Shaping Diversity Into the Brain’s Form and Function

Lauren N. Miterko, Elizabeth P. Lackey, Detlef Heck, Roy V. Sillitoe

Research output: Contribution to journalReview article

Abstract

The brain contains a large diversity of unique cell types that use specific genetic programs to control development and instruct the intricate wiring of sensory, motor, and cognitive brain regions. In addition to their cellular diversity and specialized connectivity maps, each region’s dedicated function is also expressed in their characteristic gross external morphologies. The folds on the surface of the cerebral cortex and cerebellum are classic examples. But, to what extent does structure relate to function and at what spatial scale? We discuss the mechanisms that sculpt functional brain maps and external morphologies. We also contrast the cryptic structural defects in conditions such as autism spectrum disorders to the overt microcephaly after Zika infections, taking into consideration that both diseases disrupt proper cognitive development. The data indicate that dynamic processes shape all brain areas to fit into jigsaw-like patterns. The patterns in each region reflect circuit connectivity, which ultimately supports local signal processing and accomplishes multi-areal integration of information processing to optimize brain functions.

Original languageEnglish (US)
Article number83
JournalFrontiers in Neural Circuits
Volume12
DOIs
StatePublished - Oct 10 2018

Fingerprint

Brain
Microcephaly
Automatic Data Processing
Cerebral Cortex
Cerebellum
Infection
Autism Spectrum Disorder

All Science Journal Classification (ASJC) codes

  • Neuroscience (miscellaneous)
  • Sensory Systems
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Shaping Diversity Into the Brain’s Form and Function. / Miterko, Lauren N.; Lackey, Elizabeth P.; Heck, Detlef; Sillitoe, Roy V.

In: Frontiers in Neural Circuits, Vol. 12, 83, 10.10.2018.

Research output: Contribution to journalReview article

Miterko, Lauren N. ; Lackey, Elizabeth P. ; Heck, Detlef ; Sillitoe, Roy V. / Shaping Diversity Into the Brain’s Form and Function. In: Frontiers in Neural Circuits. 2018 ; Vol. 12.
@article{a719e96b32a04fdda3bb4f57d89369cf,
title = "Shaping Diversity Into the Brain’s Form and Function",
abstract = "The brain contains a large diversity of unique cell types that use specific genetic programs to control development and instruct the intricate wiring of sensory, motor, and cognitive brain regions. In addition to their cellular diversity and specialized connectivity maps, each region’s dedicated function is also expressed in their characteristic gross external morphologies. The folds on the surface of the cerebral cortex and cerebellum are classic examples. But, to what extent does structure relate to function and at what spatial scale? We discuss the mechanisms that sculpt functional brain maps and external morphologies. We also contrast the cryptic structural defects in conditions such as autism spectrum disorders to the overt microcephaly after Zika infections, taking into consideration that both diseases disrupt proper cognitive development. The data indicate that dynamic processes shape all brain areas to fit into jigsaw-like patterns. The patterns in each region reflect circuit connectivity, which ultimately supports local signal processing and accomplishes multi-areal integration of information processing to optimize brain functions.",
author = "Miterko, {Lauren N.} and Lackey, {Elizabeth P.} and Detlef Heck and Sillitoe, {Roy V.}",
year = "2018",
month = "10",
day = "10",
doi = "10.3389/fncir.2018.00083",
language = "English (US)",
volume = "12",
journal = "Frontiers in Neural Circuits",
issn = "1662-5110",
publisher = "Frontiers Research Foundation",

}

TY - JOUR

T1 - Shaping Diversity Into the Brain’s Form and Function

AU - Miterko, Lauren N.

AU - Lackey, Elizabeth P.

AU - Heck, Detlef

AU - Sillitoe, Roy V.

PY - 2018/10/10

Y1 - 2018/10/10

N2 - The brain contains a large diversity of unique cell types that use specific genetic programs to control development and instruct the intricate wiring of sensory, motor, and cognitive brain regions. In addition to their cellular diversity and specialized connectivity maps, each region’s dedicated function is also expressed in their characteristic gross external morphologies. The folds on the surface of the cerebral cortex and cerebellum are classic examples. But, to what extent does structure relate to function and at what spatial scale? We discuss the mechanisms that sculpt functional brain maps and external morphologies. We also contrast the cryptic structural defects in conditions such as autism spectrum disorders to the overt microcephaly after Zika infections, taking into consideration that both diseases disrupt proper cognitive development. The data indicate that dynamic processes shape all brain areas to fit into jigsaw-like patterns. The patterns in each region reflect circuit connectivity, which ultimately supports local signal processing and accomplishes multi-areal integration of information processing to optimize brain functions.

AB - The brain contains a large diversity of unique cell types that use specific genetic programs to control development and instruct the intricate wiring of sensory, motor, and cognitive brain regions. In addition to their cellular diversity and specialized connectivity maps, each region’s dedicated function is also expressed in their characteristic gross external morphologies. The folds on the surface of the cerebral cortex and cerebellum are classic examples. But, to what extent does structure relate to function and at what spatial scale? We discuss the mechanisms that sculpt functional brain maps and external morphologies. We also contrast the cryptic structural defects in conditions such as autism spectrum disorders to the overt microcephaly after Zika infections, taking into consideration that both diseases disrupt proper cognitive development. The data indicate that dynamic processes shape all brain areas to fit into jigsaw-like patterns. The patterns in each region reflect circuit connectivity, which ultimately supports local signal processing and accomplishes multi-areal integration of information processing to optimize brain functions.

UR - http://www.scopus.com/inward/record.url?scp=85054828087&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054828087&partnerID=8YFLogxK

U2 - 10.3389/fncir.2018.00083

DO - 10.3389/fncir.2018.00083

M3 - Review article

VL - 12

JO - Frontiers in Neural Circuits

JF - Frontiers in Neural Circuits

SN - 1662-5110

M1 - 83

ER -