Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41

Yumei Xiong, Norimasa Miyamoto, Kenji Shibata, Mark A. Valasek, Toshiyuki Motoike, Rafal Kedzierski, Masashi Yanagisawa

Research output: Contribution to journalArticle

370 Citations (Scopus)

Abstract

Leptin is an adipose-derived hormone that regulates a wide variety of physiological processes, including feeding behavior, metabolic rate, sympathetic nerve activity, reproduction, and immune response. Circulating leptin levels are tightly regulated according to energy homeostasis in vivo. Although mechanisms for the regulation of leptin production in adipocytes are not well understood, G protein-coupled receptors may play an important role in this adipocyte function. Here we report that C2-C6 short-chain fatty acids, ligands of an orphan G protein-coupled receptor GPR41, stimulate leptin expression in both a mouse adipocyte cell line and mouse adipose tissue in primary culture. Acute oral administration of propionate increases circulating leptin levels in mice. The concentrations of short-chain fatty acids required to stimulate leptin production are within physiological ranges, suggesting the relevance of this pathway in vivo.

Original languageEnglish (US)
Pages (from-to)1045-1050
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume101
Issue number4
DOIs
StatePublished - Jan 27 2004
Externally publishedYes

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Volatile Fatty Acids
G-Protein-Coupled Receptors
Leptin
Adipocytes
Physiological Phenomena
Propionates
Feeding Behavior
Reproduction
Oral Administration
Adipose Tissue
Homeostasis
Hormones
Ligands
Cell Line

All Science Journal Classification (ASJC) codes

  • General

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Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. / Xiong, Yumei; Miyamoto, Norimasa; Shibata, Kenji; Valasek, Mark A.; Motoike, Toshiyuki; Kedzierski, Rafal; Yanagisawa, Masashi.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, No. 4, 27.01.2004, p. 1045-1050.

Research output: Contribution to journalArticle

Xiong, Yumei ; Miyamoto, Norimasa ; Shibata, Kenji ; Valasek, Mark A. ; Motoike, Toshiyuki ; Kedzierski, Rafal ; Yanagisawa, Masashi. / Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. In: Proceedings of the National Academy of Sciences of the United States of America. 2004 ; Vol. 101, No. 4. pp. 1045-1050.
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