Sex, prescribing practices and guideline recommended, blood pressure, and LDL cholesterol targets at baseline in the BARI 2D trial

Michelle F. Magee, Jacqueline E. Tamis-Holland, Jiang Lu, Vera A. Bittner, Maria Mori Brooks, Neuza Lopes, Alice K. Jacobs, Katherine M. Detre, Sheryl F. Kelsey, Trevor J. Orchard, Stephen B. Thomas, Kim Sutton Tyrrell, Jamal S. Rana, Frani Averbach, Joan M. MacGregor, Scott M. O'Neal, Kathleen Pitluga, Veronica Sansing, Mary Tranchine, Sharon W. Crow & 391 others Marianne Bertolet, Regina Hardison, Kevin Kip, Manuel Lombardero, Sue Janiszewski, Darina Protivnak, Sarah Reiser, Stephen Barton, Ping Guo, Yulia Kushner, Jeffrey P. Martin, Christopher Kania, Michael Kania, Jeffrey O'Donnell, Rae Ann Maxwell, Robert L. Frye, Suzanne Goldberg, Yves Rosenberg, Patrice Desvigne-Nickens, Abby Ershow, David Gordon, Dina Paltoo, Teresa L.Z. Jones, Whady Hueb, José Ramires, Bernardo Léo Wajchenberg, Eulogio E. Martinez, Sergio A. Oliveira, Expedito E. Ribeiro, Marcos Perin, Roberto Betti, Leonard Schwartz, George Steiner, Alan Barolet, Yolanda Groenewoud, Lisa Mighton, Kathy Camelon, Robert O'Rourke, Janet Blodgett, Edward Sako, Judith Nicastro, Robin Prescott, Charanjit Rihal, Frank Kennedy, Gregory Barsness, Amanda Basu, Alfredo Clavell, Robert Frye, David R. Holmes, Amir Lerman, Charles Mullaney, Guy Reeder, Robert Rizza, Hartzell Schaff, Steven Smith, Virend Somers, Thoralf Sundt, Henry Ting, R. Scott Wright, Pam Helgemoe, Diane Lesmeister, Deborah Rolbiecki, Luis Lepe-Montoya, Jorge Escobedo, Rafael Barraza, Rubén Baleón, Arturo Campos, Paula García, Carlos Lezama, Carlos Miramontes, Salvador Ocampo, Joaquí Peñafiel, Aquiles Valdespino, Raúl Verdín, Hé Albarrán, Fernando Ayala, Eduardo Chávez, Hé Murillo, Luisa Virginia Buitrón, Beatriz Rico-Verdin, Fabiola Angulo, Dale Adler, Austin Arthur Halle, Faramarz Ismail-Beigi, Suvinay Paranjape, Stacey Mazzurco, Karen Ridley, K Ramanathan, Solomon Solomon, Barry Wall, Darryl Weinman, Tammy Touchstone, Lillie Douglas, Martial Bourassa, Jean Claude Tardif, Jean Louis Chiasson, Marc Andre Lavoie, Rémi Rabasa-Lhoret, Hélène Langelier, Suzy Foucher, Johanne Trudel, Scott Monrad, Vankeepuram Srinivas, Joel Zonszein, Jill Crandall, Helena Duffy, Eugen Vartolomei, Spencer King, Carl Jacobs, David Robertson, Marty Porter, Melanie Eley, Emmalee Nichols, Jennifer LaCorte, Melinda Mock, William Rogers, Fernando Ovalle, David Bell, Vijay K. Misra, William B. Hillegass, Raed Aqel, Penny Pierce, Melanie Smith, Leah Saag, Ashley Vaughn, Dwight Smith, Tiffany Grimes, Susan Rolli, Roberta Hill, Beth Dean Barrett, Clarinda Morehead, Ken Doss, Charles J. Davidson, Mark Molitch, Nirat Beohar, Elaine Massaro, Lynne Goodreau, Fabiola Arroyo, Petr Neužil, Lenka Pavlíɥková, Štěpánka Stehlíková, Jaroslav Benedik, Liz Coling, Richard Davies, Christopher Glover, Michel LeMay, Thierry Mesana, Teik Chye Ooi, Mark Silverman, Alexander Sorisky, Colette Favreau, Susan McClinton, Melvin Weiss, Irene Weiss, Leo Saulle, Harichandra Kannam, Joanne C. Kurylas, Lorraine Vasi, John Douglas, Ziyad Ghazzal, Laurence Sperling, Priya Dayamani, Suzanne Gebhart, Sabreena Basu, Tarek Helmy, Vin Tangpricha, Pamela Hyde, Margaret Jenkins, Barbara P. Grant, Kenneth Kent, William Suddath, Patricia Julien-Williams, Vida Reed, Carine Nassar, Gilles Dagenais, Claude Garceau, Dominique Auger, Christopher Buller, Tom Elliott, Krishnan Ramanathan, Donald Ricci, Rebecca Fox, Daniela Kolesniak, Michael Attubato, Frederick Feit, Stephen Richardson, Ivan Pena Sing, James Slater, Angela Amendola, Bernardo Vargas, Nicholas Tsapatsaris, Bartholomew Woods, Gary Cushing, Martin K. Rutter, Premranjan Singh, Gail DesRochers, Gail Woodhead, Deborah Gannon, Nancy Shinopulos Campbell, Michael Ragosta, Ian Sarembock, Eric Powers, Eugene Barrett, Linda Jahn, Karen Murie, Gladwin Das, Gardar Sigurdsson, Carl White, John Bantle, J. Bruce Redmon, Christine Kwong, Jeanine Albu, Judith S. Hochman, James Wilentz, Sylvaine Frances, Deborah Tormey, Carl Pepine, Karen Smith, Laurence Kennedy, Karen Brezner, Tempa Curry, Frank Bleyer, Stewart Albert, Arshag Mooradian, Sharon Plummer, Francisco Fuentes, Roberto Robles, Victor Lavis, Jaime Gomez, Cesar Iliescu, Carol Underwood, Maria Selin Fulton, Julie Gomez Ramirez, Jennifer Merta, Glenna Scott, Ashok Krishnaswami, Lynn Dowdell, Sarah Berkheimer, Adam Greenbaum, Fred Whitehouse, Raquel Pangilinan, Kelly Mann, Elliot Sternthal, Susana Ebner, Zoran Nedeljkovic, Paula Beardsley, David Schneider, Richard Pratley, William Cefalu, Joel Schnure, Michaelanne Rowen, Linda Tilton, Alan Niederman, Cristina Mata, Terri Kellerman, John Farmer, Alan J. Garber, Neal Kleiman, Nancy Howard, Debra Nichols, Madonna Pool, Christopher Granger, Mark Feinglos, George Adams, Jennifer Green, Bernadette Druken, Dani Underwood, J. Lawrence Stafford, Thomas Donner, Warren Laskey, Dana Beach, John Lopez, Andrew Davis, David Faxon, Sirimon Reutrakul, Emily Bayer, Oscar Marroquin, Howard Cohen, Mary Korytkowski, Glory Koerbel, Lisa Baxendell, Debbie Rosenfelder, Louise DeRiso, Carole Farrell, Tina Vita, Janet McGill, Ronald Krone, Richard Bach, Carol Recklein, Kristin M. Luepke, Mary Jane Clifton, Michael E. Farkouh, Michael C. Kim, Donald A. Smith, Ida Guzman, Arlene Travis, James O'Keefe, Alan Forker, William Isley, Richard Moe, Paul Kennedy, Margaret Rosson, Aimee Long, Eric Bates, William Herman, Rodica Pop-Busui, Claire Duvernoy, Martin Stevens, Ann Luciano, Cheryl Majors, Sheldon H. Gottlieb, Annabelle Rodriguez, Melanie Herr, David Williams, Robert J. Smith, Dawn J. Bbott, Marc J. Laufgraben, Mary Grogan, Janice Muratori, Gabriel Habib, Marco Marcelli, Issam Mikati, Emilia Cordero, Gina Caldwell, David Chechter, Daniel Lorber, Phyllis August, Maisie Brown, Patricia Depree, Kurt Huber, Ursula Hanusch-Enserer, Nelly Jordanova, Dilek Cilesiz, Birgit Vogel, Ben McCallister, Michael Kleerekoper, Kelly Mandagere, Robert Urbanic, James Bengston, Bobby K. Kong, Andrew Pruitt, Jeffrey Sanfield, Carol Carulli, Ruth Churley-Strom, Raymond Magorien, Kwame Osei, Cecilia Casey Boyer, Richard Lee, Pasquale Palumbo, Joyce Wisbey, Edwin Alderman, Fumiaki Ikeno, Anne Schwarzkopf, Michael Steffes, Maren Nowicki, Jean Bucksa, Bernard Chaitman, Jane Eckstein, Karen Stocke, Mark A. Hlatky, Derek B. Boothroyd, Kathryn A. Melsop, Burton E. Sobel, Dagnija Neimane, Ami E. Iskandrian, Mary Beth Schaaf, Saul Genuth, Theresa Bongarno, Richard Nesto, Karen Hultberg, Helene Rosenhouse-Romeo, Georgia Pambianco, Michael Mock, L. Z.Jones Teresa, Thomas Ryan, Harold Lebovitz, Robert Brown, Gottlieb Friesinger, Edward Horton, Jay Mason, Renu Virmani, Lawrence Wechsler, C. Noel Bairey-Merz, Ward J. Ennedy, Elliott Antman, John Colwell, Sarah Fowler, Curt Furberg, Lee Goldman, Bruce Jennings, Scott Rankin

