Skin barrier structure and function and their relationship to pruritus in end-stage renal disease

Gil Yosipovitch, Maria I. Duque, Tejesh Patel, Yozo Ishiuji, Daniela A. Guzman-Sanchez, Aerlyn G. Dawn, Barry I. Freedman, Yiong H. Chan, Debra Crumrine, Peter M. Elias

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background. The relationship between dry skin and uraemic pruritus remains controversial. In addition, there is a lack of published data describing the structure and function of the stratum corneum (SC) in end-stage renal disease (ESRD). The purpose of the present study was to assess the function and structure of the skin barrier in patients with ESRD and to correlate any abnormalities with uraemic pruritus. Methods. Thirty-eight subjects participated in the study; 20 with ESRD and 18 healthy controls. Subjects underwent evaluation of SC integrity and permeability barrier recovery, SC surface pH, pruritus and dry skin. The content of glycerol, an important endogenous humectant, was assessed in D-squame tape strips from seven patients with ESRD. Skin biopsies from six of these patients were examined by electron microscopy using ruthenium tetroxide (Ru04)-post-fixation. Results. Although SC integrity was impaired in ESRD patients (P = 0.001), there were no significant differences in permeability barrier recovery rates between ESRD subjects and controls. However, there was a high significant negative correlation between SC glycerol content and dry skin in the arms of ESRD subjects (r = -0.866, P = 0.01). Yet, there was no consistent correlation between pruritus and either dry skin, SC integrity, glycerol content or surface pH. Electron microscopy revealed no significant ultra-structural abnormalities, with particular reference to the lipid bi-layer. Conclusions. SC integrity, but not permeability barrier recovery, is impaired in dialysis patients. Although dry skin in ESRD is associated with reduced SC glycerol levels, the ultra-structure appears to be unaffected.

Original languageEnglish (US)
Pages (from-to)3268-3272
Number of pages5
JournalNephrology Dialysis Transplantation
Volume22
Issue number11
DOIs
StatePublished - Nov 1 2007
Externally publishedYes

Fingerprint

Pruritus
Cornea
Chronic Kidney Failure
Skin
Glycerol
Permeability
Electron Microscopy
Hygroscopic Agents
Dialysis
Arm
Lipids
Biopsy

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Transplantation

Cite this

Yosipovitch, G., Duque, M. I., Patel, T., Ishiuji, Y., Guzman-Sanchez, D. A., Dawn, A. G., ... Elias, P. M. (2007). Skin barrier structure and function and their relationship to pruritus in end-stage renal disease. Nephrology Dialysis Transplantation, 22(11), 3268-3272. https://doi.org/10.1093/ndt/gfm375

Skin barrier structure and function and their relationship to pruritus in end-stage renal disease. / Yosipovitch, Gil; Duque, Maria I.; Patel, Tejesh; Ishiuji, Yozo; Guzman-Sanchez, Daniela A.; Dawn, Aerlyn G.; Freedman, Barry I.; Chan, Yiong H.; Crumrine, Debra; Elias, Peter M.

In: Nephrology Dialysis Transplantation, Vol. 22, No. 11, 01.11.2007, p. 3268-3272.

Research output: Contribution to journalArticle

Yosipovitch, G, Duque, MI, Patel, T, Ishiuji, Y, Guzman-Sanchez, DA, Dawn, AG, Freedman, BI, Chan, YH, Crumrine, D & Elias, PM 2007, 'Skin barrier structure and function and their relationship to pruritus in end-stage renal disease', Nephrology Dialysis Transplantation, vol. 22, no. 11, pp. 3268-3272. https://doi.org/10.1093/ndt/gfm375
Yosipovitch, Gil ; Duque, Maria I. ; Patel, Tejesh ; Ishiuji, Yozo ; Guzman-Sanchez, Daniela A. ; Dawn, Aerlyn G. ; Freedman, Barry I. ; Chan, Yiong H. ; Crumrine, Debra ; Elias, Peter M. / Skin barrier structure and function and their relationship to pruritus in end-stage renal disease. In: Nephrology Dialysis Transplantation. 2007 ; Vol. 22, No. 11. pp. 3268-3272.
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abstract = "Background. The relationship between dry skin and uraemic pruritus remains controversial. In addition, there is a lack of published data describing the structure and function of the stratum corneum (SC) in end-stage renal disease (ESRD). The purpose of the present study was to assess the function and structure of the skin barrier in patients with ESRD and to correlate any abnormalities with uraemic pruritus. Methods. Thirty-eight subjects participated in the study; 20 with ESRD and 18 healthy controls. Subjects underwent evaluation of SC integrity and permeability barrier recovery, SC surface pH, pruritus and dry skin. The content of glycerol, an important endogenous humectant, was assessed in D-squame tape strips from seven patients with ESRD. Skin biopsies from six of these patients were examined by electron microscopy using ruthenium tetroxide (Ru04)-post-fixation. Results. Although SC integrity was impaired in ESRD patients (P = 0.001), there were no significant differences in permeability barrier recovery rates between ESRD subjects and controls. However, there was a high significant negative correlation between SC glycerol content and dry skin in the arms of ESRD subjects (r = -0.866, P = 0.01). Yet, there was no consistent correlation between pruritus and either dry skin, SC integrity, glycerol content or surface pH. Electron microscopy revealed no significant ultra-structural abnormalities, with particular reference to the lipid bi-layer. Conclusions. SC integrity, but not permeability barrier recovery, is impaired in dialysis patients. Although dry skin in ESRD is associated with reduced SC glycerol levels, the ultra-structure appears to be unaffected.",
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AU - Duque, Maria I.

AU - Patel, Tejesh

AU - Ishiuji, Yozo

AU - Guzman-Sanchez, Daniela A.

AU - Dawn, Aerlyn G.

AU - Freedman, Barry I.

AU - Chan, Yiong H.

AU - Crumrine, Debra

AU - Elias, Peter M.

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N2 - Background. The relationship between dry skin and uraemic pruritus remains controversial. In addition, there is a lack of published data describing the structure and function of the stratum corneum (SC) in end-stage renal disease (ESRD). The purpose of the present study was to assess the function and structure of the skin barrier in patients with ESRD and to correlate any abnormalities with uraemic pruritus. Methods. Thirty-eight subjects participated in the study; 20 with ESRD and 18 healthy controls. Subjects underwent evaluation of SC integrity and permeability barrier recovery, SC surface pH, pruritus and dry skin. The content of glycerol, an important endogenous humectant, was assessed in D-squame tape strips from seven patients with ESRD. Skin biopsies from six of these patients were examined by electron microscopy using ruthenium tetroxide (Ru04)-post-fixation. Results. Although SC integrity was impaired in ESRD patients (P = 0.001), there were no significant differences in permeability barrier recovery rates between ESRD subjects and controls. However, there was a high significant negative correlation between SC glycerol content and dry skin in the arms of ESRD subjects (r = -0.866, P = 0.01). Yet, there was no consistent correlation between pruritus and either dry skin, SC integrity, glycerol content or surface pH. Electron microscopy revealed no significant ultra-structural abnormalities, with particular reference to the lipid bi-layer. Conclusions. SC integrity, but not permeability barrier recovery, is impaired in dialysis patients. Although dry skin in ESRD is associated with reduced SC glycerol levels, the ultra-structure appears to be unaffected.

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