Sex hormones binding globulin levels across the adult lifespan in women - The role of body mass index and fasting insulin

M. Maggio, F. Lauretani, S. Basaria, G. P. Ceda, S. Bandinelli, E. Metter, A. J. Bos, C. Ruggiero, G. Ceresini, G. Paolisso, A. Artoni, G. Valenti, J. M. Guralnik, L. Ferrucci

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

SHBG is a major carrier of androgens. In men, SHBG levels increase with age, while in women data are scant. There is evidence that body mass index (BMI) and fasting insulin influence SHBG concentration. Since low SHBG levels are predictors of insulin resistance and diabetes, understanding the relationship of SHBG with age, insulin, and BMI is important to gain insight into the role of SHBG as a cardiovascular risk factor in women. Differences in SHBG across adult life span and their relationship with insulin and BMI were evaluated in a representative cohort of 616 Italian women free of diabetes and not on hormone replacement therapy enrolled in the InCHIANTI Study. The relationship of SHBG with age, BMI, and fasting insulin levels was analyzed using linear regression and by loess smoother. Serum SHBG levels showed a U-shaped trajectory with age, declining from the 2nd to the 6th decade of life and increasing after the 6th decade (p<0.0001). Age-related trends for BMI and fasting insulin mirrored the trend observed for SHBG. After adjusting for fasting insulin, the relationship between log (SHBG) and age square was attenuated (β coefficient from 0.00044 to 0.00039) and was further reduced after adjustment for BMI (from 0.00039 to 0.00028). SHBG levels show an age-related U-shaped trajectory. These changes mirror the age-related changes in BMI and fasting insulin, suggesting that BMI and insulin negatively influence SHBG concentration.

Original languageEnglish (US)
Pages (from-to)597-601
Number of pages5
JournalJournal of Endocrinological Investigation
Volume31
Issue number7
DOIs
StatePublished - Jan 1 2008

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Sex Hormone-Binding Globulin
Fasting
Body Mass Index
Insulin
Hormone Replacement Therapy
Androgens
Insulin Resistance
Linear Models
Serum

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Sex hormones binding globulin levels across the adult lifespan in women - The role of body mass index and fasting insulin. / Maggio, M.; Lauretani, F.; Basaria, S.; Ceda, G. P.; Bandinelli, S.; Metter, E.; Bos, A. J.; Ruggiero, C.; Ceresini, G.; Paolisso, G.; Artoni, A.; Valenti, G.; Guralnik, J. M.; Ferrucci, L.

In: Journal of Endocrinological Investigation, Vol. 31, No. 7, 01.01.2008, p. 597-601.

Research output: Contribution to journalArticle

Maggio, M, Lauretani, F, Basaria, S, Ceda, GP, Bandinelli, S, Metter, E, Bos, AJ, Ruggiero, C, Ceresini, G, Paolisso, G, Artoni, A, Valenti, G, Guralnik, JM & Ferrucci, L 2008, 'Sex hormones binding globulin levels across the adult lifespan in women - The role of body mass index and fasting insulin', Journal of Endocrinological Investigation, vol. 31, no. 7, pp. 597-601. https://doi.org/10.1007/BF03345608
Maggio, M. ; Lauretani, F. ; Basaria, S. ; Ceda, G. P. ; Bandinelli, S. ; Metter, E. ; Bos, A. J. ; Ruggiero, C. ; Ceresini, G. ; Paolisso, G. ; Artoni, A. ; Valenti, G. ; Guralnik, J. M. ; Ferrucci, L. / Sex hormones binding globulin levels across the adult lifespan in women - The role of body mass index and fasting insulin. In: Journal of Endocrinological Investigation. 2008 ; Vol. 31, No. 7. pp. 597-601.
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AU - Paolisso, G.

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