Skeletal muscle function and hypertrophy are diminished in old age

Hans Degens, Stephen Alway

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Muscle loss occurs during aging. To investigate whether the hypertrophic response is attenuated at old age, we used male Fischer 344 (26 months old; n = 5) and Fischer 344 x Brown Norway rats (6, 9, and 33 months old; n = 8, 10, and 6, respectively). Hypertrophy of the left plantaris muscle was induced by surgical denervation of its agonists. The right leg served as control. The mass and maximal tetanic force (Po) of control muscles declined by ∼30% between 9 and 26 months (P < 0.05). Fatigue resistance during intermittent isometric contractions was reduced by ∼60% at 33 months. At 33 months, the attenuated hypertrophy was accompanied by a decrease rather than an increase in Po. Yet, hypertrophy was accompanied by a 25% rise in fatigue resistance at all ages (P = 0.001). Thus, aging is associated with a decline in muscle mass and function. In addition, at advanced age, the hypertrophic response is reduced and a hypertrophic stimulus even aggravates the age-associated muscle weakening.

Original languageEnglish (US)
Pages (from-to)339-347
Number of pages9
JournalMuscle and Nerve
Volume27
Issue number3
DOIs
StatePublished - Mar 1 2003
Externally publishedYes

Fingerprint

Hypertrophy
Skeletal Muscle
Muscles
Fatigue
Isometric Contraction
Denervation
Leg

All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

Cite this

Skeletal muscle function and hypertrophy are diminished in old age. / Degens, Hans; Alway, Stephen.

In: Muscle and Nerve, Vol. 27, No. 3, 01.03.2003, p. 339-347.

Research output: Contribution to journalArticle

@article{e0b08b8c05b1429ea9258787e43c935d,
title = "Skeletal muscle function and hypertrophy are diminished in old age",
abstract = "Muscle loss occurs during aging. To investigate whether the hypertrophic response is attenuated at old age, we used male Fischer 344 (26 months old; n = 5) and Fischer 344 x Brown Norway rats (6, 9, and 33 months old; n = 8, 10, and 6, respectively). Hypertrophy of the left plantaris muscle was induced by surgical denervation of its agonists. The right leg served as control. The mass and maximal tetanic force (Po) of control muscles declined by ∼30{\%} between 9 and 26 months (P < 0.05). Fatigue resistance during intermittent isometric contractions was reduced by ∼60{\%} at 33 months. At 33 months, the attenuated hypertrophy was accompanied by a decrease rather than an increase in Po. Yet, hypertrophy was accompanied by a 25{\%} rise in fatigue resistance at all ages (P = 0.001). Thus, aging is associated with a decline in muscle mass and function. In addition, at advanced age, the hypertrophic response is reduced and a hypertrophic stimulus even aggravates the age-associated muscle weakening.",
author = "Hans Degens and Stephen Alway",
year = "2003",
month = "3",
day = "1",
doi = "10.1002/mus.10314",
language = "English (US)",
volume = "27",
pages = "339--347",
journal = "Muscle and Nerve",
issn = "0148-639X",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

TY - JOUR

T1 - Skeletal muscle function and hypertrophy are diminished in old age

AU - Degens, Hans

AU - Alway, Stephen

PY - 2003/3/1

Y1 - 2003/3/1

N2 - Muscle loss occurs during aging. To investigate whether the hypertrophic response is attenuated at old age, we used male Fischer 344 (26 months old; n = 5) and Fischer 344 x Brown Norway rats (6, 9, and 33 months old; n = 8, 10, and 6, respectively). Hypertrophy of the left plantaris muscle was induced by surgical denervation of its agonists. The right leg served as control. The mass and maximal tetanic force (Po) of control muscles declined by ∼30% between 9 and 26 months (P < 0.05). Fatigue resistance during intermittent isometric contractions was reduced by ∼60% at 33 months. At 33 months, the attenuated hypertrophy was accompanied by a decrease rather than an increase in Po. Yet, hypertrophy was accompanied by a 25% rise in fatigue resistance at all ages (P = 0.001). Thus, aging is associated with a decline in muscle mass and function. In addition, at advanced age, the hypertrophic response is reduced and a hypertrophic stimulus even aggravates the age-associated muscle weakening.

AB - Muscle loss occurs during aging. To investigate whether the hypertrophic response is attenuated at old age, we used male Fischer 344 (26 months old; n = 5) and Fischer 344 x Brown Norway rats (6, 9, and 33 months old; n = 8, 10, and 6, respectively). Hypertrophy of the left plantaris muscle was induced by surgical denervation of its agonists. The right leg served as control. The mass and maximal tetanic force (Po) of control muscles declined by ∼30% between 9 and 26 months (P < 0.05). Fatigue resistance during intermittent isometric contractions was reduced by ∼60% at 33 months. At 33 months, the attenuated hypertrophy was accompanied by a decrease rather than an increase in Po. Yet, hypertrophy was accompanied by a 25% rise in fatigue resistance at all ages (P = 0.001). Thus, aging is associated with a decline in muscle mass and function. In addition, at advanced age, the hypertrophic response is reduced and a hypertrophic stimulus even aggravates the age-associated muscle weakening.

UR - http://www.scopus.com/inward/record.url?scp=0037373085&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037373085&partnerID=8YFLogxK

U2 - 10.1002/mus.10314

DO - 10.1002/mus.10314

M3 - Article

VL - 27

SP - 339

EP - 347

JO - Muscle and Nerve

JF - Muscle and Nerve

SN - 0148-639X

IS - 3

ER -