Sialoside-based pattern recognitions discriminating infections from tissue injuries

Yang Liu, Guoyun Chen, Pan Zheng

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Recognition of pathogens-associated molecular patterns (PAMPs) by Toll-like receptors (TLRs), NOD-like receptors (NLRs) and RIG-I-like receptors (RLR) plays a critical role in protecting host against pathogens. In addition, TLR and NLR also recognize danger-associated molecular patterns (DAMPs) to initiate limited innate immune responses. While innate immune response to DAMPs may be important for tissue repairs and wound healing, it is normally well controlled to avoid autoimmune destruction. Recent data support a role for sialoside-based pattern recognition by members of the Siglec family to attenuate innate immunity. In particular, since CD24-Siglec 10/G interaction selectively dampens host response to DAMPs but not PAMPs, this sialoside-based pattern recognition may serve as a foundation to discriminate PAMPs from DAMPs.

Original languageEnglish (US)
Pages (from-to)41-45
Number of pages5
JournalCurrent Opinion in Immunology
Volume23
Issue number1
DOIs
StatePublished - Feb 1 2011

Fingerprint

Sialic Acid Binding Immunoglobulin-like Lectins
Innate Immunity
Toll-Like Receptors
Wounds and Injuries
Infection
Wound Healing
Pathogen-Associated Molecular Pattern Molecules
NLR Proteins

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Sialoside-based pattern recognitions discriminating infections from tissue injuries. / Liu, Yang; Chen, Guoyun; Zheng, Pan.

In: Current Opinion in Immunology, Vol. 23, No. 1, 01.02.2011, p. 41-45.

Research output: Contribution to journalReview article

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