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background. Research has shown less aggressive treatment and poorer control of cardiovascular disease (CVD) risk factors in women than men. Methods. We analyzed sex differences in pharmacotherapy strategies and attainment of goals for hemoglobin A1c (HbA1c), blood pressure (BP), and low density lipoprotein cholesterol (LDL-C) in patients with type 2 diabetes and established coronary artery disease enrolled into the BARI 2D trial. Results. Similar numbers of drugs were prescribed in both women and men. Women were less frequent on metformin or sulfonylurea and more likely to take insulin and to be on higher doses of hydroxymethylglutaryl-CoA reductase inhibitors (statins) than men. After adjusting for baseline differences and treatment prescribed, women were less likely to achieve goals for HbA1c (OR = 0.71, 95% CI 0.57, 0.88) and LDL-C (OR = 0.64, 95% CI 0.53, 0.78). More antihypertensives were prescribed to women, and yet BP ≤ 130/80 mmHg did not differ by sex. Conclusions. Women entering the BARI 2D trial were as aggressively treated with drugs as men. Despite equivalent treatment, women less frequently met targets for HbA1c and LDL-C. Our findings suggest that there may be sex differences in response to drug therapies used to treat diabetes, hypertension, and hyperlipidemia.

Original languageEnglish (US)
Article number610239
JournalInternational Journal of Endocrinology
Volume2015
DOIs
StatePublished - Jan 1 2015

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Practice Guidelines
LDL Cholesterol
Blood Pressure
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Sex Characteristics
Hemoglobins
Drug Therapy
Methemoglobin
Metformin
Hyperlipidemias
Pharmaceutical Preparations
Type 2 Diabetes Mellitus
Antihypertensive Agents
Coronary Artery Disease
Cardiovascular Diseases
Therapeutics
Insulin
Hypertension
Research

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems

Cite this

Sex, prescribing practices and guideline recommended, blood pressure, and LDL cholesterol targets at baseline in the BARI 2D trial. / Magee, Michelle F.; Tamis-Holland, Jacqueline E.; Lu, Jiang; Bittner, Vera A.; Brooks, Maria Mori; Lopes, Neuza; Jacobs, Alice K.; Detre, Katherine M.; Kelsey, Sheryl F.; Orchard, Trevor J.; Thomas, Stephen B.; Tyrrell, Kim Sutton; Rana, Jamal S.; Averbach, Frani; MacGregor, Joan M.; O'Neal, Scott M.; Pitluga, Kathleen; Sansing, Veronica; Tranchine, Mary; Crow, Sharon W.; Bertolet, Marianne; Hardison, Regina; Kip, Kevin; Lombardero, Manuel; Janiszewski, Sue; Protivnak, Darina; Reiser, Sarah; Barton, Stephen; Guo, Ping; Kushner, Yulia; Martin, Jeffrey P.; Kania, Christopher; Kania, Michael; O'Donnell, Jeffrey; Maxwell, Rae Ann; Frye, Robert L.; Goldberg, Suzanne; Rosenberg, Yves; Desvigne-Nickens, Patrice; Ershow, Abby; Gordon, David; Paltoo, Dina; Jones, Teresa L.Z.; Hueb, Whady; Ramires, José; Wajchenberg, Bernardo Léo; Martinez, Eulogio E.; Oliveira, Sergio A.; Ribeiro, Expedito E.; Perin, Marcos; Betti, Roberto; Schwartz, Leonard; Steiner, George; Barolet, Alan; Groenewoud, Yolanda; Mighton, Lisa; Camelon, Kathy; O'Rourke, Robert; Blodgett, Janet; Sako, Edward; Nicastro, Judith; Prescott, Robin; Rihal, Charanjit; Kennedy, Frank; Barsness, Gregory; Basu, Amanda; Clavell, Alfredo; Frye, Robert; Holmes, David R.; Lerman, Amir; Mullaney, Charles; Reeder, Guy; Rizza, Robert; Schaff, Hartzell; Smith, Steven; Somers, Virend; Sundt, Thoralf; Ting, Henry; Wright, R. Scott; Helgemoe, Pam; Lesmeister, Diane; Rolbiecki, Deborah; Lepe-Montoya, Luis; Escobedo, Jorge; Barraza, Rafael; Baleón, Rubén; Campos, Arturo; García, Paula; Lezama, Carlos; Miramontes, Carlos; Ocampo, Salvador; Peñafiel, Joaquí; Valdespino, Aquiles; Verdín, Raúl; Albarrán, Hé; Ayala, Fernando; Chávez, Eduardo; Murillo, Hé; Buitrón, Luisa Virginia; Rico-Verdin, Beatriz; Angulo, Fabiola; Adler, Dale; Arthur Halle, Austin; Ismail-Beigi, Faramarz; Paranjape, Suvinay; Mazzurco, Stacey; Ridley, Karen; Ramanathan, K; Solomon, Solomon; Wall, Barry; Weinman, Darryl; Touchstone, Tammy; Douglas, Lillie; Bourassa, Martial; Tardif, Jean Claude; Chiasson, Jean Louis; Andre Lavoie, Marc; Rabasa-Lhoret, Rémi; Langelier, Hélène; Foucher, Suzy; Trudel, Johanne; Monrad, Scott; Srinivas, Vankeepuram; Zonszein, Joel; Crandall, Jill; Duffy, Helena; Vartolomei, Eugen; King, Spencer; Jacobs, Carl; Robertson, David; Porter, Marty; Eley, Melanie; Nichols, Emmalee; LaCorte, Jennifer; Mock, Melinda; Rogers, William; Ovalle, Fernando; Bell, David; Misra, Vijay K.; Hillegass, William B.; Aqel, Raed; Pierce, Penny; Smith, Melanie; Saag, Leah; Vaughn, Ashley; Smith, Dwight; Grimes, Tiffany; Rolli, Susan; Hill, Roberta; Dean Barrett, Beth; Morehead, Clarinda; Doss, Ken; Davidson, Charles J.; Molitch, Mark; Beohar, Nirat; Massaro, Elaine; Goodreau, Lynne; Arroyo, Fabiola; Neužil, Petr; Pavlíɥková, Lenka; Stehlíková, Štěpánka; Benedik, Jaroslav; Coling, Liz; Davies, Richard; Glover, Christopher; LeMay, Michel; Mesana, Thierry; Ooi, Teik Chye; Silverman, Mark; Sorisky, Alexander; Favreau, Colette; McClinton, Susan; Weiss, Melvin; Weiss, Irene; Saulle, Leo; Kannam, Harichandra; Kurylas, Joanne C.; Vasi, Lorraine; Douglas, John; Ghazzal, Ziyad; Sperling, Laurence; Dayamani, Priya; Gebhart, Suzanne; Basu, Sabreena; Helmy, Tarek; Tangpricha, Vin; Hyde, Pamela; Jenkins, Margaret; Grant, Barbara P.; Kent, Kenneth; Suddath, William; Julien-Williams, Patricia; Reed, Vida; Nassar, Carine; Dagenais, Gilles; Garceau, Claude; Auger, Dominique; Buller, Christopher; Elliott, Tom; Ramanathan, Krishnan; Ricci, Donald; Fox, Rebecca; Kolesniak, Daniela; Attubato, Michael; Feit, Frederick; Richardson, Stephen; Sing, Ivan Pena; Slater, James; Amendola, Angela; Vargas, Bernardo; Tsapatsaris, Nicholas; Woods, Bartholomew; Cushing, Gary; Rutter, Martin K.; Singh, Premranjan; DesRochers, Gail; Woodhead, Gail; Gannon, Deborah; Campbell, Nancy Shinopulos; Ragosta, Michael; Sarembock, Ian; Powers, Eric; Barrett, Eugene; Jahn, Linda; Murie, Karen; Das, Gladwin; Sigurdsson, Gardar; White, Carl; Bantle, John; Redmon, J. Bruce; Kwong, Christine; Albu, Jeanine; Hochman, Judith S.; Wilentz, James; Frances, Sylvaine; Tormey, Deborah; Pepine, Carl; Smith, Karen; Kennedy, Laurence; Brezner, Karen; Curry, Tempa; Bleyer, Frank; Albert, Stewart; Mooradian, Arshag; Plummer, Sharon; Fuentes, Francisco; Robles, Roberto; Lavis, Victor; Gomez, Jaime; Iliescu, Cesar; Underwood, Carol; Fulton, Maria Selin; Ramirez, Julie Gomez; Merta, Jennifer; Scott, Glenna; Krishnaswami, Ashok; Dowdell, Lynn; Berkheimer, Sarah; Greenbaum, Adam; Whitehouse, Fred; Pangilinan, Raquel; Mann, Kelly; Sternthal, Elliot; Ebner, Susana; Nedeljkovic, Zoran; Beardsley, Paula; Schneider, David; Pratley, Richard; Cefalu, William; Schnure, Joel; Rowen, Michaelanne; Tilton, Linda; Niederman, Alan; Mata, Cristina; Kellerman, Terri; Farmer, John; Garber, Alan J.; Kleiman, Neal; Howard, Nancy; Nichols, Debra; Pool, Madonna; Granger, Christopher; Feinglos, Mark; Adams, George; Green, Jennifer; Druken, Bernadette; Underwood, Dani; Stafford, J. Lawrence; Donner, Thomas; Laskey, Warren; Beach, Dana; Lopez, John; Davis, Andrew; Faxon, David; Reutrakul, Sirimon; Bayer, Emily; Marroquin, Oscar; Cohen, Howard; Korytkowski, Mary; Koerbel, Glory; Baxendell, Lisa; Rosenfelder, Debbie; DeRiso, Louise; Farrell, Carole; Vita, Tina; McGill, Janet; Krone, Ronald; Bach, Richard; Recklein, Carol; Luepke, Kristin M.; Clifton, Mary Jane; Farkouh, Michael E.; Kim, Michael C.; Smith, Donald A.; Guzman, Ida; Travis, Arlene; O'Keefe, James; Forker, Alan; Isley, William; Moe, Richard; Kennedy, Paul; Rosson, Margaret; Long, Aimee; Bates, Eric; Herman, William; Pop-Busui, Rodica; Duvernoy, Claire; Stevens, Martin; Luciano, Ann; Majors, Cheryl; Gottlieb, Sheldon H.; Rodriguez, Annabelle; Herr, Melanie; Williams, David; Smith, Robert J.; Bbott, Dawn J.; Laufgraben, Marc J.; Grogan, Mary; Muratori, Janice; Habib, Gabriel; Marcelli, Marco; Mikati, Issam; Cordero, Emilia; Caldwell, Gina; Chechter, David; Lorber, Daniel; August, Phyllis; Brown, Maisie; Depree, Patricia; Huber, Kurt; Hanusch-Enserer, Ursula; Jordanova, Nelly; Cilesiz, Dilek; Vogel, Birgit; McCallister, Ben; Kleerekoper, Michael; Mandagere, Kelly; Urbanic, Robert; Bengston, James; Kong, Bobby K.; Pruitt, Andrew; Sanfield, Jeffrey; Carulli, Carol; Churley-Strom, Ruth; Magorien, Raymond; Osei, Kwame; Boyer, Cecilia Casey; Lee, Richard; Palumbo, Pasquale; Wisbey, Joyce; Alderman, Edwin; Ikeno, Fumiaki; Schwarzkopf, Anne; Steffes, Michael; Nowicki, Maren; Bucksa, Jean; Chaitman, Bernard; Eckstein, Jane; Stocke, Karen; Hlatky, Mark A.; Boothroyd, Derek B.; Melsop, Kathryn A.; Sobel, Burton E.; Neimane, Dagnija; Iskandrian, Ami E.; Schaaf, Mary Beth; Genuth, Saul; Bongarno, Theresa; Nesto, Richard; Hultberg, Karen; Rosenhouse-Romeo, Helene; Pambianco, Georgia; Mock, Michael; Teresa, L. Z.Jones; Ryan, Thomas; Lebovitz, Harold; Brown, Robert; Friesinger, Gottlieb; Horton, Edward; Mason, Jay; Virmani, Renu; Wechsler, Lawrence; Bairey-Merz, C. Noel; J. Ennedy, Ward; Antman, Elliott; Colwell, John; Fowler, Sarah; Furberg, Curt; Goldman, Lee; Jennings, Bruce; Rankin, Scott.

