia, absolute neutrophil counts (ANC) ≤0.500 × 10 9/l, is a rare finding, with only two isolated reports published in the literature. The aim of this study was to evaluate the incidence and natural history of severe neutropenia in hepatitis C patients. Methods: The records of 685 patients with active HCV were reviewed to identify those with severe neutropenia. The laboratory parameters and clinical history data of patients with severe neutropenia were then compared to a cohort of patients with HCV patients who had the more common minor neutropenia (ANC = 1.000-1.500 10 9/l). Results: There was no significant difference in race, MELD (Model for End Stage Liver Disease) scores, portal hypertension, splenomegaly, viral load, viral type, or hemoglobin or platelet levels. Neither group suffered serious systemic infections. Conclusions: Severe neutropenia in HCV patients is underreported and not associated with serious HCV complications such as elevated MELD score or cirrhosis. Serious infection is rare and patients respond well to granulocyte colony-stimulating factor. Severely neutropenic patients with HCV appear to have a benign course and may be candidates for antiviral therapy.

Original languageEnglish (US)
Pages (from-to)96-100
Number of pages5
JournalActa Haematologica
Volume129
Issue number2
DOIs
StatePublished - Jan 1 2013

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Chronic Hepatitis C
Neutropenia
Hepacivirus
End Stage Liver Disease
Neutrophils
Splenomegaly
Portal Hypertension
Granulocyte Colony-Stimulating Factor
Virus Diseases
Hepatitis C
Infection
Viral Load
Liver Cirrhosis
Antiviral Agents
Hemoglobins
Blood Platelets
Incidence
Therapeutics

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Severe neutropenia in patients with chronic hepatitis C : A benign condition. / Sheehan, Vivien; Weir, Alva; Waters, Bradford.

In: Acta Haematologica, Vol. 129, No. 2, 01.01.2013, p. 96-100.

Research output: Contribution to journalArticle

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