Single nocturnal doses of pirenzepine effectively inhibit overnight gastric secretion

Colin Howden, D. W. Burget, C. Silletti, R. H. Hunt

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The gastric antisecretory effects of two dose levels of pirenzepine given at night were investigated in a group of healthy male volunteers. Compared with placebo, three days of treatment with pirenzepine 100 mg nocte or 150 mg nocte inhibited mean nocturnal intragastric acidity by 54% and 53%, respectively (p < 0.01). The volume of gastric juice secreted was reduced by 47% and 52% (p < 0.005), by 100 mg and 150 mg nocte, respectively. Each dose suppressed mean gastric acid output by 67% (p < 0.001). Pepsin output was not significantly altered. There were no differences in effect between the two dose levels studied, but side-effects such as dry mouth were only seen with the higher dose. Pirenzepine 100 mg is the optimum dose which can conveniently be given at night. This will limit side-effects, and may be a useful treatment for patients with duodenal ulcer.

Original languageEnglish (US)
Pages (from-to)240-242
Number of pages3
JournalHepato-Gastroenterology
Volume32
Issue number5
StatePublished - 1985
Externally publishedYes

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Pirenzepine
Stomach
Gastric Juice
Pepsin A
Gastric Acid
Duodenal Ulcer
Mouth
Healthy Volunteers
Placebos
Therapeutics

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Single nocturnal doses of pirenzepine effectively inhibit overnight gastric secretion. / Howden, Colin; Burget, D. W.; Silletti, C.; Hunt, R. H.

In: Hepato-Gastroenterology, Vol. 32, No. 5, 1985, p. 240-242.

Research output: Contribution to journalArticle

Howden, Colin ; Burget, D. W. ; Silletti, C. ; Hunt, R. H. / Single nocturnal doses of pirenzepine effectively inhibit overnight gastric secretion. In: Hepato-Gastroenterology. 1985 ; Vol. 32, No. 5. pp. 240-242.
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