In: International Journal of Endocrinology, Vol. 2015, 610239, 01.01.2015.

Research output: Contribution to journalArticle

Magee, MF, Tamis-Holland, JE, Lu, J, Bittner, VA, Brooks, MM, Lopes, N, Jacobs, AK, Detre, KM, Kelsey, SF, Orchard, TJ, Thomas, SB, Tyrrell, KS, Rana, JS, Averbach, F, MacGregor, JM, O'Neal, SM, Pitluga, K, Sansing, V, Tranchine, M, Crow, SW, Bertolet, M, Hardison, R, Kip, K, Lombardero, M, Janiszewski, S, Protivnak, D, Reiser, S, Barton, S, Guo, P, Kushner, Y, Martin, JP, Kania, C, Kania, M, O'Donnell, J, Maxwell, RA, Frye, RL, Goldberg, S, Rosenberg, Y, Desvigne-Nickens, P, Ershow, A, Gordon, D, Paltoo, D, Jones, TLZ, Hueb, W, Ramires, J, Wajchenberg, BL, Martinez, EE, Oliveira, SA, Ribeiro, EE, Perin, M, Betti, R, Schwartz, L, Steiner, G, Barolet, A, Groenewoud, Y, Mighton, L, Camelon, K, O'Rourke, R, Blodgett, J, Sako, E, Nicastro, J, Prescott, R, Rihal, C, Kennedy, F, Barsness, G, Basu, A, Clavell, A, Frye, R, Holmes, DR, Lerman, A, Mullaney, C, Reeder, G, Rizza, R, Schaff, H, Smith, S, Somers, V, Sundt, T, Ting, H, Wright, RS, Helgemoe, P, Lesmeister, D, Rolbiecki, D, Lepe-Montoya, L, Escobedo, J, Barraza, R, Baleón, R, Campos, A, García, P, Lezama, C, Miramontes, C, Ocampo, S, Peñafiel, J, Valdespino, A, Verdín, R, Albarrán, H, Ayala, F, Chávez, E, Murillo, H, Buitrón, LV, Rico-Verdin, B, Angulo, F, Adler, D, Arthur Halle, A, Ismail-Beigi, F, Paranjape, S, Mazzurco, S, Ridley, K, Ramanathan, K, Solomon, S, Wall, B, Weinman, D, Touchstone, T, Douglas, L, Bourassa, M, Tardif, JC, Chiasson, JL, Andre Lavoie, M, Rabasa-Lhoret, R, Langelier, H, Foucher, S, Trudel, J, Monrad, S, Srinivas, V, Zonszein, J, Crandall, J, Duffy, H, Vartolomei, E, King, S, Jacobs, C, Robertson, D, Porter, M, Eley, M, Nichols, E, LaCorte, J, Mock, M, Rogers, W, Ovalle, F, Bell, D, Misra, VK, Hillegass, WB, Aqel, R, Pierce, P, Smith, M, Saag, L, Vaughn, A, Smith, D, Grimes, T, Rolli, S, Hill, R, Dean Barrett, B, Morehead, C, Doss, K, Davidson, CJ, Molitch, M, Beohar, N, Massaro, E, Goodreau, L, Arroyo, F, Neužil, P, Pavlíɥková, L, Stehlíková, Š, Benedik, J, Coling, L, Davies, R, Glover, C, LeMay, M, Mesana, T, Ooi, TC, Silverman, M, Sorisky, A, Favreau, C, McClinton, S, Weiss, M, Weiss, I, Saulle, L, Kannam, H, Kurylas, JC, Vasi, L, Douglas, J, Ghazzal, Z, Sperling, L, Dayamani, P, Gebhart, S, Basu, S, Helmy, T, Tangpricha, V, Hyde, P, Jenkins, M, Grant, BP, Kent, K, Suddath, W, Julien-Williams, P, Reed, V, Nassar, C, Dagenais, G, Garceau, C, Auger, D, Buller, C, Elliott, T, Ramanathan, K, Ricci, D, Fox, R, Kolesniak, D, Attubato, M, Feit, F, Richardson, S, Sing, IP, Slater, J, Amendola, A, Vargas, B, Tsapatsaris, N, Woods, B, Cushing, G, Rutter, MK, Singh, P, DesRochers, G, Woodhead, G, Gannon, D, Campbell, NS, Ragosta, M, Sarembock, I, Powers, E, Barrett, E, Jahn, L, Murie, K, Das, G, Sigurdsson, G, White, C, Bantle, J, Redmon, JB, Kwong, C, Albu, J, Hochman, JS, Wilentz, J, Frances, S, Tormey, D, Pepine, C, Smith, K, Kennedy, L, Brezner, K, Curry, T, Bleyer, F, Albert, S, Mooradian, A, Plummer, S, Fuentes, F, Robles, R, Lavis, V, Gomez, J, Iliescu, C, Underwood, C, Fulton, MS, Ramirez, JG, Merta, J, Scott, G, Krishnaswami, A, Dowdell, L, Berkheimer, S, Greenbaum, A, Whitehouse, F, Pangilinan, R, Mann, K, Sternthal, E, Ebner, S, Nedeljkovic, Z, Beardsley, P, Schneider, D, Pratley, R, Cefalu, W, Schnure, J, Rowen, M, Tilton, L, Niederman, A, Mata, C, Kellerman, T, Farmer, J, Garber, AJ, Kleiman, N, Howard, N, Nichols, D, Pool, M, Granger, C, Feinglos, M, Adams, G, Green, J, Druken, B, Underwood, D, Stafford, JL, Donner, T, Laskey, W, Beach, D, Lopez, J, Davis, A, Faxon, D, Reutrakul, S, Bayer, E, Marroquin, O, Cohen, H, Korytkowski, M, Koerbel, G, Baxendell, L, Rosenfelder, D, DeRiso, L, Farrell, C, Vita, T, McGill, J, Krone, R, Bach, R, Recklein, C, Luepke, KM, Clifton, MJ, Farkouh, ME, Kim, MC, Smith, DA, Guzman, I, Travis, A, O'Keefe, J, Forker, A, Isley, W, Moe, R, Kennedy, P, Rosson, M, Long, A, Bates, E, Herman, W, Pop-Busui, R, Duvernoy, C, Stevens, M, Luciano, A, Majors, C, Gottlieb, SH, Rodriguez, A, Herr, M, Williams, D, Smith, RJ, Bbott, DJ, Laufgraben, MJ, Grogan, M, Muratori, J, Habib, G, Marcelli, M, Mikati, I, Cordero, E, Caldwell, G, Chechter, D, Lorber, D, August, P, Brown, M, Depree, P, Huber, K, Hanusch-Enserer, U, Jordanova, N, Cilesiz, D, Vogel, B, McCallister, B, Kleerekoper, M, Mandagere, K, Urbanic, R, Bengston, J, Kong, BK, Pruitt, A, Sanfield, J, Carulli, C, Churley-Strom, R, Magorien, R, Osei, K, Boyer, CC, Lee, R, Palumbo, P, Wisbey, J, Alderman, E, Ikeno, F, Schwarzkopf, A, Steffes, M, Nowicki, M, Bucksa, J, Chaitman, B, Eckstein, J, Stocke, K, Hlatky, MA, Boothroyd, DB, Melsop, KA, Sobel, BE, Neimane, D, Iskandrian, AE, Schaaf, MB, Genuth, S, Bongarno, T, Nesto, R, Hultberg, K, Rosenhouse-Romeo, H, Pambianco, G, Mock, M, Teresa, LZJ, Ryan, T, Lebovitz, H, Brown, R, Friesinger, G, Horton, E, Mason, J, Virmani, R, Wechsler, L, Bairey-Merz, CN, J. Ennedy, W, Antman, E, Colwell, J, Fowler, S, Furberg, C, Goldman, L, Jennings, B & Rankin, S 2015, 'Sex, prescribing practices and guideline recommended, blood pressure, and LDL cholesterol targets at baseline in the BARI 2D trial', International Journal of Endocrinology, vol. 2015, 610239. https://doi.org/10.1155/2015/610239
