Site-specific enhancement and suppression of desynchronized sleep signs following cholinergic stimulation of three brainstem regions

Helen Baghdoyan, Margarita L. Rodrigo-Angulo, Robert W. McCarley, J. Allan Hobson

Research output: Contribution to journalArticle

199 Citations (Scopus)

Abstract

The behavioral effects of carbachol microinjection into the pontine, midrain and medullary reticular formation (RF) have been studied. Enhancement of electrographic desynchronized (D) sleep signs and D sleep-like behavior was specific to the pons; these paramaters were contrastingly suppressed following cholinergic stimulation of the midbrain and medullary RF. Polygraphically defined wakefulness (W) was increased from the midbrain and medulla and was characterized by stereotyped motor activity, whereas slow wave (S) sleep was reduced or eliminated when carbachol was administered into all 3 brainstem regions. In addition, as a function of the site of carbachol administation within the pons, some qualitative electrographic differences betwen carbachol-induced D sleep and the physiological D sleep state were observed. These results are consistent with the hypotheses that the pontine RF is involved in the cholinergic initiation and/or maintenance of D sleep and that the midbrain RF mediates arousal via cholinoceptive reticular cells. The hypothesis that the medullary RF plays a major role in the generation of S sleep and the atonia of D sleep is not supported by these data, but non-cholinergic mechanisms of these proposed roles remain to be investigated. Preliminary reports of these data have been published3,4.

Original languageEnglish (US)
Pages (from-to)39-52
Number of pages14
JournalBrain Research
Volume306
Issue number1-2
DOIs
StatePublished - Jul 23 1984
Externally publishedYes

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Cholinergic Agents
Brain Stem
Sleep
Carbachol
Reticular Formation
Pons
Wakefulness
Microinjections
Mesencephalon
Arousal
Motor Activity
Maintenance

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Developmental Biology
  • Clinical Neurology

Cite this

Site-specific enhancement and suppression of desynchronized sleep signs following cholinergic stimulation of three brainstem regions. / Baghdoyan, Helen; Rodrigo-Angulo, Margarita L.; McCarley, Robert W.; Hobson, J. Allan.

In: Brain Research, Vol. 306, No. 1-2, 23.07.1984, p. 39-52.

Research output: Contribution to journalArticle

Baghdoyan, Helen ; Rodrigo-Angulo, Margarita L. ; McCarley, Robert W. ; Hobson, J. Allan. / Site-specific enhancement and suppression of desynchronized sleep signs following cholinergic stimulation of three brainstem regions. In: Brain Research. 1984 ; Vol. 306, No. 1-2. pp. 39-52.
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