Severe sepsis and septic shock in patients with pre-existing non-cardiac pulmonary hypertension: Contemporary management and outcomes

Mykola V. Tsapenko, Vitaly Herasevich, Girish K. Mour, Arseniy Tsapenko, Thomas B O Comfere, Sunil V. Mankad, Rodrigo Cartin-Ceba, Ognjen Gajic, Robert C. Albright

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Objective: To review treatment and outcomes of septic shock in patients with pulmonary hypertension (PH) managed at a tertiary care institution. Design, setting and patients: We identified consecutive patients with non-cardiac PH (non-Group 2 in the World Health Organization classification) who were treated for septic shock in four intensive care units at a tertiary care institution between July 2004 and July 2007. Patients with a left ventricular ejection fraction < 50%, Diastolic dysfunction, pericardial effusion or significant valve disease were excluded. Descriptive statistics were used to analyse the data. Main outcome measures: Hospital mortality, duration of vasopressor and ventilatory support, length of hospital and ICU stay. Results: The final group for analysis comprised 82 patients. The major causes of PH were chronic obstructive pulmonary disease, interstitial lung disease and portopulmonary hypertension. PH was mild in 46 patients (56%), moderate in 21 (26%) and severe in 15 (18%). Vasopressor treatment was initiated in 69 patients (84%) within the first 48 hours: noradrenaline was most commonly used (53 patients, 65%), and 51 patients (62%) were treated with more than one agent. Sixty-seven patients (82%) were mechanically ventilated, and 33 (40%) required renal replacement therapy. Forty-three patients (52%) survived to hospital discharge; 23 (28%) remained alive at 1 year. Hospital mortality increased with severity of PH: 28% in mild, 67% in moderate and 80% in severe PH. Non-survivors were more likely to have plateau pressures beyond 30 cm H2O while mechanically ventilated within the first 48 hours in the ICU (56% v 29%, P = 0.03), to develop atrial fibrillation (AF) (46% v 12%, P < 0.001), and to require longer vasopressor support (mean, 5.3 v 2.6 days, P = 0.003). In a multivariate logistic regression analysis, severity of PH (odds ratio [OR], 1.55; 95% CI, 1.04-2.46; P=0.04), new-onset AF (OR, 6.51; 95% CI, 2.24-22.07; P<0.001) and longer duration of vasopressor support (OR, 1.15; 95% CI, 1.03-1.34; P = 0.04) were associated with increased hospital mortality. Conclusions: The severity of PH, new-onset AF, and longer vasopressor support were associated with poor outcomes in patients with PH who developed severe sepsis and septic shock.

Original languageEnglish (US)
Pages (from-to)103-109
Number of pages7
JournalCritical Care and Resuscitation
Volume15
Issue number2
StatePublished - Dec 3 2013
Externally publishedYes

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Septic Shock
Pulmonary Hypertension
Sepsis
Hospital Mortality
Atrial Fibrillation
Odds Ratio
Tertiary Healthcare
Renal Replacement Therapy
Pericardial Effusion
Interstitial Lung Diseases
Stroke Volume
Chronic Obstructive Pulmonary Disease
Intensive Care Units
Length of Stay
Norepinephrine
Logistic Models
Regression Analysis
Outcome Assessment (Health Care)
Hypertension
Pressure

All Science Journal Classification (ASJC) codes

  • Emergency Medicine
  • Medicine(all)
  • Critical Care and Intensive Care Medicine
  • Anesthesiology and Pain Medicine

Cite this

Tsapenko, M. V., Herasevich, V., Mour, G. K., Tsapenko, A., Comfere, T. B. O., Mankad, S. V., ... Albright, R. C. (2013). Severe sepsis and septic shock in patients with pre-existing non-cardiac pulmonary hypertension: Contemporary management and outcomes. Critical Care and Resuscitation, 15(2), 103-109.

Severe sepsis and septic shock in patients with pre-existing non-cardiac pulmonary hypertension : Contemporary management and outcomes. / Tsapenko, Mykola V.; Herasevich, Vitaly; Mour, Girish K.; Tsapenko, Arseniy; Comfere, Thomas B O; Mankad, Sunil V.; Cartin-Ceba, Rodrigo; Gajic, Ognjen; Albright, Robert C.

