Sex Steroid Combinations in Regenerative Medicine for Brain and Heart Diseases: The Vascular Stem Cell Niche and a Clinical Proposal

Antonin Bukovsky, Michael Caudle

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

"Cell therapy without the cells" means the process of utilizing endogenous stem cells instead of using an exogenous cell source for treating medical conditions. We have demonstrated that combinations of sex steroids such as estradiol, testosterone, and progesterone will transdifferentiate (reprogram) ovarian epithelial cells into neural stem cells. A similar effect was observed in cultures of vascular smooth muscle cells. Combinations of progesterone and testosterone may be sufficient for brain regenerative treatment since estradiol can be produced by targeted cells. We propose that therapies employing the transdifferentiation of autologous progenitor cells in situ by drugs may provide practical approaches in treating neurological and vascular disorders. A cellular-chemical approach, such as the combination of sex steroids to stimulate endogenous stem cells for treatment of neuronal, vascular, or heart disorders is suggested. In aging individuals or patients at risk, intermittent treatment with common doses of combined sex steroids for a period of 2-4weeks may have a regenerative or preventive effect. Regenerative medicine, however, may be more successful in acute/traumatic disorders with an intact morphostatic stem cell niche as opposed to patients with chronic degenerative diseases and an altered stem cell niche. Degenerative diseases may be associated with tissue cell apoptosis. If able to alter morphostasis, we may disrupt the cellular apoptotic process and provide a new treatment for chronic degenerative diseases.

Original languageEnglish (US)
Title of host publicationCell and Molecular Biology and Imaging of Stem Cells
PublisherWiley-Blackwell
Pages193-210
Number of pages18
Volume9781118284100
ISBN (Electronic)9781118285602
ISBN (Print)9781118284100
DOIs
StatePublished - Nov 10 2014

Fingerprint

Stem Cell Niche
Regenerative Medicine
Brain Diseases
Stem cells
Blood Vessels
Heart Diseases
Brain
Steroids
Stem Cells
Progesterone
Testosterone
Estradiol
Chronic Disease
Therapeutics
Neural Stem Cells
Cell- and Tissue-Based Therapy
Nervous System Diseases
Vascular Smooth Muscle
Cell culture
Smooth Muscle Myocytes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Bukovsky, A., & Caudle, M. (2014). Sex Steroid Combinations in Regenerative Medicine for Brain and Heart Diseases: The Vascular Stem Cell Niche and a Clinical Proposal. In Cell and Molecular Biology and Imaging of Stem Cells (Vol. 9781118284100, pp. 193-210). Wiley-Blackwell. https://doi.org/10.1002/9781118285602.ch8

Sex Steroid Combinations in Regenerative Medicine for Brain and Heart Diseases : The Vascular Stem Cell Niche and a Clinical Proposal. / Bukovsky, Antonin; Caudle, Michael.

Cell and Molecular Biology and Imaging of Stem Cells. Vol. 9781118284100 Wiley-Blackwell, 2014. p. 193-210.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bukovsky, A & Caudle, M 2014, Sex Steroid Combinations in Regenerative Medicine for Brain and Heart Diseases: The Vascular Stem Cell Niche and a Clinical Proposal. in Cell and Molecular Biology and Imaging of Stem Cells. vol. 9781118284100, Wiley-Blackwell, pp. 193-210. https://doi.org/10.1002/9781118285602.ch8
Bukovsky A, Caudle M. Sex Steroid Combinations in Regenerative Medicine for Brain and Heart Diseases: The Vascular Stem Cell Niche and a Clinical Proposal. In Cell and Molecular Biology and Imaging of Stem Cells. Vol. 9781118284100. Wiley-Blackwell. 2014. p. 193-210 https://doi.org/10.1002/9781118285602.ch8
Bukovsky, Antonin ; Caudle, Michael. / Sex Steroid Combinations in Regenerative Medicine for Brain and Heart Diseases : The Vascular Stem Cell Niche and a Clinical Proposal. Cell and Molecular Biology and Imaging of Stem Cells. Vol. 9781118284100 Wiley-Blackwell, 2014. pp. 193-210
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