Magee, Michelle F. ; Tamis-Holland, Jacqueline E. ; Lu, Jiang ; Bittner, Vera A. ; Brooks, Maria Mori ; Lopes, Neuza ; Jacobs, Alice K. ; Detre, Katherine M. ; Kelsey, Sheryl F. ; Orchard, Trevor J. ; Thomas, Stephen B. ; Tyrrell, Kim Sutton ; Rana, Jamal S. ; Averbach, Frani ; MacGregor, Joan M. ; O'Neal, Scott M. ; Pitluga, Kathleen ; Sansing, Veronica ; Tranchine, Mary ; Crow, Sharon W. ; Bertolet, Marianne ; Hardison, Regina ; Kip, Kevin ; Lombardero, Manuel ; Janiszewski, Sue ; Protivnak, Darina ; Reiser, Sarah ; Barton, Stephen ; Guo, Ping ; Kushner, Yulia ; Martin, Jeffrey P. ; Kania, Christopher ; Kania, Michael ; O'Donnell, Jeffrey ; Maxwell, Rae Ann ; Frye, Robert L. ; Goldberg, Suzanne ; Rosenberg, Yves ; Desvigne-Nickens, Patrice ; Ershow, Abby ; Gordon, David ; Paltoo, Dina ; Jones, Teresa L.Z. ; Hueb, Whady ; Ramires, José ; Wajchenberg, Bernardo Léo ; Martinez, Eulogio E. ; Oliveira, Sergio A. ; Ribeiro, Expedito E. ; Perin, Marcos ; Betti, Roberto ; Schwartz, Leonard ; Steiner, George ; Barolet, Alan ; Groenewoud, Yolanda ; Mighton, Lisa ; Camelon, Kathy ; O'Rourke, Robert ; Blodgett, Janet ; Sako, Edward ; Nicastro, Judith ; Prescott, Robin ; Rihal, Charanjit ; Kennedy, Frank ; Barsness, Gregory ; Basu, Amanda ; Clavell, Alfredo ; Frye, Robert ; Holmes, David R. ; Lerman, Amir ; Mullaney, Charles ; Reeder, Guy ; Rizza, Robert ; Schaff, Hartzell ; Smith, Steven ; Somers, Virend ; Sundt, Thoralf ; Ting, Henry ; Wright, R. Scott ; Helgemoe, Pam ; Lesmeister, Diane ; Rolbiecki, Deborah ; Lepe-Montoya, Luis ; Escobedo, Jorge ; Barraza, Rafael ; Baleón, Rubén ; Campos, Arturo ; García, Paula ; Lezama, Carlos ; Miramontes, Carlos ; Ocampo, Salvador ; Peñafiel, Joaquí ; Valdespino, Aquiles ; Verdín, Raúl ; Albarrán, Hé ; Ayala, Fernando ; Chávez, Eduardo ; Murillo, Hé ; Buitrón, Luisa Virginia ; Rico-Verdin, Beatriz ; Angulo, Fabiola ; Adler, Dale ; Arthur Halle, Austin ; Ismail-Beigi, Faramarz ; Paranjape, Suvinay ; Mazzurco, Stacey ; Ridley, Karen ; Ramanathan, K ; Solomon, Solomon ; Wall, Barry ; Weinman, Darryl ; Touchstone, Tammy ; Douglas, Lillie ; Bourassa, Martial ; Tardif, Jean Claude ; Chiasson, Jean Louis ; Andre Lavoie, Marc ; Rabasa-Lhoret, Rémi ; Langelier, Hélène ; Foucher, Suzy ; Trudel, Johanne ; Monrad, Scott ; Srinivas, Vankeepuram ; Zonszein, Joel ; Crandall, Jill ; Duffy, Helena ; Vartolomei, Eugen ; King, Spencer ; Jacobs, Carl ; Robertson, David ; Porter, Marty ; Eley, Melanie ; Nichols, Emmalee ; LaCorte, Jennifer ; Mock, Melinda ; Rogers, William ; Ovalle, Fernando ; Bell, David ; Misra, Vijay K. ; Hillegass, William B. ; Aqel, Raed ; Pierce, Penny ; Smith, Melanie ; Saag, Leah ; Vaughn, Ashley ; Smith, Dwight ; Grimes, Tiffany ; Rolli, Susan ; Hill, Roberta ; Dean Barrett, Beth ; Morehead, Clarinda ; Doss, Ken ; Davidson, Charles J. ; Molitch, Mark ; Beohar, Nirat ; Massaro, Elaine ; Goodreau, Lynne ; Arroyo, Fabiola ; Neužil, Petr ; Pavlíɥková, Lenka ; Stehlíková, Štěpánka ; Benedik, Jaroslav ; Coling, Liz ; Davies, Richard ; Glover, Christopher ; LeMay, Michel ; Mesana, Thierry ; Ooi, Teik Chye ; Silverman, Mark ; Sorisky, Alexander ; Favreau, Colette ; McClinton, Susan ; Weiss, Melvin ; Weiss, Irene ; Saulle, Leo ; Kannam, Harichandra ; Kurylas, Joanne C. ; Vasi, Lorraine ; Douglas, John ; Ghazzal, Ziyad ; Sperling, Laurence ; Dayamani, Priya ; Gebhart, Suzanne ; Basu, Sabreena ; Helmy, Tarek ; Tangpricha, Vin ; Hyde, Pamela ; Jenkins, Margaret ; Grant, Barbara P. ; Kent, Kenneth ; Suddath, William ; Julien-Williams, Patricia ; Reed, Vida ; Nassar, Carine ; Dagenais, Gilles ; Garceau, Claude ; Auger, Dominique ; Buller, Christopher ; Elliott, Tom ; Ramanathan, Krishnan ; Ricci, Donald ; Fox, Rebecca ; Kolesniak, Daniela ; Attubato, Michael ; Feit, Frederick ; Richardson, Stephen ; Sing, Ivan Pena ; Slater, James ; Amendola, Angela ; Vargas, Bernardo ; Tsapatsaris, Nicholas ; Woods, Bartholomew ; Cushing, Gary ; Rutter, Martin K. ; Singh, Premranjan ; DesRochers, Gail ; Woodhead, Gail ; Gannon, Deborah ; Campbell, Nancy Shinopulos ; Ragosta, Michael ; Sarembock, Ian ; Powers, Eric ; Barrett, Eugene ; Jahn, Linda ; Murie, Karen ; Das, Gladwin ; Sigurdsson, Gardar ; White, Carl ; Bantle, John ; Redmon, J. Bruce ; Kwong, Christine ; Albu, Jeanine ; Hochman, Judith S. ; Wilentz, James ; Frances, Sylvaine ; Tormey, Deborah ; Pepine, Carl ; Smith, Karen ; Kennedy, Laurence ; Brezner, Karen ; Curry, Tempa ; Bleyer, Frank ; Albert, Stewart ; Mooradian, Arshag ; Plummer, Sharon ; Fuentes, Francisco ; Robles, Roberto ; Lavis, Victor ; Gomez, Jaime ; Iliescu, Cesar ; Underwood, Carol ; Fulton, Maria Selin ; Ramirez, Julie Gomez ; Merta, Jennifer ; Scott, Glenna ; Krishnaswami, Ashok ; Dowdell, Lynn ; Berkheimer, Sarah ; Greenbaum, Adam ; Whitehouse, Fred ; Pangilinan, Raquel ; Mann, Kelly ; Sternthal, Elliot ; Ebner, Susana ; Nedeljkovic, Zoran ; Beardsley, Paula ; Schneider, David ; Pratley, Richard ; Cefalu, William ; Schnure, Joel ; Rowen, Michaelanne ; Tilton, Linda ; Niederman, Alan ; Mata, Cristina ; Kellerman, Terri ; Farmer, John ; Garber, Alan J. ; Kleiman, Neal ; Howard, Nancy ; Nichols, Debra ; Pool, Madonna ; Granger, Christopher ; Feinglos, Mark ; Adams, George ; Green, Jennifer ; Druken, Bernadette ; Underwood, Dani ; Stafford, J. Lawrence ; Donner, Thomas ; Laskey, Warren ; Beach, Dana ; Lopez, John ; Davis, Andrew ; Faxon, David ; Reutrakul, Sirimon ; Bayer, Emily ; Marroquin, Oscar ; Cohen, Howard ; Korytkowski, Mary ; Koerbel, Glory ; Baxendell, Lisa ; Rosenfelder, Debbie ; DeRiso, Louise ; Farrell, Carole ; Vita, Tina ; McGill, Janet ; Krone, Ronald ; Bach, Richard ; Recklein, Carol ; Luepke, Kristin M. ; Clifton, Mary Jane ; Farkouh, Michael E. ; Kim, Michael C. ; Smith, Donald A. ; Guzman, Ida ; Travis, Arlene ; O'Keefe, James ; Forker, Alan ; Isley, William ; Moe, Richard ; Kennedy, Paul ; Rosson, Margaret ; Long, Aimee ; Bates, Eric ; Herman, William ; Pop-Busui, Rodica ; Duvernoy, Claire ; Stevens, Martin ; Luciano, Ann ; Majors, Cheryl ; Gottlieb, Sheldon H. ; Rodriguez, Annabelle ; Herr, Melanie ; Williams, David ; Smith, Robert J. ; Bbott, Dawn J. ; Laufgraben, Marc J. ; Grogan, Mary ; Muratori, Janice ; Habib, Gabriel ; Marcelli, Marco ; Mikati, Issam ; Cordero, Emilia ; Caldwell, Gina ; Chechter, David ; Lorber, Daniel ; August, Phyllis ; Brown, Maisie ; Depree, Patricia ; Huber, Kurt ; Hanusch-Enserer, Ursula ; Jordanova, Nelly ; Cilesiz, Dilek ; Vogel, Birgit ; McCallister, Ben ; Kleerekoper, Michael ; Mandagere, Kelly ; Urbanic, Robert ; Bengston, James ; Kong, Bobby K. ; Pruitt, Andrew ; Sanfield, Jeffrey ; Carulli, Carol ; Churley-Strom, Ruth ; Magorien, Raymond ; Osei, Kwame ; Boyer, Cecilia Casey ; Lee, Richard ; Palumbo, Pasquale ; Wisbey, Joyce ; Alderman, Edwin ; Ikeno, Fumiaki ; Schwarzkopf, Anne ; Steffes, Michael ; Nowicki, Maren ; Bucksa, Jean ; Chaitman, Bernard ; Eckstein, Jane ; Stocke, Karen ; Hlatky, Mark A. ; Boothroyd, Derek B. ; Melsop, Kathryn A. ; Sobel, Burton E. ; Neimane, Dagnija ; Iskandrian, Ami E. ; Schaaf, Mary Beth ; Genuth, Saul ; Bongarno, Theresa ; Nesto, Richard ; Hultberg, Karen ; Rosenhouse-Romeo, Helene ; Pambianco, Georgia ; Mock, Michael ; Teresa, L. Z.Jones ; Ryan, Thomas ; Lebovitz, Harold ; Brown, Robert ; Friesinger, Gottlieb ; Horton, Edward ; Mason, Jay ; Virmani, Renu ; Wechsler, Lawrence ; Bairey-Merz, C. Noel ; J. Ennedy, Ward ; Antman, Elliott ; Colwell, John ; Fowler, Sarah ; Furberg, Curt ; Goldman, Lee ; Jennings, Bruce ; Rankin, Scott. / Sex, prescribing practices and guideline recommended, blood pressure, and LDL cholesterol targets at baseline in the BARI 2D trial. In: International Journal of Endocrinology. 2015 ; Vol. 2015.
@article{3208f7d1c9bb45a486c1fc165e568c0c,
title = "Sex, prescribing practices and guideline recommended, blood pressure, and LDL cholesterol targets at baseline in the BARI 2D trial",
abstract = "Background. Research has shown less aggressive treatment and poorer control of cardiovascular disease (CVD) risk factors in women than men. Methods. We analyzed sex differences in pharmacotherapy strategies and attainment of goals for hemoglobin A1c (HbA1c), blood pressure (BP), and low density lipoprotein cholesterol (LDL-C) in patients with type 2 diabetes and established coronary artery disease enrolled into the BARI 2D trial. Results. Similar numbers of drugs were prescribed in both women and men. Women were less frequent on metformin or sulfonylurea and more likely to take insulin and to be on higher doses of hydroxymethylglutaryl-CoA reductase inhibitors (statins) than men. After adjusting for baseline differences and treatment prescribed, women were less likely to achieve goals for HbA1c (OR = 0.71, 95{\%} CI 0.57, 0.88) and LDL-C (OR = 0.64, 95{\%} CI 0.53, 0.78). More antihypertensives were prescribed to women, and yet BP ≤ 130/80 mmHg did not differ by sex. Conclusions. Women entering the BARI 2D trial were as aggressively treated with drugs as men. Despite equivalent treatment, women less frequently met targets for HbA1c and LDL-C. Our findings suggest that there may be sex differences in response to drug therapies used to treat diabetes, hypertension, and hyperlipidemia.",
author = "Magee, {Michelle F.} and Tamis-Holland, {Jacqueline E.} and Jiang Lu and Bittner, {Vera A.} and Brooks, {Maria Mori} and Neuza Lopes and Jacobs, {Alice K.} and Detre, {Katherine M.} and Kelsey, {Sheryl F.} and Orchard, {Trevor J.} and Thomas, {Stephen B.} and Tyrrell, {Kim Sutton} and Rana, {Jamal S.} and Frani Averbach and MacGregor, {Joan M.} and O'Neal, {Scott M.} and Kathleen Pitluga and Veronica Sansing and Mary Tranchine and Crow, {Sharon W.} and Marianne Bertolet and Regina Hardison and Kevin Kip and Manuel Lombardero and Sue Janiszewski and Darina Protivnak and Sarah Reiser and Stephen Barton and Ping Guo and Yulia Kushner and Martin, {Jeffrey P.} and Christopher Kania and Michael Kania and Jeffrey O'Donnell and Maxwell, {Rae Ann} and Frye, {Robert L.} and Suzanne Goldberg and Yves Rosenberg and Patrice Desvigne-Nickens and Abby Ershow and David Gordon and Dina Paltoo and Jones, {Teresa L.Z.} and Whady Hueb and Jos{\'e} Ramires and Wajchenberg, {Bernardo L{\'e}o} and Martinez, {Eulogio E.} and Oliveira, {Sergio A.} and Ribeiro, {Expedito E.} and Marcos Perin and Roberto Betti and Leonard Schwartz and George Steiner and Alan Barolet and Yolanda Groenewoud and Lisa Mighton and Kathy Camelon and Robert O'Rourke and Janet Blodgett and Edward Sako and Judith Nicastro and Robin Prescott and Charanjit Rihal and Frank Kennedy and Gregory Barsness and Amanda Basu and Alfredo Clavell and Robert Frye and Holmes, {David R.} and Amir Lerman and Charles Mullaney and Guy Reeder and Robert Rizza and Hartzell Schaff and Steven Smith and Virend Somers and Thoralf Sundt and Henry Ting and Wright, {R. Scott} and Pam Helgemoe and Diane Lesmeister and Deborah Rolbiecki and Luis Lepe-Montoya and Jorge Escobedo and Rafael Barraza and Rub{\'e}n Bale{\'o}n and Arturo Campos and Paula Garc{\'i}a and Carlos Lezama and Carlos Miramontes and Salvador Ocampo and Joaqu{\'i} Pe{\~n}afiel and Aquiles Valdespino and Ra{\'u}l Verd{\'i}n and H{\'e} Albarr{\'a}n and Fernando Ayala and Eduardo Ch{\'a}vez and H{\'e} Murillo and Buitr{\'o}n, {Luisa Virginia} and Beatriz Rico-Verdin and Fabiola Angulo and Dale Adler and {Arthur Halle}, Austin and Faramarz Ismail-Beigi and Suvinay Paranjape and Stacey Mazzurco and Karen Ridley and K Ramanathan and Solomon Solomon and Barry Wall and Darryl Weinman and Tammy Touchstone and Lillie Douglas and Martial Bourassa and Tardif, {Jean Claude} and Chiasson, {Jean Louis} and {Andre Lavoie}, Marc and R{\'e}mi Rabasa-Lhoret and H{\'e}l{\`e}ne Langelier and Suzy Foucher and Johanne Trudel and Scott Monrad and Vankeepuram Srinivas and Joel Zonszein and Jill Crandall and Helena Duffy and Eugen Vartolomei and Spencer King and Carl Jacobs and David Robertson and Marty Porter and Melanie Eley and Emmalee Nichols and Jennifer LaCorte and Melinda Mock and William Rogers and Fernando Ovalle and David Bell and Misra, {Vijay K.