In: Critical Care and Resuscitation, Vol. 15, No. 2, 03.12.2013, p. 103-109.

Research output: Contribution to journalReview article

Tsapenko, MV, Herasevich, V, Mour, GK, Tsapenko, A, Comfere, TBO, Mankad, SV, Cartin-Ceba, R, Gajic, O & Albright, RC 2013, 'Severe sepsis and septic shock in patients with pre-existing non-cardiac pulmonary hypertension: Contemporary management and outcomes', Critical Care and Resuscitation, vol. 15, no. 2, pp. 103-109.
Tsapenko, Mykola V. ; Herasevich, Vitaly ; Mour, Girish K. ; Tsapenko, Arseniy ; Comfere, Thomas B O ; Mankad, Sunil V. ; Cartin-Ceba, Rodrigo ; Gajic, Ognjen ; Albright, Robert C. / Severe sepsis and septic shock in patients with pre-existing non-cardiac pulmonary hypertension : Contemporary management and outcomes. In: Critical Care and Resuscitation. 2013 ; Vol. 15, No. 2. pp. 103-109.
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abstract = "Objective: To review treatment and outcomes of septic shock in patients with pulmonary hypertension (PH) managed at a tertiary care institution. Design, setting and patients: We identified consecutive patients with non-cardiac PH (non-Group 2 in the World Health Organization classification) who were treated for septic shock in four intensive care units at a tertiary care institution between July 2004 and July 2007. Patients with a left ventricular ejection fraction < 50{\%}, Diastolic dysfunction, pericardial effusion or significant valve disease were excluded. Descriptive statistics were used to analyse the data. Main outcome measures: Hospital mortality, duration of vasopressor and ventilatory support, length of hospital and ICU stay. Results: The final group for analysis comprised 82 patients. The major causes of PH were chronic obstructive pulmonary disease, interstitial lung disease and portopulmonary hypertension. PH was mild in 46 patients (56{\%}), moderate in 21 (26{\%}) and severe in 15 (18{\%}). Vasopressor treatment was initiated in 69 patients (84{\%}) within the first 48 hours: noradrenaline was most commonly used (53 patients, 65{\%}), and 51 patients (62{\%}) were treated with more than one agent. Sixty-seven patients (82{\%}) were mechanically ventilated, and 33 (40{\%}) required renal replacement therapy. Forty-three patients (52{\%}) survived to hospital discharge; 23 (28{\%}) remained alive at 1 year. Hospital mortality increased with severity of PH: 28{\%} in mild, 67{\%} in moderate and 80{\%} in severe PH. Non-survivors were more likely to have plateau pressures beyond 30 cm H2O while mechanically ventilated within the first 48 hours in the ICU (56{\%} v 29{\%}, P = 0.03), to develop atrial fibrillation (AF) (46{\%} v 12{\%}, P < 0.001), and to require longer vasopressor support (mean, 5.3 v 2.6 days, P = 0.003). In a multivariate logistic regression analysis, severity of PH (odds ratio [OR], 1.55; 95{\%} CI, 1.04-2.46; P=0.04), new-onset AF (OR, 6.51; 95{\%} CI, 2.24-22.07; P<0.001) and longer duration of vasopressor support (OR, 1.15; 95{\%} CI, 1.03-1.34; P = 0.04) were associated with increased hospital mortality. Conclusions: The severity of PH, new-onset AF, and longer vasopressor support were associated with poor outcomes in patients with PH who developed severe sepsis and septic shock.",
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T1 - Severe sepsis and septic shock in patients with pre-existing non-cardiac pulmonary hypertension

T2 - Contemporary management and outcomes

AU - Tsapenko, Mykola V.

AU - Herasevich, Vitaly

AU - Mour, Girish K.

AU - Tsapenko, Arseniy

AU - Comfere, Thomas B O

AU - Mankad, Sunil V.

AU - Cartin-Ceba, Rodrigo

AU - Gajic, Ognjen

AU - Albright, Robert C.

