Sleep-disordered breathing and arterial blood flow steal represent linked therapeutic targets in cerebral ischaemia

Kristian Barlinn, Andrei Alexandrov

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The pathogenic link between sleep-disordered breathing and early neurological deterioration in acute ischaemic stroke patients is now a subject of clinical investigations. Vasomotor reactivity and intracranial blood flow steal in response to changing vasodilatory stimuli like carbon dioxide play a pivotal role in clinical deterioration with reversed Robin Hood syndrome. A mechanical ventilatory correction in selected acute stroke patients might have a beneficial effect on sleep-disordered breathing and brain perfusion. This is a novel therapeutic target and the missing link in the pathogenesis of early neurological deterioration and stroke recurrence.

Original languageEnglish (US)
Pages (from-to)40-41
Number of pages2
JournalInternational Journal of Stroke
Volume6
Issue number1
DOIs
StatePublished - Feb 1 2011

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Sleep Apnea Syndromes
Brain Ischemia
Stroke
Songbirds
Carbon Dioxide
Therapeutics
Perfusion
Recurrence
Brain

All Science Journal Classification (ASJC) codes

  • Neurology

Cite this

Sleep-disordered breathing and arterial blood flow steal represent linked therapeutic targets in cerebral ischaemia. / Barlinn, Kristian; Alexandrov, Andrei.

In: International Journal of Stroke, Vol. 6, No. 1, 01.02.2011, p. 40-41.

Research output: Contribution to journalArticle

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