Single-dose oral ciprofloxacin compared with cefotaxime and placebo for prophylaxis during transurethral surgery

Ira W. Klimberg, G. H. Malek, Clair E. Cox, Anthony Patterson, Edward Whalen, Steven F. Kowalsky, Roger M. Echols

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

To determine the efficacy and safety of single-dose oral ciprofloxacin prophylaxis for the prevention of post-operative bacteriuria following transurethral resection of the prostate or bladder tumour, a prospective, randomized, double-blind, placebo-controlled trial was conducted. Five hundred and eighteen patients were randomized in a 2:2:1 ratio to receive ciprofloxacin 500 mg, cefotaxime 1 g or placebo 30-90 min before surgery. Of the 368 efficacy-evaluable patients, five (3.3%) ciprofloxacin, seven (4.8%) cefotaxime and five (7.0%) placebo recipients had postoperative bacteriuria (≥ 104 cfu/mL) during post-operative days 2-15. Five (3.4%) ciprofloxacin, five (3.4%) cefotaxime and one (2.4%) placebo recipients were considered clinical failures, of whom one, two and one patients, respectively, had concomitant bacteriuria. Drug-related adverse events were reported in six of 204 (3%) ciprofloxacin, 12 of 197 (6%) cefotaxime and one of 101 (1%) placebo patients. The observed rates of post-operative bacteriuria suggest that a single 500 mg dose of ciprofloxacin is suitable prophylaxis for transurethral surgery.

Original languageEnglish (US)
Pages (from-to)77-84
Number of pages8
JournalJournal of Antimicrobial Chemotherapy
Volume43
Issue numberSUPPL. A
StatePublished - Mar 22 1999

Fingerprint

Cefotaxime
Ciprofloxacin
Bacteriuria
Placebos
Transurethral Resection of Prostate
Drug-Related Side Effects and Adverse Reactions
Urinary Bladder Neoplasms
Safety

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Klimberg, I. W., Malek, G. H., Cox, C. E., Patterson, A., Whalen, E., Kowalsky, S. F., & Echols, R. M. (1999). Single-dose oral ciprofloxacin compared with cefotaxime and placebo for prophylaxis during transurethral surgery. Journal of Antimicrobial Chemotherapy, 43(SUPPL. A), 77-84.

Single-dose oral ciprofloxacin compared with cefotaxime and placebo for prophylaxis during transurethral surgery. / Klimberg, Ira W.; Malek, G. H.; Cox, Clair E.; Patterson, Anthony; Whalen, Edward; Kowalsky, Steven F.; Echols, Roger M.

In: Journal of Antimicrobial Chemotherapy, Vol. 43, No. SUPPL. A, 22.03.1999, p. 77-84.

Research output: Contribution to journalArticle

Klimberg, IW, Malek, GH, Cox, CE, Patterson, A, Whalen, E, Kowalsky, SF & Echols, RM 1999, 'Single-dose oral ciprofloxacin compared with cefotaxime and placebo for prophylaxis during transurethral surgery', Journal of Antimicrobial Chemotherapy, vol. 43, no. SUPPL. A, pp. 77-84.
Klimberg, Ira W. ; Malek, G. H. ; Cox, Clair E. ; Patterson, Anthony ; Whalen, Edward ; Kowalsky, Steven F. ; Echols, Roger M. / Single-dose oral ciprofloxacin compared with cefotaxime and placebo for prophylaxis during transurethral surgery. In: Journal of Antimicrobial Chemotherapy. 1999 ; Vol. 43, No. SUPPL. A. pp. 77-84.
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