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N2 - Objective: To review treatment and outcomes of septic shock in patients with pulmonary hypertension (PH) managed at a tertiary care institution. Design, setting and patients: We identified consecutive patients with non-cardiac PH (non-Group 2 in the World Health Organization classification) who were treated for septic shock in four intensive care units at a tertiary care institution between July 2004 and July 2007. Patients with a left ventricular ejection fraction < 50%, Diastolic dysfunction, pericardial effusion or significant valve disease were excluded. Descriptive statistics were used to analyse the data. Main outcome measures: Hospital mortality, duration of vasopressor and ventilatory support, length of hospital and ICU stay. Results: The final group for analysis comprised 82 patients. The major causes of PH were chronic obstructive pulmonary disease, interstitial lung disease and portopulmonary hypertension. PH was mild in 46 patients (56%), moderate in 21 (26%) and severe in 15 (18%). Vasopressor treatment was initiated in 69 patients (84%) within the first 48 hours: noradrenaline was most commonly used (53 patients, 65%), and 51 patients (62%) were treated with more than one agent. Sixty-seven patients (82%) were mechanically ventilated, and 33 (40%) required renal replacement therapy. Forty-three patients (52%) survived to hospital discharge; 23 (28%) remained alive at 1 year. Hospital mortality increased with severity of PH: 28% in mild, 67% in moderate and 80% in severe PH. Non-survivors were more likely to have plateau pressures beyond 30 cm H2O while mechanically ventilated within the first 48 hours in the ICU (56% v 29%, P = 0.03), to develop atrial fibrillation (AF) (46% v 12%, P < 0.001), and to require longer vasopressor support (mean, 5.3 v 2.6 days, P = 0.003). In a multivariate logistic regression analysis, severity of PH (odds ratio [OR], 1.55; 95% CI, 1.04-2.46; P=0.04), new-onset AF (OR, 6.51; 95% CI, 2.24-22.07; P<0.001) and longer duration of vasopressor support (OR, 1.15; 95% CI, 1.03-1.34; P = 0.04) were associated with increased hospital mortality. Conclusions: The severity of PH, new-onset AF, and longer vasopressor support were associated with poor outcomes in patients with PH who developed severe sepsis and septic shock.

AB - Objective: To review treatment and outcomes of septic shock in patients with pulmonary hypertension (PH) managed at a tertiary care institution. Design, setting and patients: We identified consecutive patients with non-cardiac PH (non-Group 2 in the World Health Organization classification) who were treated for septic shock in four intensive care units at a tertiary care institution between July 2004 and July 2007. Patients with a left ventricular ejection fraction < 50%, Diastolic dysfunction, pericardial effusion or significant valve disease were excluded. Descriptive statistics were used to analyse the data. Main outcome measures: Hospital mortality, duration of vasopressor and ventilatory support, length of hospital and ICU stay. Results: The final group for analysis comprised 82 patients. The major causes of PH were chronic obstructive pulmonary disease, interstitial lung disease and portopulmonary hypertension. PH was mild in 46 patients (56%), moderate in 21 (26%) and severe in 15 (18%). Vasopressor treatment was initiated in 69 patients (84%) within the first 48 hours: noradrenaline was most commonly used (53 patients, 65%), and 51 patients (62%) were treated with more than one agent. Sixty-seven patients (82%) were mechanically ventilated, and 33 (40%) required renal replacement therapy. Forty-three patients (52%) survived to hospital discharge; 23 (28%) remained alive at 1 year. Hospital mortality increased with severity of PH: 28% in mild, 67% in moderate and 80% in severe PH. Non-survivors were more likely to have plateau pressures beyond 30 cm H2O while mechanically ventilated within the first 48 hours in the ICU (56% v 29%, P = 0.03), to develop atrial fibrillation (AF) (46% v 12%, P < 0.001), and to require longer vasopressor support (mean, 5.3 v 2.6 days, P = 0.003). In a multivariate logistic regression analysis, severity of PH (odds ratio [OR], 1.55; 95% CI, 1.04-2.46; P=0.04), new-onset AF (OR, 6.51; 95% CI, 2.24-22.07; P<0.001) and longer duration of vasopressor support (OR, 1.15; 95% CI, 1.03-1.34; P = 0.04) were associated with increased hospital mortality. Conclusions: The severity of PH, new-onset AF, and longer vasopressor support were associated with poor outcomes in patients with PH who developed severe sepsis and septic shock.

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