Significance thresholds for quantitative trait locus mapping under selective genotyping

Ani Manichaikul, Abraham A. Palmer, Saunak Sen, Karl W. Broman

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

In the case of selective genotyping, the usual permutation test to establish statistical significance for quantitative trait locus (QTL) mapping can give inappropriate significance thresholds, especially when the phenotype distribution is skewed. A stratified permutation test should be used, with phenotypes shuffled separately within the genotyped and ungenotyped individuals.

Original languageEnglish (US)
Pages (from-to)1963-1966
Number of pages4
JournalGenetics
Volume177
Issue number3
DOIs
StatePublished - Nov 1 2007

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Quantitative Trait Loci
Phenotype

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Significance thresholds for quantitative trait locus mapping under selective genotyping. / Manichaikul, Ani; Palmer, Abraham A.; Sen, Saunak; Broman, Karl W.

In: Genetics, Vol. 177, No. 3, 01.11.2007, p. 1963-1966.

Research output: Contribution to journalArticle

Manichaikul, Ani ; Palmer, Abraham A. ; Sen, Saunak ; Broman, Karl W. / Significance thresholds for quantitative trait locus mapping under selective genotyping. In: Genetics. 2007 ; Vol. 177, No. 3. pp. 1963-1966.
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