Sleep disorders in neuromuscular diseases

Upinder K. Dhand, Rajiv Dhand

Research output: Contribution to journalReview article

35 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: Patients with neuromuscular disorders (NMD) are especially vulnerable to sleep-related dysfunction. Sleep-disordered breathing often precedes diurnal respiratory failure in NMD patients, requiring timely recognition and management with noninvasive ventilation (NIV). This paper reviews the mechanisms, diagnostic evaluation, and management of sleep disorders in various neuromuscular diseases. RECENT FINDINGS: The severity, duration, and type of NMD influence the pattern of sleep disturbance. Several investigators have addressed other clinical aspects including rating scales for sleep complaints, hypocretin-1 deficiency, excessive daytime somnolence, and relation of sleep disorder with length of CTG trinucleotide repeats in myotonic dystrophy. Benefits of NIV on quality of life and survival in adults and children with chronic NMD are well established, and recently have been documented even in patients with nocturnal hypoventilation and daytime normocapnia. In contrast, the timing for investigation with polysomnography and for initiation of NIV is debated. SUMMARY: Patients with chronic NMD should be routinely assessed for sleep-disordered breathing and sleep complaints, because these are treatable complications in an otherwise progressive disease process. Further research is needed to establish the indications for polysomnography and to determine the optimal timing for initiating NIV to treat sleep-disordered breathing in patients with neuromuscular diseases.

Original languageEnglish (US)
Pages (from-to)402-408
Number of pages7
JournalCurrent Opinion in Pulmonary Medicine
Volume12
Issue number6
DOIs
StatePublished - Nov 1 2006
Externally publishedYes

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Neuromuscular Diseases
Noninvasive Ventilation
Sleep Apnea Syndromes
Sleep
Polysomnography
Trinucleotide Repeats
Hypoventilation
Myotonic Dystrophy
Respiratory Insufficiency
Quality of Life
Research Personnel
Sleep Wake Disorders
Survival
Research

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cite this

Sleep disorders in neuromuscular diseases. / Dhand, Upinder K.; Dhand, Rajiv.

In: Current Opinion in Pulmonary Medicine, Vol. 12, No. 6, 01.11.2006, p. 402-408.

Research output: Contribution to journalReview article

Dhand, Upinder K. ; Dhand, Rajiv. / Sleep disorders in neuromuscular diseases. In: Current Opinion in Pulmonary Medicine. 2006 ; Vol. 12, No. 6. pp. 402-408.
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