} and Hillegass, {William B.} and Raed Aqel and Penny Pierce and Melanie Smith and Leah Saag and Ashley Vaughn and Dwight Smith and Tiffany Grimes and Susan Rolli and Roberta Hill and {Dean Barrett}, Beth and Clarinda Morehead and Ken Doss and Davidson, {Charles J.} and Mark Molitch and Nirat Beohar and Elaine Massaro and Lynne Goodreau and Fabiola Arroyo and Petr Neužil and Lenka Pavl{\'i}ɥkov{\'a} and Štěp{\'a}nka Stehl{\'i}kov{\'a} and Jaroslav Benedik and Liz Coling and Richard Davies and Christopher Glover and Michel LeMay and Thierry Mesana and Ooi, {Teik Chye} and Mark Silverman and Alexander Sorisky and Colette Favreau and Susan McClinton and Melvin Weiss and Irene Weiss and Leo Saulle and Harichandra Kannam and Kurylas, {Joanne C.} and Lorraine Vasi and John Douglas and Ziyad Ghazzal and Laurence Sperling and Priya Dayamani and Suzanne Gebhart and Sabreena Basu and Tarek Helmy and Vin Tangpricha and Pamela Hyde and Margaret Jenkins and Grant, {Barbara P.} and Kenneth Kent and William Suddath and Patricia Julien-Williams and Vida Reed and Carine Nassar and Gilles Dagenais and Claude Garceau and Dominique Auger and Christopher Buller and Tom Elliott and Krishnan Ramanathan and Donald Ricci and Rebecca Fox and Daniela Kolesniak and Michael Attubato and Frederick Feit and Stephen Richardson and Sing, {Ivan Pena} and James Slater and Angela Amendola and Bernardo Vargas and Nicholas Tsapatsaris and Bartholomew Woods and Gary Cushing and Rutter, {Martin K.} and Premranjan Singh and Gail DesRochers and Gail Woodhead and Deborah Gannon and Campbell, {Nancy Shinopulos} and Michael Ragosta and Ian Sarembock and Eric Powers and Eugene Barrett and Linda Jahn and Karen Murie and Gladwin Das and Gardar Sigurdsson and Carl White and John Bantle and Redmon, {J. Bruce} and Christine Kwong and Jeanine Albu and Hochman, {Judith S.} and James Wilentz and Sylvaine Frances and Deborah Tormey and Carl Pepine and Karen Smith and Laurence Kennedy and Karen Brezner and Tempa Curry and Frank Bleyer and Stewart Albert and Arshag Mooradian and Sharon Plummer and Francisco Fuentes and Roberto Robles and Victor Lavis and Jaime Gomez and Cesar Iliescu and Carol Underwood and Fulton, {Maria Selin} and Ramirez, {Julie Gomez} and Jennifer Merta and Glenna Scott and Ashok Krishnaswami and Lynn Dowdell and Sarah Berkheimer and Adam Greenbaum and Fred Whitehouse and Raquel Pangilinan and Kelly Mann and Elliot Sternthal and Susana Ebner and Zoran Nedeljkovic and Paula Beardsley and David Schneider and Richard Pratley and William Cefalu and Joel Schnure and Michaelanne Rowen and Linda Tilton and Alan Niederman and Cristina Mata and Terri Kellerman and John Farmer and Garber, {Alan J.} and Neal Kleiman and Nancy Howard and Debra Nichols and Madonna Pool and Christopher Granger and Mark Feinglos and George Adams and Jennifer Green and Bernadette Druken and Dani Underwood and Stafford, {J. Lawrence} and Thomas Donner and Warren Laskey and Dana Beach and John Lopez and Andrew Davis and David Faxon and Sirimon Reutrakul and Emily Bayer and Oscar Marroquin and Howard Cohen and Mary Korytkowski and Glory Koerbel and Lisa Baxendell and Debbie Rosenfelder and Louise DeRiso and Carole Farrell and Tina Vita and Janet McGill and Ronald Krone and Richard Bach and Carol Recklein and Luepke, {Kristin M.} and Clifton, {Mary Jane} and Farkouh, {Michael E.} and Kim, {Michael C.} and Smith, {Donald A.} and Ida Guzman and Arlene Travis and James O'Keefe and Alan Forker and William Isley and Richard Moe and Paul Kennedy and Margaret Rosson and Aimee Long and Eric Bates and William Herman and Rodica Pop-Busui and Claire Duvernoy and Martin Stevens and Ann Luciano and Cheryl Majors and Gottlieb, {Sheldon H.} and Annabelle Rodriguez and Melanie Herr and David Williams and Smith, {Robert J.} and Bbott, {Dawn J.} and Laufgraben, {Marc J.} and Mary Grogan and Janice Muratori and Gabriel Habib and Marco Marcelli and Issam Mikati and Emilia Cordero and Gina Caldwell and David Chechter and Daniel Lorber and Phyllis August and Maisie Brown and Patricia Depree and Kurt Huber and Ursula Hanusch-Enserer and Nelly Jordanova and Dilek Cilesiz and Birgit Vogel and Ben McCallister and Michael Kleerekoper and Kelly Mandagere and Robert Urbanic and James Bengston and Kong, {Bobby K.} and Andrew Pruitt and Jeffrey Sanfield and Carol Carulli and Ruth Churley-Strom and Raymond Magorien and Kwame Osei and Boyer, {Cecilia Casey} and Richard Lee and Pasquale Palumbo and Joyce Wisbey and Edwin Alderman and Fumiaki Ikeno and Anne Schwarzkopf and Michael Steffes and Maren Nowicki and Jean Bucksa and Bernard Chaitman and Jane Eckstein and Karen Stocke and Hlatky, {Mark A.} and Boothroyd, {Derek B.} and Melsop, {Kathryn A.} and Sobel, {Burton E.} and Dagnija Neimane and Iskandrian, {Ami E.} and Schaaf, {Mary Beth} and Saul Genuth and Theresa Bongarno and Richard Nesto and Karen Hultberg and Helene Rosenhouse-Romeo and Georgia Pambianco and Michael Mock and Teresa, {L. Z.Jones} and Thomas Ryan and Harold Lebovitz and Robert Brown and Gottlieb Friesinger and Edward Horton and Jay Mason and Renu Virmani and Lawrence Wechsler and Bairey-Merz, {C. Noel} and {J. Ennedy}, Ward and Elliott Antman and John Colwell and Sarah Fowler and Curt Furberg and Lee Goldman and Bruce Jennings and Scott Rankin",
year = "2015",
month = "1",
day = "1",
doi = "10.1155/2015/610239",
language = "English (US)",
volume = "2015",
journal = "International Journal of Endocrinology",
issn = "1687-8337",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Sex, prescribing practices and guideline recommended, blood pressure, and LDL cholesterol targets at baseline in the BARI 2D trial

