Simulation and validation of point spread functions in pinhole SPECT imaging

Tobias Funk, Dennis L. Kirch, Mingshan Sun, Enrique Izaguirre, John E. Koss, Sven Prevrhal, Bruce H. Hasegawa

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Modeling and assessment of point spread functions (PSFs) of pinhole collimators is essential for the design of small animal single photon emission computed tomography (SPECT) imaging systems, and are gaining increasing importance with the advent of multipinhole imaging techniques. PSFs also can be used in resolution recovery methods implemented in reconstruction algorithms. Therefore, we have developed and validated a ray-tracing approach to calculate PSFs and absolute detection efficiency of pinhole collimators in radionuclide imaging. The PSFs were calculated for user defined pinhole and source geometries with multiple rays to account for collimator penetration. For validation we compared our simulations to analytical models, Monte Carlo simulations from literature, and experiments with 99 m Tc sources using a variety of pinhole geometries including knife and keel edges. We find that shape and magnitude of the simulated PSFs are in very good agreement with analytical and experimental results. Importantly, our simulations show that the absolute detection efficiency of pinhole systems can be computed with an accuracy error of less than 10% using the ray-tracing approach. In contrast to Monte Carlo simulations ray-tracing simulations are computational very efficient and therefore very fast. In conclusion, we developed a ray-tracing method that calculates PSFs and detection efficiencies for different pinhole and source geometries quickly and reliably.

Original languageEnglish (US)
Article number1710262
Pages (from-to)2729-2735
Number of pages7
JournalIEEE Transactions on Nuclear Science
Volume53
Issue number5
DOIs
StatePublished - Oct 1 2006

Fingerprint

Single photon emission computed tomography
Optical transfer function
pinholes
point spread functions
tomography
Ray tracing
Imaging techniques
ray tracing
photons
collimators
simulation
Geometry
geometry
keels
Radioisotopes
imaging techniques
Imaging systems
radioactive isotopes
animals
Analytical models

All Science Journal Classification (ASJC) codes

  • Nuclear and High Energy Physics
  • Nuclear Energy and Engineering
  • Electrical and Electronic Engineering

Cite this

Funk, T., Kirch, D. L., Sun, M., Izaguirre, E., Koss, J. E., Prevrhal, S., & Hasegawa, B. H. (2006). Simulation and validation of point spread functions in pinhole SPECT imaging. IEEE Transactions on Nuclear Science, 53(5), 2729-2735. [1710262]. https://doi.org/10.1109/TNS.2006.878009

Simulation and validation of point spread functions in pinhole SPECT imaging. / Funk, Tobias; Kirch, Dennis L.; Sun, Mingshan; Izaguirre, Enrique; Koss, John E.; Prevrhal, Sven; Hasegawa, Bruce H.

In: IEEE Transactions on Nuclear Science, Vol. 53, No. 5, 1710262, 01.10.2006, p. 2729-2735.

Research output: Contribution to journalArticle

Funk, T, Kirch, DL, Sun, M, Izaguirre, E, Koss, JE, Prevrhal, S & Hasegawa, BH 2006, 'Simulation and validation of point spread functions in pinhole SPECT imaging', IEEE Transactions on Nuclear Science, vol. 53, no. 5, 1710262, pp. 2729-2735. https://doi.org/10.1109/TNS.2006.878009
Funk, Tobias ; Kirch, Dennis L. ; Sun, Mingshan ; Izaguirre, Enrique ; Koss, John E. ; Prevrhal, Sven ; Hasegawa, Bruce H. / Simulation and validation of point spread functions in pinhole SPECT imaging. In: IEEE Transactions on Nuclear Science. 2006 ; Vol. 53, No. 5. pp. 2729-2735.
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