AU - Magee, Michelle F.

AU - Tamis-Holland, Jacqueline E.

AU - Lu, Jiang

AU - Bittner, Vera A.

AU - Brooks, Maria Mori

AU - Lopes, Neuza

AU - Jacobs, Alice K.

AU - Detre, Katherine M.

AU - Kelsey, Sheryl F.

AU - Orchard, Trevor J.

AU - Thomas, Stephen B.

AU - Tyrrell, Kim Sutton

AU - Rana, Jamal S.

AU - Averbach, Frani

AU - MacGregor, Joan M.

AU - O'Neal, Scott M.

AU - Pitluga, Kathleen

AU - Sansing, Veronica

AU - Tranchine, Mary

AU - Crow, Sharon W.

AU - Bertolet, Marianne

AU - Hardison, Regina

AU - Kip, Kevin

AU - Lombardero, Manuel

AU - Janiszewski, Sue

AU - Protivnak, Darina

AU - Reiser, Sarah

AU - Barton, Stephen

AU - Guo, Ping

AU - Kushner, Yulia

AU - Martin, Jeffrey P.

AU - Kania, Christopher

AU - Kania, Michael

AU - O'Donnell, Jeffrey

AU - Maxwell, Rae Ann

AU - Frye, Robert L.

AU - Goldberg, Suzanne

AU - Rosenberg, Yves

AU - Desvigne-Nickens, Patrice

AU - Ershow, Abby

AU - Gordon, David

AU - Paltoo, Dina

AU - Jones, Teresa L.Z.

AU - Hueb, Whady

AU - Ramires, José

AU - Wajchenberg, Bernardo Léo

AU - Martinez, Eulogio E.

AU - Oliveira, Sergio A.

AU - Ribeiro, Expedito E.

AU - Perin, Marcos

AU - Betti, Roberto

AU - Schwartz, Leonard

AU - Steiner, George

AU - Barolet, Alan

AU - Groenewoud, Yolanda

AU - Mighton, Lisa

AU - Camelon, Kathy

AU - O'Rourke, Robert

AU - Blodgett, Janet

AU - Sako, Edward

AU - Nicastro, Judith

AU - Prescott, Robin

AU - Rihal, Charanjit

AU - Kennedy, Frank

AU - Barsness, Gregory

AU - Basu, Amanda

AU - Clavell, Alfredo

AU - Frye, Robert

AU - Holmes, David R.

AU - Lerman, Amir

AU - Mullaney, Charles

AU - Reeder, Guy

AU - Rizza, Robert

AU - Schaff, Hartzell

AU - Smith, Steven

AU - Somers, Virend

AU - Sundt, Thoralf

AU - Ting, Henry

AU - Wright, R. Scott

AU - Helgemoe, Pam

AU - Lesmeister, Diane

AU - Rolbiecki, Deborah

AU - Lepe-Montoya, Luis

AU - Escobedo, Jorge

AU - Barraza, Rafael

AU - Baleón, Rubén

AU - Campos, Arturo

AU - García, Paula

AU - Lezama, Carlos

AU - Miramontes, Carlos

AU - Ocampo, Salvador

AU - Peñafiel, Joaquí

AU - Valdespino, Aquiles

AU - Verdín, Raúl

AU - Albarrán, Hé

AU - Ayala, Fernando

AU - Chávez, Eduardo

AU - Murillo, Hé

AU - Buitrón, Luisa Virginia

AU - Rico-Verdin, Beatriz

AU - Angulo, Fabiola

AU - Adler, Dale

AU - Arthur Halle, Austin

AU - Ismail-Beigi, Faramarz

AU - Paranjape, Suvinay

AU - Mazzurco, Stacey

AU - Ridley, Karen

AU - Ramanathan, K

AU - Solomon, Solomon

AU - Wall, Barry

AU - Weinman, Darryl

AU - Touchstone, Tammy

AU - Douglas, Lillie

AU - Bourassa, Martial

AU - Tardif, Jean Claude

AU - Chiasson, Jean Louis

AU - Andre Lavoie, Marc

AU - Rabasa-Lhoret, Rémi

AU - Langelier, Hélène

AU - Foucher, Suzy

AU - Trudel, Johanne

AU - Monrad, Scott

AU - Srinivas, Vankeepuram

AU - Zonszein, Joel

AU - Crandall, Jill

AU - Duffy, Helena

AU - Vartolomei, Eugen

AU - King, Spencer

AU - Jacobs, Carl

AU - Robertson, David

AU - Porter, Marty

AU - Eley, Melanie

AU - Nichols, Emmalee

AU - LaCorte, Jennifer

AU - Mock, Melinda

AU - Rogers, William

AU - Ovalle, Fernando

AU - Bell, David

AU - Misra, Vijay K.

AU - Hillegass, William B.

AU - Aqel, Raed

AU - Pierce, Penny

AU - Smith, Melanie

AU - Saag, Leah

AU - Vaughn, Ashley

AU - Smith, Dwight

AU - Grimes, Tiffany

AU - Rolli, Susan

AU - Hill, Roberta

AU - Dean Barrett, Beth

AU - Morehead, Clarinda

AU - Doss, Ken

AU - Davidson, Charles J.

AU - Molitch, Mark

AU - Beohar, Nirat

AU - Massaro, Elaine

AU - Goodreau, Lynne

AU - Arroyo, Fabiola

AU - Neužil, Petr

AU - Pavlíɥková, Lenka

AU - Stehlíková, Štěpánka

AU - Benedik, Jaroslav

AU - Coling, Liz

AU - Davies, Richard

AU - Glover, Christopher

AU - LeMay, Michel

AU - Mesana, Thierry

AU - Ooi, Teik Chye

AU - Silverman, Mark

AU - Sorisky, Alexander

AU - Favreau, Colette

AU - McClinton, Susan

AU - Weiss, Melvin

AU - Weiss, Irene

AU - Saulle, Leo

AU - Kannam, Harichandra

AU - Kurylas, Joanne C.

AU - Vasi, Lorraine

AU - Douglas, John

AU - Ghazzal, Ziyad

AU - Sperling, Laurence

AU - Dayamani, Priya

AU - Gebhart, Suzanne

AU - Basu, Sabreena

AU - Helmy, Tarek

AU - Tangpricha, Vin

AU - Hyde, Pamela

AU - Jenkins, Margaret

AU - Grant, Barbara P.

AU - Kent, Kenneth

AU - Suddath, William

AU - Julien-Williams, Patricia

AU - Reed, Vida

AU - Nassar, Carine

AU - Dagenais, Gilles

AU - Garceau, Claude

AU - Auger, Dominique

AU - Buller, Christopher

AU - Elliott, Tom

AU - Ramanathan, Krishnan

AU - Ricci, Donald

AU - Fox, Rebecca

AU - Kolesniak, Daniela

AU - Attubato, Michael

AU - Feit, Frederick

AU - Richardson, Stephen

AU - Sing, Ivan Pena

AU - Slater, James

AU - Amendola, Angela

AU - Vargas, Bernardo

AU - Tsapatsaris, Nicholas

AU - Woods, Bartholomew

AU - Cushing, Gary

AU - Rutter, Martin K.

AU - Singh, Premranjan

AU - DesRochers, Gail

AU - Woodhead, Gail

AU - Gannon, Deborah

AU - Campbell, Nancy Shinopulos

AU - Ragosta, Michael

AU - Sarembock, Ian

AU - Powers, Eric

AU - Barrett, Eugene

AU - Jahn, Linda

AU - Murie, Karen

AU - Das, Gladwin

AU - Sigurdsson, Gardar

AU - White, Carl

AU - Bantle, John

AU - Redmon, J. Bruce

AU - Kwong, Christine

AU - Albu, Jeanine

AU - Hochman, Judith S.

AU - Wilentz, James

AU - Frances, Sylvaine

AU - Tormey, Deborah

AU - Pepine, Carl

AU - Smith, Karen

AU - Kennedy, Laurence

AU - Brezner, Karen

AU - Curry, Tempa

AU - Bleyer, Frank

AU - Albert, Stewart

AU - Mooradian, Arshag

AU - Plummer, Sharon

AU - Fuentes, Francisco

AU - Robles, Roberto

AU - Lavis, Victor

AU - Gomez, Jaime

AU - Iliescu, Cesar

AU - Underwood, Carol

AU - Fulton, Maria Selin

AU - Ramirez, Julie Gomez

AU - Merta, Jennifer

AU - Scott, Glenna

AU - Krishnaswami, Ashok

AU - Dowdell, Lynn

AU - Berkheimer, Sarah

AU - Greenbaum, Adam

AU - Whitehouse, Fred

AU - Pangilinan, Raquel

AU - Mann, Kelly

AU - Sternthal, Elliot

AU - Ebner, Susana

AU - Nedeljkovic, Zoran

AU - Beardsley, Paula

AU - Schneider, David

AU - Pratley, Richard

AU - Cefalu, William

AU - Schnure, Joel

AU - Rowen, Michaelanne

AU - Tilton, Linda

AU - Niederman, Alan

AU - Mata, Cristina

AU - Kellerman, Terri

AU - Farmer, John

AU - Garber, Alan J.

AU - Kleiman, Neal

AU - Howard, Nancy

AU - Nichols, Debra

AU - Pool, Madonna

AU - Granger, Christopher

AU - Feinglos, Mark

AU - Adams, George

AU - Green, Jennifer

AU - Druken, Bernadette

AU - Underwood, Dani

AU - Stafford, J. Lawrence

AU - Donner, Thomas

AU - Laskey, Warren

AU - Beach, Dana

AU - Lopez, John

AU - Davis, Andrew

AU - Faxon, David

AU - Reutrakul, Sirimon

AU - Bayer, Emily

AU - Marroquin, Oscar

AU - Cohen, Howard

AU - Korytkowski, Mary

AU - Koerbel, Glory

AU - Baxendell, Lisa

AU - Rosenfelder, Debbie

AU - DeRiso, Louise

AU - Farrell, Carole

AU - Vita, Tina

AU - McGill, Janet

AU - Krone, Ronald

AU - Bach, Richard

AU - Recklein, Carol

AU - Luepke, Kristin M.

AU - Clifton, Mary Jane

AU - Farkouh, Michael E.

AU - Kim, Michael C.

AU - Smith, Donald A.

AU - Guzman, Ida

AU - Travis, Arlene

AU - O'Keefe, James

AU - Forker, Alan

AU - Isley, William

AU - Moe, Richard

AU - Kennedy, Paul

AU - Rosson, Margaret

AU - Long, Aimee

AU - Bates, Eric

AU - Herman, William

AU - Pop-Busui, Rodica

AU - Duvernoy, Claire

AU - Stevens, Martin

AU - Luciano, Ann

AU - Majors, Cheryl

AU - Gottlieb, Sheldon H.

AU - Rodriguez, Annabelle

AU - Herr, Melanie

AU - Williams, David

AU - Smith, Robert J.

AU - Bbott, Dawn J.

AU - Laufgraben, Marc J.

AU - Grogan, Mary

AU - Muratori, Janice

AU - Habib, Gabriel

AU - Marcelli, Marco

AU - Mikati, Issam

AU - Cordero, Emilia

AU - Caldwell, Gina

AU - Chechter, David

AU - Lorber, Daniel

AU - August, Phyllis

AU - Brown, Maisie

AU - Depree, Patricia

AU - Huber, Kurt

AU - Hanusch-Enserer, Ursula

AU - Jordanova, Nelly

AU - Cilesiz, Dilek

AU - Vogel, Birgit

AU - McCallister, Ben

AU - Kleerekoper, Michael

AU - Mandagere, Kelly

AU - Urbanic, Robert

AU - Bengston, James

AU - Kong, Bobby K.

AU - Pruitt, Andrew

AU - Sanfield, Jeffrey

AU - Carulli, Carol

AU - Churley-Strom, Ruth

AU - Magorien, Raymond

AU - Osei, Kwame

AU - Boyer, Cecilia Casey

AU - Lee, Richard

AU - Palumbo, Pasquale

AU - Wisbey, Joyce

AU - Alderman, Edwin

AU - Ikeno, Fumiaki

AU - Schwarzkopf, Anne

AU - Steffes, Michael

AU - Nowicki, Maren

AU - Bucksa, Jean

AU - Chaitman, Bernard

AU - Eckstein, Jane

AU - Stocke, Karen

AU - Hlatky, Mark A.

AU - Boothroyd, Derek B.

AU - Melsop, Kathryn A.

AU - Sobel, Burton E.

AU - Neimane, Dagnija

AU - Iskandrian, Ami E.

AU - Schaaf, Mary Beth

AU - Genuth, Saul

AU - Bongarno, Theresa

AU - Nesto, Richard

AU - Hultberg, Karen

AU - Rosenhouse-Romeo, Helene

AU - Pambianco, Georgia

AU - Mock, Michael

AU - Teresa, L. Z.Jones

AU - Ryan, Thomas

AU - Lebovitz, Harold

AU - Brown, Robert

AU - Friesinger, Gottlieb

AU - Horton, Edward

AU - Mason, Jay

AU - Virmani, Renu

AU - Wechsler, Lawrence

AU - Bairey-Merz, C. Noel

AU - J. Ennedy, Ward

AU - Antman, Elliott

AU - Colwell, John

AU - Fowler, Sarah

AU - Furberg, Curt

AU - Goldman, Lee

AU - Jennings, Bruce

AU - Rankin, Scott

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background. Research has shown less aggressive treatment and poorer control of cardiovascular disease (CVD) risk factors in women than men. Methods. We analyzed sex differences in pharmacotherapy strategies and attainment of goals for hemoglobin A1c (HbA1c), blood pressure (BP), and low density lipoprotein cholesterol (LDL-C) in patients with type 2 diabetes and established coronary artery disease enrolled into the BARI 2D trial. Results. Similar numbers of drugs were prescribed in both women and men. Women were less frequent on metformin or sulfonylurea and more likely to take insulin and to be on higher doses of hydroxymethylglutaryl-CoA reductase inhibitors (statins) than men. After adjusting for baseline differences and treatment prescribed, women were less likely to achieve goals for HbA1c (OR = 0.71, 95% CI 0.57, 0.88) and LDL-C (OR = 0.64, 95% CI 0.53, 0.78). More antihypertensives were prescribed to women, and yet BP ≤ 130/80 mmHg did not differ by sex. Conclusions. Women entering the BARI 2D trial were as aggressively treated with drugs as men. Despite equivalent treatment, women less frequently met targets for HbA1c and LDL-C. Our findings suggest that there may be sex differences in response to drug therapies used to treat diabetes, hypertension, and hyperlipidemia.

AB - Background. Research has shown less aggressive treatment and poorer control of cardiovascular disease (CVD) risk factors in women than men. Methods. We analyzed sex differences in pharmacotherapy strategies and attainment of goals for hemoglobin A1c (HbA1c), blood pressure (BP), and low density lipoprotein cholesterol (LDL-C) in patients with type 2 diabetes and established coronary artery disease enrolled into the BARI 2D trial. Results. Similar numbers of drugs were prescribed in both women and men. Women were less frequent on metformin or sulfonylurea and more likely to take insulin and to be on higher doses of hydroxymethylglutaryl-CoA reductase inhibitors (statins) than men. After adjusting for baseline differences and treatment prescribed, women were less likely to achieve goals for HbA1c (OR = 0.71, 95% CI 0.57, 0.88) and LDL-C (OR = 0.64, 95% CI 0.53, 0.78). More antihypertensives were prescribed to women, and yet BP ≤ 130/80 mmHg did not differ by sex. Conclusions. Women entering the BARI 2D trial were as aggressively treated with drugs as men. Despite equivalent treatment, women less frequently met targets for HbA1c and LDL-C. Our findings suggest that there may be sex differences in response to drug therapies used to treat diabetes, hypertension, and hyperlipidemia.

UR - http://www.scopus.com/inward/record.url?scp=84927601878&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84927601878&partnerID=8YFLogxK

U2 - 10.1155/2015/610239

DO - 10.1155/2015/610239

M3 - Article

VL - 2015

JO - International Journal of Endocrinology

JF - International Journal of Endocrinology

SN - 1687-8337

M1 - 610239

ER -